WormBase Tree Display for Gene: WBGene00007362

WBGene00007362 SMap: S_parent: Sequence: CHROMOSOME_V
  Identity: Version: 2
    Name: CGC_name: cyp-35C1
      Sequence_name: C06B3.3
      Molecular_name: C06B3.3
        C06B3.3.1
        CE27662
      Other_name: CELE_C06B3.3 Accession_evidence: NDB BX284605
      Public_name: cyp-35C1
    DB_info: Database: AceView gene 5O378
        WormQTL gene WBGene00007362
        WormFlux gene WBGene00007362
        NDB locus_tag CELE_C06B3.3
        Panther gene CAEEL|WormBase=WBGene00007362|UniProtKB=G5ECD0
          family PTHR24300
        NCBI gene 179885
        RefSeq protein NM_171550.6
        TrEMBL UniProtAcc G5ECD0
        UniProt_GCRP UniProtAcc G5ECD0
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:47 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 21 Sep 2004 09:38:16 WBPerson1971 Name_change: CGC_name: cyp-35C1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cyp
    Allele (34)
    Strain: WBStrain00032677
    RNASeq_FPKM (74)
    GO_annotation (15)
    Ortholog: WBGene00052912 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            WormBase-Compara
      WBGene00032559 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            WormBase-Compara
      WBGene00141602 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            WormBase-Compara
      CBOVI.g1868 Caenorhabditis bovis From_analysis: WormBase-Compara
      CBOVI.g1869 Caenorhabditis bovis From_analysis: WormBase-Compara
      CBOVI.g1870 Caenorhabditis bovis From_analysis: WormBase-Compara
      CBOVI.g2007 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP28.g4275 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g10060 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP29.g8027 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP32.g6872 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g6679 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g19893 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g29800 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g6016 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g7640 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cnig_chr_V.g16400 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold629.g14180 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_01040.g17844 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_03720 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_018683 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g02193 Oscheius tipulae From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g06175 Oscheius tipulae From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g06484 Oscheius tipulae From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g07708 Oscheius tipulae From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g10185 Oscheius tipulae From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g10548 Oscheius tipulae From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g10550 Oscheius tipulae From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g12519 Oscheius tipulae From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g14462 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g21319 Panagrellus redivivus From_analysis: WormBase-Compara
      chrV_pilon.g16360 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00288234 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0010383 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            OrthoFinder
            PhylomeDB
      ZFIN:ZDB-GENE-020812-2 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-060818-12 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-030131-4664 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-050522-490 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-031030-8 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-040426-790 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-040426-822 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-040426-1571 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-040426-1584 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-040120-2 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-040120-1 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-110114-2 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-040625-72 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-040704-28 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-041010-37 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-041010-183 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-041001-158 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-040912-139 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-050320-144 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-110114-3 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-071004-47 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-080721-19 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-091211-1 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-041001-156 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-070424-33 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-090312-107 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-070424-41 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-061027-109 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-061027-232 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-080724-3 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-041210-324 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-041001-157 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-061030-1 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-041001-155 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      HGNC:2625 Homo sapiens From_analysis: EnsEMBL-Compara
            OMA
            Panther
            PhylomeDB
      HGNC:2631 Homo sapiens From_analysis: EnsEMBL-Compara
            OMA
            Panther
            PhylomeDB
      HGNC:2632 Homo sapiens From_analysis: EnsEMBL-Compara
            OMA
            Panther
            PhylomeDB
      HGNC:15654 Homo sapiens From_analysis: EnsEMBL-Compara
            OMA
            Panther
            PhylomeDB
      HGNC:20243 Homo sapiens From_analysis: EnsEMBL-Compara
            OMA
            Panther
            PhylomeDB
      MGI:105055 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:88596 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:88597 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:88598 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:88599 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:107303 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:88600 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:103238 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:1306806 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:1306819 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:1306818 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:1306815 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:88602 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:88606 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:88607 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:88608 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:109612 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:1270149 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:1270148 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:1929474 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:1917138 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:1919332 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:1919553 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:1921384 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:1921769 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:1923529 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:2140224 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:2147497 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:2385022 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:3644957 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:2385878 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:1888897 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:2385197 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:3648316 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:3717097 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:3646735 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:88604 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:2686296 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:3642960 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:3612287 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:88603 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:3612288 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:3616076 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:2449816 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:2449817 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:3721049 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:2465 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:2466 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:2472 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:2463 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:2464 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:2470 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:2471 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:2475 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:2477 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:2469 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:620088 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:620379 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:2476 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:620007 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:620370 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:620086 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:620368 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:620363 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:620640 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:708427 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:628627 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:628630 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:1305193 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:735174 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:619934 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:1306078 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:1563215 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:631442 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:2467 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:1563697 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:1561242 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:1586963 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:1596474 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:2320073 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:2319920 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:9404051 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:9160854 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:1564244 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
    Paralog (44)
    Structured_description: Concise_description: cyp-35C1 encodes one of over 80 C. elegans cytochrome P450s, NADPH-dependent monooxygenases that metabolize endogenous and exogenous compounds; RT-PCR experiments indicate that cyp-35C1 mRNA is upregulated in response to treatment with xenobiotics, such as PCBs (polychlorinated biphenyls) or PAHs (polycyclic aromatic hydrocarbons); loss of cyp-35A/C gene family activity in the presence of xenobiotics can diminish the reproductive decline seen in wild-type worms treated with the same compounds. Paper_evidence: WBPaper00025207
          Curator_confirmed: WBPerson1843
          Date_last_updated: 26 Feb 2009 00:00:00
      Automated_description: Predicted to enable heme binding activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; and steroid hydroxylase activity. Involved in response to xenobiotic stimulus. Predicted to be located in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung disease (multiple). Is an ortholog of several human genes including CYP2D6 (cytochrome P450 family 2 subfamily D member 6); CYP2E1 (cytochrome P450 family 2 subfamily E member 1); and CYP2F1 (cytochrome P450 family 2 subfamily F member 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (30)
  Molecular_info: Corresponding_CDS: C06B3.3
    Corresponding_CDS_history: C06B3.3:wp51
    Corresponding_transcript: C06B3.3.1
    Other_sequence (12)
    Associated_feature: WBsf653350
      WBsf234875
  Experimental_info: RNAi_result: WBRNAi00078473 Inferred_automatically: RNAi_primary
      WBRNAi00079025 Inferred_automatically: RNAi_primary
      WBRNAi00028551 Inferred_automatically: RNAi_primary
      WBRNAi00039849 Inferred_automatically: RNAi_primary
      WBRNAi00010275 Inferred_automatically: RNAi_primary
      WBRNAi00078479 Inferred_automatically: RNAi_primary
      WBRNAi00079024 Inferred_automatically: RNAi_primary
      WBRNAi00079023 Inferred_automatically: RNAi_primary
      WBRNAi00092689 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr11593
      Expr1025565
      Expr1033170
      Expr1143931
      Expr2010740
      Expr2028976
    Drives_construct: WBCnstr00019074
      WBCnstr00033800
    Construct_product: WBCnstr00033800
    Microarray_results (19)
    Expression_cluster (311)
    Interaction (27)
  Map_info: Map: V Position: 5.73606 Error: 0.003174
    Positive: Positive_clone: C06B3 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (12)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene