WormBase Tree Display for Interaction: WBInteraction000534831
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| WBInteraction000534831 | Interaction_type | Regulatory | Change_of_expression_level | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00001527 | Interactor_type | Trans_regulated | |
| Transgene | WBTransgene00016444 | ||||
| Construct | WBCnstr00015998 | ||||
| WBGene00008239 | Interactor_type | Trans_regulator | |||
| WBGene00014712 | Interactor_type | Trans_regulator | |||
| Variation_interactor | WBVar00092058 | Interactor_type | Trans_regulator | ||
| Interaction_summary | Wild-type worms induce the intestinal expression of a gcs-1::gfp transcriptional reporter within 5 hours of infection with PA14 (One-way ANOVA, F = 13.33; Tukey HSD test, P<0.01)(Fig 3A, 3B and 3E). Note that this change in gene expression occurs rapidly, before visible physical symptoms appear. In contrast, fshr-1(ok778) mutant worms fail to induce expression of gcs-1::gfp upon PA14 infection (Fig 3C-3E). These data, in combination with the microarray (Fig 1E), indicate that fshr-1 is required for the early activation of the host's protective oxidative stress response upon infection. | ||||
| Detection_method | Construct | ||||
| Transgene | |||||
| Regulation_level | Transcriptional | ||||
| Regulation_result | Positive_regulate | Anatomy_term | WBbt:0005792 | ||
| Paper | WBPaper00048530 |
