WormBase Tree Display for Gene: WBGene00008239
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WBGene00008239 | SMap | S_parent | Sequence | C50H2 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||||
Name | CGC_name | fshr-1 | Paper_evidence | WBPaper00026667 | |||||
Person_evidence | WBPerson1139 | ||||||||
Sequence_name | C50H2.1 | ||||||||
Molecular_name | C50H2.1a | ||||||||
C50H2.1a.1 | |||||||||
CE28214 | |||||||||
C50H2.1b | |||||||||
CE48138 | |||||||||
C50H2.1b.1 | |||||||||
Other_name | lgr | Accession_evidence | EMBL | AF224743 | |||||
CELE_C50H2.1 | Accession_evidence | NDB | BX284605 | ||||||
Public_name | fshr-1 | ||||||||
DB_info | Database | AceView | gene | 5K373 | |||||
WormQTL | gene | WBGene00008239 | |||||||
WormFlux | gene | WBGene00008239 | |||||||
NDB | locus_tag | CELE_C50H2.1 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00008239|UniProtKB=L8EC40 | |||||||
family | PTHR24372 | ||||||||
NCBI | gene | 179381 | |||||||
RefSeq | protein | NM_073147.7 | |||||||
NM_001276924.3 | |||||||||
TrEMBL | UniProtAcc | L8EC40 | |||||||
G5EG04 | |||||||||
UniProt_GCRP | UniProtAcc | L8EC40 | |||||||
OMIM | gene | 136435 | |||||||
152790 | |||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 26 May 2004 16:54:48 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
2 | 12 Sep 2005 16:03:13 | WBPerson2970 | Name_change | CGC_name | fshr-1 | ||||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | fshr | ||||||||
Allele (65) | |||||||||
Strain | WBStrain00031623 | ||||||||
WBStrain00007212 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (18) | |||||||||
Ortholog (51) | |||||||||
Paralog | WBGene00011454 | Caenorhabditis elegans | From_analysis | Panther | |||||
WormBase-Compara | |||||||||
Structured_description | Concise_description | fshr-1 encodes a putative neuropeptide receptor required for normalacetylcholine secretion by synapses; FSHR-1 is orthologous to humanfollicle-stimulating hormone receptor (OMIM:136435; mutated in ovariandysgenesis), thyrotropin receptor (OMIM:603372; mutated inhyperthyroidism), and luteinizing hormone receptor (OMIM:152790, mutatedin precocious puberty); fshr-1 mutants have abnormally many GFP::SNB-1puncta at synapses, suggesting exocytotic defects; the requirement forFSHR-1 and ten other predicted neuropeptide signalling proteins incholinergic neurotransmission indicates that such signalling isimportant for regulating acetylcholine release at neuromuscularjunctions; possible ligands of FSHR-1 are FLP-1 and NLP-12. | Paper_evidence | WBPaper00026667 | |||||
Curator_confirmed | WBPerson1823 | ||||||||
WBPerson567 | |||||||||
Date_last_updated | 09 Nov 2006 00:00:00 | ||||||||
Automated_description | Predicted to enable G protein-coupled peptide receptor activity. Involved in defense response to other organism; response to oxidative stress; and stress response to cadmium ion. Predicted to be located in plasma membrane. Expressed in intestine; neurons; pharynx; spermatheca; and vulva. Human ortholog(s) of this gene implicated in several diseases, including cystadenocarcinoma (multiple); disorder of sexual development (multiple); and sex cord-gonadal stromal tumor (multiple). Is an ortholog of human FSHR (follicle stimulating hormone receptor) and LHCGR (luteinizing hormone/choriogonadotropin receptor). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model (16) | ||||||||
Molecular_info | Corresponding_CDS | C50H2.1a | |||||||
C50H2.1b | |||||||||
Corresponding_CDS_history | C50H2.1:wp52 | ||||||||
Corresponding_transcript | C50H2.1a.1 | ||||||||
C50H2.1b.1 | |||||||||
Other_sequence | JI171853.1 | ||||||||
Tcol_isotig10998 | |||||||||
JI473293.1 | |||||||||
CJC04547_1 | |||||||||
Tcol_isotig10997 | |||||||||
JI468453.1 | |||||||||
Associated_feature | WBsf647114 | ||||||||
WBsf647115 | |||||||||
WBsf661588 | |||||||||
WBsf232300 | |||||||||
WBsf232301 | |||||||||
Experimental_info | RNAi_result (12) | ||||||||
Expr_pattern | Expr3541 | ||||||||
Expr4567 | |||||||||
Expr7940 | |||||||||
Expr16472 | |||||||||
Expr1012556 | |||||||||
Expr1033582 | |||||||||
Expr1146942 | |||||||||
Expr2011911 | |||||||||
Expr2030148 | |||||||||
Drives_construct | WBCnstr00006333 | ||||||||
WBCnstr00007211 | |||||||||
WBCnstr00007212 | |||||||||
WBCnstr00007213 | |||||||||
WBCnstr00011465 | |||||||||
WBCnstr00013014 | |||||||||
WBCnstr00033124 | |||||||||
WBCnstr00043063 | |||||||||
Construct_product | WBCnstr00006333 | ||||||||
WBCnstr00007211 | |||||||||
WBCnstr00007212 | |||||||||
WBCnstr00007213 | |||||||||
WBCnstr00020873 | |||||||||
WBCnstr00033124 | |||||||||
WBCnstr00041283 | |||||||||
WBCnstr00041284 | |||||||||
WBCnstr00041285 | |||||||||
WBCnstr00043063 | |||||||||
Regulate_expr_cluster | WBPaper00048530:fshr-1(ok778)_PA14_upregulated | ||||||||
WBPaper00048530:fshr-1(ok778)_upregulated | |||||||||
Microarray_results (22) | |||||||||
Expression_cluster (125) | |||||||||
Interaction (38) | |||||||||
WBProcess | WBbiopr:00000039 | ||||||||
Map_info | Map | V | Position | 2.20466 | Error | 0.001111 | |||
Positive | Positive_clone | C50H2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | Multi_point | 5520 | |||||||
5436 | |||||||||
Pseudo_map_position | |||||||||
Reference (45) | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |