WormBase Tree Display for Gene: WBGene00008239
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| WBGene00008239 | SMap | S_parent | Sequence | C50H2 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | fshr-1 | Paper_evidence | WBPaper00026667 | |||||
| Person_evidence | WBPerson1139 | ||||||||
| Sequence_name | C50H2.1 | ||||||||
| Molecular_name | C50H2.1a | ||||||||
| C50H2.1a.1 | |||||||||
| CE28214 | |||||||||
| C50H2.1b | |||||||||
| CE48138 | |||||||||
| C50H2.1b.1 | |||||||||
| Other_name | lgr | Accession_evidence | EMBL | AF224743 | |||||
| CELE_C50H2.1 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | fshr-1 | ||||||||
| DB_info | Database | AceView | gene | 5K373 | |||||
| WormQTL | gene | WBGene00008239 | |||||||
| WormFlux | gene | WBGene00008239 | |||||||
| NDB | locus_tag | CELE_C50H2.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00008239|UniProtKB=L8EC40 | |||||||
| family | PTHR24372 | ||||||||
| NCBI | gene | 179381 | |||||||
| RefSeq | protein | NM_073147.7 | |||||||
| NM_001276924.3 | |||||||||
| TrEMBL | UniProtAcc | L8EC40 | |||||||
| G5EG04 | |||||||||
| UniProt_GCRP | UniProtAcc | L8EC40 | |||||||
| OMIM | gene | 136435 | |||||||
| 152790 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:48 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 12 Sep 2005 16:03:13 | WBPerson2970 | Name_change | CGC_name | fshr-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | fshr | ||||||||
| Allele (65) | |||||||||
| Strain | WBStrain00031623 | ||||||||
| WBStrain00007212 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (18) | |||||||||
| Ortholog (51) | |||||||||
| Paralog | WBGene00011454 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | fshr-1 encodes a putative neuropeptide receptor required for normalacetylcholine secretion by synapses; FSHR-1 is orthologous to humanfollicle-stimulating hormone receptor (OMIM:136435; mutated in ovariandysgenesis), thyrotropin receptor (OMIM:603372; mutated inhyperthyroidism), and luteinizing hormone receptor (OMIM:152790, mutatedin precocious puberty); fshr-1 mutants have abnormally many GFP::SNB-1puncta at synapses, suggesting exocytotic defects; the requirement forFSHR-1 and ten other predicted neuropeptide signalling proteins incholinergic neurotransmission indicates that such signalling isimportant for regulating acetylcholine release at neuromuscularjunctions; possible ligands of FSHR-1 are FLP-1 and NLP-12. | Paper_evidence | WBPaper00026667 | |||||
| Curator_confirmed | WBPerson1823 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 09 Nov 2006 00:00:00 | ||||||||
| Automated_description | Predicted to enable G protein-coupled peptide receptor activity. Involved in defense response to other organism; response to oxidative stress; and stress response to cadmium ion. Predicted to be located in plasma membrane. Expressed in intestine; neurons; pharynx; spermatheca; and vulva. Human ortholog(s) of this gene implicated in several diseases, including cystadenocarcinoma (multiple); disorder of sexual development (multiple); and sex cord-gonadal stromal tumor (multiple). Is an ortholog of human FSHR (follicle stimulating hormone receptor) and LHCGR (luteinizing hormone/choriogonadotropin receptor). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (16) | ||||||||
| Molecular_info | Corresponding_CDS | C50H2.1a | |||||||
| C50H2.1b | |||||||||
| Corresponding_CDS_history | C50H2.1:wp52 | ||||||||
| Corresponding_transcript | C50H2.1a.1 | ||||||||
| C50H2.1b.1 | |||||||||
| Other_sequence | JI171853.1 | ||||||||
| Tcol_isotig10998 | |||||||||
| JI473293.1 | |||||||||
| CJC04547_1 | |||||||||
| Tcol_isotig10997 | |||||||||
| JI468453.1 | |||||||||
| Associated_feature | WBsf647114 | ||||||||
| WBsf647115 | |||||||||
| WBsf661588 | |||||||||
| WBsf232300 | |||||||||
| WBsf232301 | |||||||||
| Experimental_info | RNAi_result (12) | ||||||||
| Expr_pattern | Expr3541 | ||||||||
| Expr4567 | |||||||||
| Expr7940 | |||||||||
| Expr16472 | |||||||||
| Expr1012556 | |||||||||
| Expr1033582 | |||||||||
| Expr1146942 | |||||||||
| Expr2011911 | |||||||||
| Expr2030148 | |||||||||
| Drives_construct | WBCnstr00006333 | ||||||||
| WBCnstr00007211 | |||||||||
| WBCnstr00007212 | |||||||||
| WBCnstr00007213 | |||||||||
| WBCnstr00011465 | |||||||||
| WBCnstr00013014 | |||||||||
| WBCnstr00033124 | |||||||||
| WBCnstr00043063 | |||||||||
| Construct_product | WBCnstr00006333 | ||||||||
| WBCnstr00007211 | |||||||||
| WBCnstr00007212 | |||||||||
| WBCnstr00007213 | |||||||||
| WBCnstr00020873 | |||||||||
| WBCnstr00033124 | |||||||||
| WBCnstr00041283 | |||||||||
| WBCnstr00041284 | |||||||||
| WBCnstr00041285 | |||||||||
| WBCnstr00043063 | |||||||||
| Regulate_expr_cluster | WBPaper00048530:fshr-1(ok778)_PA14_upregulated | ||||||||
| WBPaper00048530:fshr-1(ok778)_upregulated | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (125) | |||||||||
| Interaction | WBInteraction000050841 | ||||||||
| WBInteraction000050842 | |||||||||
| WBInteraction000052700 | |||||||||
| WBInteraction000052701 | |||||||||
| WBInteraction000114275 | |||||||||
| WBInteraction000162600 | |||||||||
| WBInteraction000164450 | |||||||||
| WBInteraction000167720 | |||||||||
| WBInteraction000169865 | |||||||||
| WBInteraction000174125 | |||||||||
| WBInteraction000233128 | |||||||||
| WBInteraction000233163 | |||||||||
| WBInteraction000272831 | |||||||||
| WBInteraction000280493 | |||||||||
| WBInteraction000344046 | |||||||||
| WBInteraction000349645 | |||||||||
| WBInteraction000354521 | |||||||||
| WBInteraction000361956 | |||||||||
| WBInteraction000382122 | |||||||||
| WBInteraction000392059 | |||||||||
| WBInteraction000403023 | |||||||||
| WBInteraction000406220 | |||||||||
| WBInteraction000406467 | |||||||||
| WBInteraction000411016 | |||||||||
| WBInteraction000420238 | |||||||||
| WBInteraction000427604 | |||||||||
| WBInteraction000438704 | |||||||||
| WBInteraction000456265 | |||||||||
| WBInteraction000459125 | |||||||||
| WBInteraction000459539 | |||||||||
| WBInteraction000461115 | |||||||||
| WBInteraction000503896 | |||||||||
| WBInteraction000503897 | |||||||||
| WBInteraction000503898 | |||||||||
| WBInteraction000503899 | |||||||||
| WBInteraction000534831 | |||||||||
| WBInteraction000536172 | |||||||||
| WBInteraction000583590 | |||||||||
| WBProcess | WBbiopr:00000039 | ||||||||
| Map_info | Map | V | Position | 2.20466 | Error | 0.001111 | |||
| Positive | Positive_clone | C50H2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5520 | |||||||
| 5436 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (45) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
