WormBase Tree Display for Gene: WBGene00006832
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| WBGene00006832 | SMap | S_parent | Sequence | C41C4 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | unc-105 | Person_evidence | WBPerson261 | |||||
| Sequence_name | C41C4.5 | ||||||||
| Molecular_name (19) | |||||||||
| Other_name | CELE_C41C4.5 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | unc-105 | ||||||||
| DB_info | Database | WormQTL | gene | WBGene00006832 | |||||
| WormFlux | gene | WBGene00006832 | |||||||
| NDB | locus_tag | CELE_C41C4.5 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006832|UniProtKB=Q09274 | |||||||
| family | PTHR11690 | ||||||||
| NCBI | gene | 174306 | |||||||
| RefSeq | protein | NM_001381518.2 | |||||||
| NM_001129123.3 | |||||||||
| NM_001377828.2 | |||||||||
| NM_001267210.3 | |||||||||
| NM_063301.6 | |||||||||
| NM_001381517.1 | |||||||||
| SwissProt | UniProtAcc | Q09274 | |||||||
| TrEMBL | UniProtAcc | H2FLF8 | |||||||
| H2FLF9 | |||||||||
| H2FLG0 | |||||||||
| E5QCG1 | |||||||||
| UniProt_GCRP | UniProtAcc | Q09274 | |||||||
| OMIM | gene | 600760 | |||||||
| 600761 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 09 Jan 2012 14:54:53 | WBPerson1983 | Event | Acquires_merge | WBGene00077665 | ||||
| Acquires_merge | WBGene00077665 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Allele (115) | |||||||||
| Legacy_information | Class 3 (neomorphic) alleles n490sd : small hypercontracted rigid paralytic; very poor growth; abnormal muscle structure; n490/+ similar less severe phenotype. ES3. NA (dominant) 3 (n506 (ME0) n1274). Class 1 (loss-of-function) alleles; intragenic revertants of Class 3 alleles are probably null alleles e.g. n490n804 : wildtype phenotype no behavioral or muscular abnormality. NA (Class 1) > 10. Class 3 alleles also suppressed by mutations in unc-15 unc-22 unc-45 unc- 54 etc. | ||||||||
| See also n490, n506, n785, n786, n787, n788, n795, n796, n797, n798, n799, n801, n802, n803, n804, n805, n806, n807, n808, n809, n810, n811, n812, n813, n814, n815, n816, n817, n818, n819, n820 | |||||||||
| [Reiner D]] Mac-h (Hyper-ACtivate Muscle) | |||||||||
| [C.elegansII] n490sd : small, hypercontracted, rigid paralytic; very poor growth; abnormal muscle structure. Muscle hyperactivated, sticky pumping, short.n490/+ similar but less severe phenotype. Probable neomorphic gf allele. Suppressed by mutations in unc-15, unc-22, unc-45, unc-54etc. See also sup-20.ES3. OA2 (gf): n506 (less severe; ME0), n1274. Also intragenic revertants: n490n804 (WT, no behavioral or muscular abnormality; probable null phenotype), n490n820 etc. OA>10 (ird). Cloned: encodes degenerin family member,related to amiloride-sensitive Na channels. [Park and Horvitz 1986b; MT; RW] | |||||||||
| Strain | WBStrain00026795 | ||||||||
| WBStrain00026888 | |||||||||
| WBStrain00026889 | |||||||||
| WBStrain00026890 | |||||||||
| WBStrain00026891 | |||||||||
| WBStrain00027003 | |||||||||
| WBStrain00032015 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (21) | |||||||||
| Ortholog | WBGene00024093 | Caenorhabditis briggsae | From_analysis | OrthoMCL | |||||
| Inparanoid_8 | |||||||||
| WormBase-Compara | |||||||||
| WBGene00212193 | Caenorhabditis japonica | From_analysis | TreeFam | ||||||
| WBGene00054087 | Caenorhabditis remanei | From_analysis | TreeFam | ||||||
| WBGene00193474 | Caenorhabditis brenneri | From_analysis | TreeFam | ||||||
| WBGene00193948 | Caenorhabditis brenneri | From_analysis | TreeFam | ||||||
| WBGene00161303 | Caenorhabditis brenneri | From_analysis | Inparanoid_8 | ||||||
| WormBase-Compara | |||||||||
| WBGene00053790 | Caenorhabditis remanei | From_analysis | Inparanoid_8 | ||||||
| WormBase-Compara | |||||||||
| WBGene00053789 | Caenorhabditis remanei | From_analysis | Inparanoid_7 | ||||||
| WBGene00222950 | Brugia malayi | From_analysis | WormBase-Compara | ||||||
| CBOVI.g6823 | Caenorhabditis bovis | From_analysis | WormBase-Compara | ||||||
| CSP21.g16118 | Caenorhabditis parvicauda | From_analysis | WormBase-Compara | ||||||
| CSP26.g6515 | Caenorhabditis zanzibari | From_analysis | WormBase-Compara | ||||||
| CSP28.g12831 | Caenorhabditis panamensis | From_analysis | WormBase-Compara | ||||||
| CSP29.g6442 | Caenorhabditis becei | From_analysis | WormBase-Compara | ||||||
| CSP31.g9396 | Caenorhabditis uteleia | From_analysis | WormBase-Compara | ||||||
| CSP32.g3445 | Caenorhabditis sulstoni | From_analysis | WormBase-Compara | ||||||
| CSP38.g13214 | Caenorhabditis quiockensis | From_analysis | WormBase-Compara | ||||||
| CSP39.g6617 | Caenorhabditis waitukubuli | From_analysis | WormBase-Compara | ||||||
| CSP40.g19243 | Caenorhabditis tribulationis | From_analysis | WormBase-Compara | ||||||
| Cang_2012_03_13_00115.g4756 | Caenorhabditis angaria | From_analysis | WormBase-Compara | ||||||
| Cang_2012_03_13_02515.g17272 | Caenorhabditis angaria | From_analysis | WormBase-Compara | ||||||
| Cni-unc-105 | Caenorhabditis nigoni | From_analysis | WormBase-Compara | ||||||
| Csp11.Scaffold630.g18496 | Caenorhabditis tropicalis | From_analysis | WormBase-Compara | ||||||
| Csp5_scaffold_01896.g23753 | Caenorhabditis sinica | From_analysis | WormBase-Compara | ||||||
| FL83_08787 | Caenorhabditis latens | From_analysis | WormBase-Compara | ||||||
| OTIPU.nOt.2.0.1.g09363 | Oscheius tipulae | From_analysis | WormBase-Compara | ||||||
| Pan_g20789 | Panagrellus redivivus | From_analysis | WormBase-Compara | ||||||
| Sp34_20152800 | Caenorhabditis inopinata | From_analysis | WormBase-Compara | ||||||
| chrII_pilon.g5163 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00247051 | Onchocerca volvulus | From_analysis | WormBase-Compara | ||||||
| WBGene00099877 | Pristionchus pacificus | From_analysis | WormBase-Compara | ||||||
| WBGene00265038 | Strongyloides ratti | From_analysis | WormBase-Compara | ||||||
| ZFIN:ZDB-GENE-040513-6 | Danio rerio | From_analysis | Inparanoid | ||||||
| OrthoInspector | |||||||||
| SonicParanoid | |||||||||
| ZFIN:ZDB-GENE-040513-5 | Danio rerio | From_analysis | Inparanoid | ||||||
| OrthoInspector | |||||||||
| SonicParanoid | |||||||||
| ZFIN:ZDB-GENE-040513-4 | Danio rerio | From_analysis | Inparanoid | ||||||
| OrthoInspector | |||||||||
| SonicParanoid | |||||||||
| ZFIN:ZDB-GENE-040513-3 | Danio rerio | From_analysis | Inparanoid | ||||||
| OrthoInspector | |||||||||
| SonicParanoid | |||||||||
| ZFIN:ZDB-GENE-040513-1 | Danio rerio | From_analysis | Inparanoid | ||||||
| OrthoInspector | |||||||||
| SonicParanoid | |||||||||
| ZFIN:ZDB-GENE-040513-2 | Danio rerio | From_analysis | Inparanoid | ||||||
| OrthoInspector | |||||||||
| SonicParanoid | |||||||||
| HGNC:10600 | Homo sapiens | From_analysis | Hieranoid | ||||||
| Inparanoid | |||||||||
| OrthoFinder | |||||||||
| OrthoInspector | |||||||||
| PhylomeDB | |||||||||
| SonicParanoid | |||||||||
| HGNC:10601 | Homo sapiens | From_analysis | Hieranoid | ||||||
| Inparanoid | |||||||||
| OrthoFinder | |||||||||
| OrthoInspector | |||||||||
| PhylomeDB | |||||||||
| SonicParanoid | |||||||||
| HGNC:10602 | Homo sapiens | From_analysis | Hieranoid | ||||||
| Inparanoid | |||||||||
| OrthoFinder | |||||||||
| OrthoInspector | |||||||||
| PhylomeDB | |||||||||
| SonicParanoid | |||||||||
| MGI:104695 | Mus musculus | From_analysis | Hieranoid | ||||||
| Inparanoid | |||||||||
| OrthoFinder | |||||||||
| OrthoInspector | |||||||||
| PhylomeDB | |||||||||
| SonicParanoid | |||||||||
| RGD:3640 | Rattus norvegicus | From_analysis | Hieranoid | ||||||
| Inparanoid | |||||||||
| OrthoFinder | |||||||||
| OrthoInspector | |||||||||
| PhylomeDB | |||||||||
| SonicParanoid | |||||||||
| RGD:3641 | Rattus norvegicus | From_analysis | Hieranoid | ||||||
| Inparanoid | |||||||||
| OrthoFinder | |||||||||
| OrthoInspector | |||||||||
| PhylomeDB | |||||||||
| SonicParanoid | |||||||||
| RGD:3639 | Rattus norvegicus | From_analysis | Hieranoid | ||||||
| Inparanoid | |||||||||
| OrthoFinder | |||||||||
| OrthoInspector | |||||||||
| PhylomeDB | |||||||||
| SonicParanoid | |||||||||
| Paralog (30) | |||||||||
| Structured_description | Concise_description | unc-105 encodes a muscle degenerin, a mechanosensory membrane channel that is a member of the degenerin ion channel superfamily and similar to subunits of the mammalian amiloride-sensitive epithelial sodium channel (ENaC, OMIM:600761); UNC-105 is required for normal growth and for normal contraction and organization of muscle, where it is expressed; UNC-105 interacts with LET-2, an alpha2 chain of type IV collagen that is also expressed by muscle and localized to the basement membrane between muscle and hypodermis. | Paper_evidence | WBPaper00000715 | |||||
| WBPaper00002489 | |||||||||
| WBPaper00002490 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables monoatomic ion channel activity. Involved in calcium ion transport; magnesium ion transport; and muscle organ development. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in bronchiectasis (multiple) and renal tubular transport disease (multiple). Is an ortholog of human SCNN1B (sodium channel epithelial 1 subunit beta); SCNN1D (sodium channel epithelial 1 subunit delta); and SCNN1G (sodium channel epithelial 1 subunit gamma). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0080526 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10600) | ||||
| DOID:0050477 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10600,HGNC:10602) | ||||||
| DOID:4479 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10600,HGNC:10602) | ||||||
| DOID:0080528 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10602) | ||||||
| Molecular_info | Corresponding_CDS | C41C4.5a | |||||||
| C41C4.5b | |||||||||
| C41C4.5c | |||||||||
| C41C4.5d | |||||||||
| C41C4.5e | |||||||||
| C41C4.5h | |||||||||
| Corresponding_CDS_history | C41C4.5e:wp274 | ||||||||
| C41C4.5f:wp274 | |||||||||
| C41C4.5g:wp274 | |||||||||
| Corresponding_transcript | C41C4.5a.1 | ||||||||
| C41C4.5b.1 | |||||||||
| C41C4.5c.1 | |||||||||
| C41C4.5c.2 | |||||||||
| C41C4.5d.1 | |||||||||
| C41C4.5e.1 | |||||||||
| C41C4.5h.1 | |||||||||
| Other_sequence | Oden_isotig26078 | ||||||||
| MH07095 | |||||||||
| Oden_isotig19678 | |||||||||
| JI175583.1 | |||||||||
| JI170191.1 | |||||||||
| Name_isotig03641 | |||||||||
| Dviv_isotig27200 | |||||||||
| GO239869.1 | |||||||||
| Associated_feature | WBsf644440 | ||||||||
| WBsf654898 | |||||||||
| WBsf657933 | |||||||||
| WBsf988656 | |||||||||
| WBsf988657 | |||||||||
| WBsf1012649 | |||||||||
| WBsf221685 | |||||||||
| WBsf221686 | |||||||||
| WBsf221687 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00029717 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00011833 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00042279 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00090191 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00109150 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00089804 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00042278 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00090032 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00090350 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1021485 | ||||||||
| Expr1032895 | |||||||||
| Expr1146269 | |||||||||
| Expr2017835 | |||||||||
| Expr2035971 | |||||||||
| Drives_construct | WBCnstr00034129 | ||||||||
| Construct_product | WBCnstr00034129 | ||||||||
| Microarray_results (37) | |||||||||
| Expression_cluster (123) | |||||||||
| Interaction (54) | |||||||||
| WBProcess | WBbiopr:00000002 | ||||||||
| Map_info | Map | II | Position | 0.689401 | Error | 0.004244 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | C41C4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | 2_point | 778 | |||||||
| 779 | |||||||||
| 780 | |||||||||
| Multi_point (11) | |||||||||
| Pos_neg_data | 1362 | ||||||||
| 1430 | |||||||||
| 1435 | |||||||||
| 1440 | |||||||||
| 1445 | |||||||||
| 1449 | |||||||||
| 1453 | |||||||||
| 1486 | |||||||||
| Reference (67) | |||||||||
| Method | Gene |
