WormBase Tree Display for Gene: WBGene00007362
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WBGene00007362 | SMap | S_parent | Sequence | CHROMOSOME_V | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||||
Name | CGC_name | cyp-35C1 | |||||||
Sequence_name | C06B3.3 | ||||||||
Molecular_name | C06B3.3 | ||||||||
C06B3.3.1 | |||||||||
CE27662 | |||||||||
Other_name | CELE_C06B3.3 | Accession_evidence | NDB | BX284605 | |||||
Public_name | cyp-35C1 | ||||||||
DB_info | Database | AceView | gene | 5O378 | |||||
WormQTL | gene | WBGene00007362 | |||||||
WormFlux | gene | WBGene00007362 | |||||||
NDB | locus_tag | CELE_C06B3.3 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00007362|UniProtKB=G5ECD0 | |||||||
family | PTHR24300 | ||||||||
NCBI | gene | 179885 | |||||||
RefSeq | protein | NM_171550.6 | |||||||
TrEMBL | UniProtAcc | G5ECD0 | |||||||
UniProt_GCRP | UniProtAcc | G5ECD0 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 26 May 2004 16:54:47 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
2 | 21 Sep 2004 09:38:16 | WBPerson1971 | Name_change | CGC_name | cyp-35C1 | ||||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | cyp | ||||||||
Allele (34) | |||||||||
Strain | WBStrain00032677 | ||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (15) | |||||||||
Ortholog (157) | |||||||||
Paralog (44) | |||||||||
Structured_description | Concise_description | cyp-35C1 encodes one of over 80 C. elegans cytochrome P450s, NADPH-dependent monooxygenases that metabolize endogenous and exogenous compounds; RT-PCR experiments indicate that cyp-35C1 mRNA is upregulated in response to treatment with xenobiotics, such as PCBs (polychlorinated biphenyls) or PAHs (polycyclic aromatic hydrocarbons); loss of cyp-35A/C gene family activity in the presence of xenobiotics can diminish the reproductive decline seen in wild-type worms treated with the same compounds. | Paper_evidence | WBPaper00025207 | |||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 26 Feb 2009 00:00:00 | ||||||||
Automated_description | Predicted to enable heme binding activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; and steroid hydroxylase activity. Involved in response to xenobiotic stimulus. Predicted to be located in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung disease (multiple). Is an ortholog of several human genes including CYP2D6 (cytochrome P450 family 2 subfamily D member 6); CYP2E1 (cytochrome P450 family 2 subfamily E member 1); and CYP2F1 (cytochrome P450 family 2 subfamily F member 1). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model (30) | ||||||||
Molecular_info | Corresponding_CDS | C06B3.3 | |||||||
Corresponding_CDS_history | C06B3.3:wp51 | ||||||||
Corresponding_transcript | C06B3.3.1 | ||||||||
Other_sequence (12) | |||||||||
Associated_feature | WBsf653350 | ||||||||
WBsf234875 | |||||||||
Experimental_info | RNAi_result | WBRNAi00078473 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00079025 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00028551 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00039849 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00010275 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00078479 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00079024 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00079023 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00092689 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern | Expr11593 | ||||||||
Expr1025565 | |||||||||
Expr1033170 | |||||||||
Expr1143931 | |||||||||
Expr2010740 | |||||||||
Expr2028976 | |||||||||
Drives_construct | WBCnstr00019074 | ||||||||
WBCnstr00033800 | |||||||||
Construct_product | WBCnstr00033800 | ||||||||
Microarray_results (19) | |||||||||
Expression_cluster (311) | |||||||||
Interaction (27) | |||||||||
Map_info | Map | V | Position | 5.73606 | Error | 0.003174 | |||
Positive | Positive_clone | C06B3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Pseudo_map_position | |||||||||
Reference (12) | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |