WormBase Tree Display for Gene: WBGene00006999

WBGene00006999 Evidence: Paper_evidence: WBPaper00005583
  SMap: S_parent: Sequence: F42G4
  Identity: Version: 1
    Name: CGC_name: zyx-1 Person_evidence: WBPerson57
      Sequence_name: F42G4.3
      Molecular_name (15)
      Other_name: CELE_F42G4.3 Accession_evidence: NDB BX284602
      Public_name: zyx-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:44 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: zyx
    Allele (371)
    Possibly_affected_by: WBVar02156836
      WBVar02159005
    Strain: WBStrain00002902
      WBStrain00002940
      WBStrain00031658
      WBStrain00035659
      WBStrain00036164
    RNASeq_FPKM (74)
    GO_annotation (29)
    Ortholog (44)
    Structured_description: Concise_description: zyx-1 encodes a LIM domain protein and is most similar to vertebrate Zyxin; the vertebrate zyxin sub-family also includes migfilin, TRIP6 and LPP; the ZYX-1 protein is expressed in striated body wall muscle and localizes at dense bodies/Z-discs and in the nucleus; ZYX-1 physically interacts with P granule components (GLH proteins) and several dense body and M-line proteins, including DEB-1 (Vinculin) and ATN-1 (alpha-actinin), indicating that zyx-1 may play a role in anchoring actin filaments to dense bodies via its interaction with these proteins. Paper_evidence: WBPaper00005583
            WBPaper00042056
          Curator_confirmed: WBPerson324
            WBPerson1823
            WBPerson567
          Date_last_updated: 12 Mar 2013 00:00:00
      Automated_description: Enables DEAD/H-box RNA helicase binding activity. Involved in maintenance of synapse structure. Acts upstream of or within with a positive effect on smooth muscle contraction. Located in M band; nucleus; and striated muscle dense body. Expressed in muscle cell and neurons. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Is an ortholog of human LPP (LIM domain containing preferred translocation partner in lipoma) and TRIP6 (thyroid hormone receptor interactor 6). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:9119 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6679)
  Molecular_info: Corresponding_CDS: F42G4.3a
      F42G4.3b
      F42G4.3c
      F42G4.3d
      F42G4.3e
    Corresponding_CDS_history: F42G4.3b:wp229
    Corresponding_transcript: F42G4.3a.1
      F42G4.3b.1
      F42G4.3c.1
      F42G4.3d.1
      F42G4.3e.1
    Other_sequence (102)
    Associated_feature (27)
    Transcription_factor: WBTranscriptionFactor000281
  Experimental_info: RNAi_result (17)
    Expr_pattern (13)
    Drives_construct: WBCnstr00003418
      WBCnstr00003446
      WBCnstr00013255
      WBCnstr00017561
      WBCnstr00034046
    Construct_product: WBCnstr00013255
      WBCnstr00017408
      WBCnstr00017561
      WBCnstr00020064
      WBCnstr00020065
      WBCnstr00020066
      WBCnstr00020067
      WBCnstr00020483
      WBCnstr00034046
    Antibody: WBAntibody00002404
      WBAntibody00002405
      WBAntibody00002406
    Microarray_results (35)
    Expression_cluster: WBPaper00031040:Cluster_3
      WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00032528:L3_enriched
      WBPaper00033065:clk-1(qm30)_upregulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037055:DAF-16_binding_DNA
      WBPaper00037946:LIN-39_interacting
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_CoreEnriched
      WBPaper00037950:dopaminergic-neurons_embryo_enriched
      WBPaper00037950:dopaminergic-neurons_embryo_SelectivelyEnriched
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:dopaminergic-neurons_larva_enriched
      WBPaper00037950:dopaminergic-neurons_larva_SelectivelyEnriched
      WBPaper00037950:GABAergic-motor-neurons_embryo_enriched
      WBPaper00037950:GABAergic-motor-neurons_embryo_SelectivelyEnriched
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038118:aak-2(gt33)_upregulated
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00041222:unc-120(st364)_downregulated
      WBPaper00042561:smgl-1(RNAi)_upregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
      WBPaper00044786:lem-2(tm1582)_upregulated
      WBPaper00045316:prg-1_upregulated_L1
      WBPaper00045316:prg-1_upregulated_L2
      WBPaper00045316:prg-1_upregulated_L3
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00046121:mesoderm_unique
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00047132:glp-1(ts)-25C_upregulated
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
      WBPaper00049920:Glucose-Diet_upregulated_N2
      WBPaper00050053:muscle_enriched_Day4
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050412:cco-1(RNAi)_upregulated_N2
      WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:body-wall-muscle_specific
      WBPaper00051558:aging_regulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053318:Aging_downregulated_mRNA_N2
