WormBase Tree Display for Gene: WBGene00008546

WBGene00008546 SMap: S_parent: Sequence: F07A11
  Identity: Version: 2
    Name: CGC_name: gfat-1 Paper_evidence: WBPaper00045007
          Person_evidence: WBPerson759
      Sequence_name: F07A11.2
      Molecular_name: F07A11.2a
        F07A11.2a.1
        CE03144
        F07A11.2b
        CE27915
        F07A11.2a.2
        F07A11.2b.1
      Other_name: CELE_F07A11.2 Accession_evidence: NDB BX284602
      Public_name: gfat-1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:49 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 28 Apr 2014 09:19:20 WBPerson2970 Name_change: CGC_name: gfat-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: gfat
    Allele (46)
    Strain: WBStrain00003539
    RNASeq_FPKM (74)
    GO_annotation (16)
    Contained_in_operon: CEOP2718
    Ortholog (45)
    Paralog: WBGene00009035 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
    Structured_description: Concise_description: gfat-1 encodes two isoforms of glucosamine--fructose-6-phosphate aminotransferase (EC:2.6.1.16, also known as glutamine-fructose-6-phosphate transaminase), paralogous to GFAT-2; GFAT-1 is predicted to catalyze the first, and rate-limiting, step of the hexosamine pathway in which glucosamine-6-phosphate is synthesized from L-glutamine and fructose-6-phosphate and ultimately converted to UDP-N-acetylglucosamine (UDP-GlcNAc); gfat-1 gain-of-function mutations result in resistance to endoplasmic reticulum stress and increased longevity as a result of increased UDP-Hex-NAc levels accompanied by increased activity of protein quality control mechanisms such as ER-associated protein degradation (ERAD), proteasomal activity, and autophagy; gfat-1 is expressed in many larval and adult tissues, most prominently in epidermal seam cells and the pharynx, and gfat-1 transcripts are somewhat enriched during oogenesis; gfat-1(RNAi) animals have an osmotically-sensitive embryonic lethal phenotype, presumably because of defects in chitin and eggshell synthesis. Paper_evidence: WBPaper00006390
            WBPaper00006525
            WBPaper00025054
            WBPaper00028588
            WBPaper00045007
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 09 May 2014 00:00:00
      Automated_description: Predicted to enable glutamine-fructose-6-phosphate transaminase (isomerizing) activity. Involved in IRE1-mediated unfolded protein response. Expressed in tail. Used to study Machado-Joseph disease. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 12; obesity; and type 2 diabetes mellitus. Is an ortholog of human GFPT1 (glutamine--fructose-6-phosphate transaminase 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:1440 Homo sapiens Paper_evidence: WBPaper00059351
          Curator_confirmed: WBPerson324
          Date_last_updated: 03 Jun 2021 00:00:00
    Potential_model: DOID:0110660 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4241)
      DOID:9970 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4241)
      DOID:9352 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4241,HGNC:4242)
  Models_disease_asserted: WBDOannot00000921
  Molecular_info: Corresponding_CDS: F07A11.2a
      F07A11.2b
    Corresponding_transcript: F07A11.2a.1
      F07A11.2a.2
      F07A11.2b.1
    Other_sequence (92)
    Associated_feature (13)
  Experimental_info: RNAi_result: WBRNAi00025011 Inferred_automatically: RNAi_primary
      WBRNAi00085584 Inferred_automatically: RNAi_primary
      WBRNAi00008604 Inferred_automatically: RNAi_primary
      WBRNAi00094861 Inferred_automatically: RNAi_primary
      WBRNAi00043841 Inferred_automatically: RNAi_primary
      WBRNAi00030589 Inferred_automatically: RNAi_primary
      WBRNAi00022653 Inferred_automatically: RNAi_primary
      WBRNAi00008075 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram1061
      Expr5667
      Expr11670
      Expr1019553
      Expr1033724
      Expr1147818
      Expr2012025
      Expr2030261
    Drives_construct: WBCnstr00003993
      WBCnstr00019261
      WBCnstr00032882
    Construct_product: WBCnstr00019261
      WBCnstr00032882
    Microarray_results (32)
    Expression_cluster (208)
    Interaction: WBInteraction000036719
      WBInteraction000037912
      WBInteraction000039631
      WBInteraction000040226
      WBInteraction000040297
      WBInteraction000040707
      WBInteraction000042242
      WBInteraction000042272
      WBInteraction000042273
      WBInteraction000043515
      WBInteraction000044554
      WBInteraction000044876
      WBInteraction000044929
      WBInteraction000045239
      WBInteraction000045333
      WBInteraction000045383
      WBInteraction000045833
      WBInteraction000045866
      WBInteraction000045985
      WBInteraction000046568
      WBInteraction000047255
      WBInteraction000047385
      WBInteraction000047386
      WBInteraction000047502
      WBInteraction000047888
      WBInteraction000047926
      WBInteraction000047961
      WBInteraction000048127
      WBInteraction000048439
      WBInteraction000048476
      WBInteraction000048700
      WBInteraction000048904
      WBInteraction000048905
      WBInteraction000049298
      WBInteraction000112894
      WBInteraction000147586
      WBInteraction000160835
      WBInteraction000163480
      WBInteraction000173655
      WBInteraction000191580
      WBInteraction000193130
      WBInteraction000194566
      WBInteraction000196340
      WBInteraction000198785
      WBInteraction000217078
      WBInteraction000221113
      WBInteraction000225228
      WBInteraction000226933
      WBInteraction000256228
      WBInteraction000257624
      WBInteraction000271417
      WBInteraction000274572
      WBInteraction000278623
      WBInteraction000279384
      WBInteraction000283710
      WBInteraction000288897
      WBInteraction000288898
      WBInteraction000288899
      WBInteraction000288900
      WBInteraction000288901
      WBInteraction000288902
      WBInteraction000288903
      WBInteraction000288904
      WBInteraction000288905
      WBInteraction000288906
      WBInteraction000288907
      WBInteraction000288908
      WBInteraction000288909
      WBInteraction000288910
      WBInteraction000288911
      WBInteraction000288912
      WBInteraction000288913
      WBInteraction000288914
      WBInteraction000288915
      WBInteraction000288916
      WBInteraction000288917
      WBInteraction000289927
      WBInteraction000297045
      WBInteraction000336763
      WBInteraction000344102
      WBInteraction000345459
      WBInteraction000352303
      WBInteraction000356684
      WBInteraction000360312
      WBInteraction000370134
      WBInteraction000378194
      WBInteraction000395216
      WBInteraction000401043
      WBInteraction000404736
      WBInteraction000407811
      WBInteraction000415680
      WBInteraction000419877
      WBInteraction000424282
      WBInteraction000429360
      WBInteraction000430338
      WBInteraction000444135
      WBInteraction000444925
      WBInteraction000445007
      WBInteraction000445191
      WBInteraction000447181
      WBInteraction000452625
      WBInteraction000455665
      WBInteraction000462995
      WBInteraction000463608
      WBInteraction000464120
      WBInteraction000465986
      WBInteraction000467560
      WBInteraction000469341
      WBInteraction000469402
      WBInteraction000469403
      WBInteraction000471289
      WBInteraction000472673
      WBInteraction000473448
      WBInteraction000473449
      WBInteraction000473450
      WBInteraction000473451
      WBInteraction000473629
      WBInteraction000473630
      WBInteraction000473919
      WBInteraction000474506
      WBInteraction000474842
      WBInteraction000504288
      WBInteraction000521060
      WBInteraction000521346
      WBInteraction000522944
      WBInteraction000522952
      WBInteraction000523299
      WBInteraction000523459
      WBInteraction000539264
      WBInteraction000544012
      WBInteraction000544501
      WBInteraction000548216
      WBInteraction000556629
      WBInteraction000556693
      WBInteraction000559176
      WBInteraction000563896
      WBInteraction000564854
      WBInteraction000566013
      WBInteraction000567210
      WBInteraction000567450
      WBInteraction000568558
      WBInteraction000571986
      WBInteraction000574052
      WBInteraction000574683
      WBInteraction000576085
      WBInteraction000582574
      WBInteraction000583203
      WBInteraction000585861
  Map_info: Map: II Position: 3.78428
    Positive: Positive_clone: F07A11 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (11)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene