WormBase Tree Display for Gene: WBGene00007362

WBGene00007362 SMap: S_parent: Sequence: CHROMOSOME_V
  Identity: Version: 2
    Name: CGC_name: cyp-35C1
      Sequence_name: C06B3.3
      Molecular_name: C06B3.3
        C06B3.3.1
        CE27662
      Other_name: CELE_C06B3.3 Accession_evidence: NDB BX284605
      Public_name: cyp-35C1
    DB_info: Database: AceView gene 5O378
        WormQTL gene WBGene00007362
        WormFlux gene WBGene00007362
        NDB locus_tag CELE_C06B3.3
        Panther gene CAEEL|WormBase=WBGene00007362|UniProtKB=G5ECD0
          family PTHR24300
        NCBI gene 179885
        RefSeq protein NM_171550.6
        TrEMBL UniProtAcc G5ECD0
        UniProt_GCRP UniProtAcc G5ECD0
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:47 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 21 Sep 2004 09:38:16 WBPerson1971 Name_change: CGC_name: cyp-35C1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cyp
    Allele (34)
    Strain: WBStrain00032677
    RNASeq_FPKM (74)
    GO_annotation (15)
    Ortholog (157)
    Paralog (44)
    Structured_description: Concise_description: cyp-35C1 encodes one of over 80 C. elegans cytochrome P450s, NADPH-dependent monooxygenases that metabolize endogenous and exogenous compounds; RT-PCR experiments indicate that cyp-35C1 mRNA is upregulated in response to treatment with xenobiotics, such as PCBs (polychlorinated biphenyls) or PAHs (polycyclic aromatic hydrocarbons); loss of cyp-35A/C gene family activity in the presence of xenobiotics can diminish the reproductive decline seen in wild-type worms treated with the same compounds. Paper_evidence: WBPaper00025207
          Curator_confirmed: WBPerson1843
          Date_last_updated: 26 Feb 2009 00:00:00
      Automated_description: Predicted to enable heme binding activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; and steroid hydroxylase activity. Involved in response to xenobiotic stimulus. Predicted to be located in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung disease (multiple). Is an ortholog of several human genes including CYP2D6 (cytochrome P450 family 2 subfamily D member 6); CYP2E1 (cytochrome P450 family 2 subfamily E member 1); and CYP2F1 (cytochrome P450 family 2 subfamily F member 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (30)
  Molecular_info: Corresponding_CDS: C06B3.3
    Corresponding_CDS_history: C06B3.3:wp51
    Corresponding_transcript: C06B3.3.1
    Other_sequence (12)
    Associated_feature: WBsf653350
      WBsf234875
  Experimental_info: RNAi_result: WBRNAi00078473 Inferred_automatically: RNAi_primary
      WBRNAi00079025 Inferred_automatically: RNAi_primary
      WBRNAi00028551 Inferred_automatically: RNAi_primary
      WBRNAi00039849 Inferred_automatically: RNAi_primary
      WBRNAi00010275 Inferred_automatically: RNAi_primary
      WBRNAi00078479 Inferred_automatically: RNAi_primary
      WBRNAi00079024 Inferred_automatically: RNAi_primary
      WBRNAi00079023 Inferred_automatically: RNAi_primary
      WBRNAi00092689 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr11593
      Expr1025565
      Expr1033170
      Expr1143931
      Expr2010740
      Expr2028976
    Drives_construct: WBCnstr00019074
      WBCnstr00033800
    Construct_product: WBCnstr00033800
    Microarray_results (19)
    Expression_cluster (311)
    Interaction (27)
  Map_info: Map: V Position: 5.73606 Error: 0.003174
    Positive: Positive_clone: C06B3 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00004966
    WBPaper00025207
    WBPaper00026820
    WBPaper00028527
    WBPaper00032604
    WBPaper00033099
    WBPaper00038491
    WBPaper00043206
    WBPaper00044018
    WBPaper00059129
    WBPaper00062515
    WBPaper00064093
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene