WormBase Tree Display for Gene: WBGene00006876
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| WBGene00006876 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | CHROMOSOME_I | ||||||
| Identity | Version | 5 | |||||||
| Name (5) | |||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 04 Jun 2007 09:44:12 | WBPerson1983 | Event | Acquires_merge | WBGene00009970 | ||||
| 3 | 12 Jul 2011 11:57:39 | WBPerson2970 | Event | Acquires_merge | WBGene00044919 | ||||
| Name_change | Other_name | mig-31 | |||||||
| 4 | 21 Nov 2019 16:12:41 | WBPerson4025 | Event | Acquires_merge | WBGene00011384 | ||||
| 5 | 21 Nov 2019 16:12:41 | WBPerson4025 | Event | Acquires_merge | WBGene00011385 | ||||
| Acquires_merge | WBGene00009970 | ||||||||
| WBGene00044919 | |||||||||
| WBGene00011384 | |||||||||
| WBGene00011385 | |||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | vab | ||||||||
| Reference_allele | WBVar00143414 | ||||||||
| Allele (1092) | |||||||||
| Legacy_information | e698 : degenerate head bent dorsally or ventrally penetrance 50%; generally poor growth; adult male tail invariably thin fan and rays reduced in size. ES3/1 ME0. NA1. | ||||||||
| See also e698 | |||||||||
| [C.elegansII] e698 : degenerate head, bent dorsally or ventrally; penetrance 50%; generally poor growth; adult male tail invariably thin fan and rays reduced in size; Mua (defective muscle attachment). ES3/1 ME0. NA1. [Hodgkin 1974; NJ] | |||||||||
| Strain | WBStrain00026573 | ||||||||
| WBStrain00026574 | |||||||||
| WBStrain00035519 | |||||||||
| WBStrain00035910 | |||||||||
| WBStrain00004199 | |||||||||
| WBStrain00007880 | |||||||||
| WBStrain00007881 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (25) | |||||||||
| Ortholog (54) | |||||||||
| Paralog (13) | |||||||||
| Structured_description | Concise_description | vab-10 encodes, by alternative splicing, two spectraplakins (VAB-10A and VAB-10B) that are jointly required for mechanical resilience of the epidermis under strain by the contraction of actin microfilaments mechanically linked to fibrous organelles (FOs); VAB-10A/B are, accordingly, required for elongation during embryonic morphogenesis; VAB-10A has C-terminal plectin repeats while VAB-10B has spectrin repeats; VAB-10A is required to keep the epidermis and extracellular matrix attached via FOs, while VAB-10B is required to keep the apical and basal epidermal plasma membranes connected during morphogenesis; vab-10a and vab-10b mutations complement one another; vab-10 is orthologous to human BPAG1 (dystonin or MACF2, OMIM:113810, encoding an autoantigen of bullous pemphigoid blistering disease) and dJ562N20.1 (MACF1), and to Drosophila SHORT STOP. | Paper_evidence | WBPaper00000608 | |||||
| WBPaper00003943 | |||||||||
| WBPaper00005913 | |||||||||
| WBPaper00013151 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable actin filament binding activity and structural molecule activity. Involved in epidermis morphogenesis. Located in apical plasma membrane; basal plasma membrane; and hemidesmosome. Expressed in several structures, including gonad; intestinal lumen; nerve ring; pharynx; and vulval cell. Human ortholog(s) of this gene implicated in epidermolysis bullosa simplex; hereditary sensory and autonomic neuropathy type 6; and lissencephaly 9 with complex brainstem malformation. Is an ortholog of human DST (dystonin). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0070151 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1090) | ||||
| DOID:0112228 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13664) | ||||||
| DOID:4644 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1090) | ||||||
| Molecular_info | Corresponding_CDS (14) | ||||||||
| Corresponding_CDS_history | ZK1151.1:wp100 | ||||||||
| ZK1151.1a:wp274 | |||||||||
| ZK1151.1b:wp274 | |||||||||
| ZK1151.1c:wp274 | |||||||||
| ZK1151.1d:wp274 | |||||||||
| ZK1151.1e:wp274 | |||||||||
| ZK1151.1f:wp274 | |||||||||
| ZK1151.1g:wp274 | |||||||||
| Corresponding_transcript (14) | |||||||||
| Other_sequence (147) | |||||||||
| Associated_feature (93) | |||||||||
| Experimental_info | RNAi_result (65) | ||||||||
| Expr_pattern (23) | |||||||||
| Construct_product | WBCnstr00007874 | ||||||||
| WBCnstr00007875 | |||||||||
| WBCnstr00007914 | |||||||||
| WBCnstr00008020 | |||||||||
| WBCnstr00009003 | |||||||||
| WBCnstr00015611 | |||||||||
| WBCnstr00016037 | |||||||||
| WBCnstr00039942 | |||||||||
| Antibody | WBAntibody00000627 | ||||||||
| WBAntibody00002122 | |||||||||
| WBAntibody00002270 | |||||||||
| WBAntibody00002271 | |||||||||
| WBAntibody00002272 | |||||||||
| WBAntibody00002818 | |||||||||
| Microarray_results (115) | |||||||||
| Expression_cluster (290) | |||||||||
| Interaction (156) | |||||||||
| WBProcess | WBbiopr:00000006 | ||||||||
| WBbiopr:00000008 | |||||||||
| Map_info | Map | I | Position | 9.6157 | Error | 0.240987 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | ZK1151 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | 2_point | 646 | |||||||
| 647 | |||||||||
| Multi_point | 566 | ||||||||
| 567 | |||||||||
| 4467 | |||||||||
| 5678 | |||||||||
| Reference (66) | |||||||||
| Remark | Sequence connection from [Hapiak V, Plenefisch JD] | ||||||||
| Method | Gene |