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053388:dauer_regulated_Cluster4
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00053814:25C_downregulated_OP50
      WBPaper00055049:S.gordonii_downregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Psora_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055482:Tunicamycin_downregulated
      WBPaper00055648:male-vas-deferens_expressed
      WBPaper00055827:pfd-6(gk493446)_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056161:male_enriched_siRNA
      WBPaper00056275:P.aeruginosa_downregulated
      WBPaper00056443:DietaryRestriction_downregulated
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00056826:hmc_biased
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058958:100mGy-irradiation-72h_upregulated
      WBPaper00059471:EGL-43_interacting
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059763:neuron_expressed
      WBPaper00059824:rnp-6(dh1127)_regulated_OP50
      WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
      WBPaper00060100:SiNP_upregulated_mRNA
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061040:FW1256_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:ALM_PLM
      WBPaper00061340:DA_DB
      WBPaper00061340:mu_int_mu_anal
      WBPaper00061340:RIV
      WBPaper00061340:Y
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
      WBPaper00061479:ubc-9(ne4833)_upregulated
      WBPaper00061527:mup-2-unc-87_284
      WBPaper00061651:ALM_enriched
      WBPaper00061651:AS_enriched
      WBPaper00061651:AVA_enriched
      WBPaper00061651:CEP_enriched
      WBPaper00061651:DA_enriched
      WBPaper00061651:DB_enriched
      WBPaper00061651:PDA_enriched
      WBPaper00061651:PLM_enriched
      WBPaper00061651:PVM_enriched
      WBPaper00061651:PVR_enriched
      WBPaper00061651:PVW_enriched
      WBPaper00061651:RME_DV_enriched
      WBPaper00061651:SAA_enriched
      WBPaper00061651:SAB_enriched
      WBPaper00061651:SIA_enriched
      WBPaper00061651:SMB_enriched
      WBPaper00061651:SMD_enriched
      WBPaper00061651:Spermatheca_enriched
      WBPaper00061651:URA_enriched
      WBPaper00061651:VA12_enriched
      WBPaper00061651:VA_enriched
      WBPaper00061651:VB01_enriched
      WBPaper00061651:VB02_enriched
      WBPaper00061651:VB_enriched
      WBPaper00061818:ELKS-1_interacting
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:hsf-1(RNAi)_upregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062590:Aging_downregulated_hypodermis
      WBPaper00063930:BRD-1_interacting
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064716:paraquat_downregulated
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00064789:Day3_vs_Day1_downregulated_neuron
      WBPaper00064789:Day6_vs_Day1_downregulated_neuron
      WBPaper00064933:E.coli-binding_secret_protein
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065373:sek-1(km4)_downregulated_cisplatin
      WBPaper00065623:33
      WBPaper00065835:Day5_vs_Day1_downregulated
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065841:6_0
      WBPaper00065841:6_1
      WBPaper00065841:6_2
      WBPaper00065841:6_3
      WBPaper00065841:14_0
      WBPaper00065841:14_1
      WBPaper00065841:32_0
      WBPaper00065841:36_0
      WBPaper00065841:46_0
      WBPaper00065841:115_0
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      cgc4386_cluster_3_5
      cgc4489_group_20
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00031003:hlh_1_enriched
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00031832:slr-2_regulated
      WBPaper00034661:AgNPs_downregulated
      WBPaper00035560:ahr-1_downregulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00036123:Cadmium_regulated
      WBPaper00037695:LD_DD_6-day
      WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up
      WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
      WBPaper00040426:CYD-1_CDK-4_downregulated
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_old
      WBPaper00040985:AIN-2_asynchronous_muscle
      WBPaper00041002:HF_3d_0.2mM_Up
      WBPaper00041002:HF_3d_2.0mM_Up
      WBPaper00041174:environmental
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_and_environmental
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041906:I-3690_vs_OP50_3d
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
      WBPaper00042258:DA1877_upregulated_GravidAdult
      [cgc6390]:Cluster_C
      [cgc6390]:male_soma-enriched
    Interaction (74)
  Map_info: Map: II Position: 13.979 Error: 0.069963
    Positive: Positive_clone: F42G4 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4247
        4770
        4980
    Pseudo_map_position
  Reference (27)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene