Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.

WormBase Tree Display for Gene: WBGene00006822

expand all nodes | collapse all nodes | view schema

Name Class

WBGene00006822SMapS_parentSequenceC46F11
IdentityVersion1
NameCGC_nameunc-93Person_evidenceWBPerson261
Sequence_nameC46F11.1
Molecular_nameC46F11.1a
C46F11.1a.1
CE30906
C46F11.1b
CE37957
C46F11.1b.1
Other_nameCELE_C46F11.1Accession_evidenceNDBBX284603
Public_nameunc-93
DB_infoDatabaseWormQTLgeneWBGene00006822
WormFluxgeneWBGene00006822
NDBlocus_tagCELE_C46F11.1
PanthergeneCAEEL|WormBase=WBGene00006822|UniProtKB=Q93380
familyPTHR19444
NCBIgene175466
RefSeqproteinNM_001026047.5
NM_001381807.1
SwissProtUniProtAccQ93380
TREEFAMTREEFAM_IDTF314905
UniProt_GCRPUniProtAccQ93380
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:43WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classunc
Reference_alleleWBVar00144047
Allele (189)
Legacy_informationClass 3 allele e1500sd : adults paralysed Egl; slightly long; abnormal muscle; contract and relax when prodded (`rubber-band' phenotype). ES3 ME0. Poor mating in e1500/+ males. NA (Class 3) 2 (n200 : resembles e1500 but less severe phenotype). Class 1 (loss-of-function) alleles n392 : no phenotype alone but fails to complement e1500. Intragenic revertants of e1500 all have Class 1 phenotype probably null alleles e.g. e1500n234amber. NA (Class 1) > 30. See also sup-9 sup-10 sup-11 sup-18.
See also n192, n200, n201, n202, n203, n204, n205, n206, n207, n208, n209, n210, n211, n212, n214, n215, n216, n217, n218, n220, n224, n225, n226, n230, n231, n232, n234, n235, n236, n239, n243, n244, n246, n248, n254, n255, n256, n257, n259, n267, n268, n270, n291, n340, n341, n343, n344, n348, n349, n351, n352, n354, n392, n393, n394, n395, n396, n509, n511, n512, n516, n517, n520, n523, n618, n620, n623, n624, n626, n627, n629, n657, n660, n663, n665, n666, n667, n978, n979, n980, n981, n982, n1011, n1018, n1019, n1021, n1024, n1027
[Reiner D]] Mac-d (Muscle ACtivation-Defective)
[C.elegansII] e1500sd : adults paralysed, Egl; slightly long;abnormal muscle; contract and relax when prodded (`rubber-band' phenotype). Muscle activation defective (flaccid, long).ES3 ME0. Poor mating in e1500/+ males. Neomorphic allele, gf. OA1 (gf): n200(resembles e1500 but less severe phenotype).Both gf alleles suppressed by sup-9, sup-10,sup-11, sup-18. Also lf alleles: n392 (no phenotype alone but fails to complement e1500), n393 etc. Intragenic revertants of e1500 all have similar WT lf phenotype: e1500n234amb, des, e1500n200spo, e1500n243gri, e1500n1415::Tc1, etc. OA>30 (ird). Cloned: 2.2 kb transcripts (slightly different 5'), encoding 700 and 705 aa predicted novel proteins with multiple (5-10) possible TM domains. [Greenwald and Horvitz 1980; Levin and Horvitz 1992;MT]
Strain (31)
RNASeq_FPKM (74)
GO_annotation (16)
OrthologWBGene00054840Caenorhabditis remaneiFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00031294Caenorhabditis briggsaeFrom_analysisOrthoMCL
OMA
Inparanoid_8
WormBase-Compara
WBGene00134386Caenorhabditis japonicaFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00192027Caenorhabditis brenneriFrom_analysisTreeFam
Inparanoid_8
WormBase-Compara
WBGene00110862Pristionchus pacificusFrom_analysisInparanoid_8
WBGene00232469Brugia malayiFrom_analysisWormBase-Compara
CBOVI.g6684Caenorhabditis bovisFrom_analysisWormBase-Compara
CSP21.g15155Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP26.g3790Caenorhabditis zanzibariFrom_analysisWormBase-Compara
CSP28.g71Caenorhabditis panamensisFrom_analysisWormBase-Compara
CSP29.g962Caenorhabditis beceiFrom_analysisWormBase-Compara
CSP31.g25680Caenorhabditis uteleiaFrom_analysisWormBase-Compara
CSP32.g1286Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP38.g18834Caenorhabditis quiockensisFrom_analysisWormBase-Compara
CSP39.g1730Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP40.g8154Caenorhabditis tribulationisFrom_analysisWormBase-Compara
Cang_2012_03_13_00243.g7744Caenorhabditis angariaFrom_analysisWormBase-Compara
Cni-unc-93Caenorhabditis nigoniFrom_analysisWormBase-Compara
Cnig_chr_III.g10500Caenorhabditis nigoniFrom_analysisWormBase-Compara
Csp11.Scaffold629.g9500Caenorhabditis tropicalisFrom_analysisWormBase-Compara
Csp5_scaffold_00081.g3655Caenorhabditis sinicaFrom_analysisWormBase-Compara
FL83_10288Caenorhabditis latensFrom_analysisWormBase-Compara
GCK72_009704Caenorhabditis remaneiFrom_analysisWormBase-Compara
OTIPU.nOt.2.0.1.g02194Oscheius tipulaeFrom_analysisWormBase-Compara
Pan_g15210Panagrellus redivivusFrom_analysisWormBase-Compara
Sp34_30220500Caenorhabditis inopinataFrom_analysisWormBase-Compara
chrIII_pilon.g7286Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00248237Onchocerca volvulusFrom_analysisWormBase-Compara
WBGene00273770Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00266883Strongyloides rattiFrom_analysisWormBase-Compara
WBGene00286260Trichuris murisFrom_analysisWormBase-Compara
WBGene00300193Trichuris murisFrom_analysisWormBase-Compara
FB:FBgn0027556Drosophila melanogasterFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
FB:FBgn0033289Drosophila melanogasterFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
ZFIN:ZDB-GENE-041014-304Danio rerioFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
HGNC:12570Homo sapiensFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
MGI:1933250Mus musculusFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
MGI:3712668Mus musculusFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
RGD:1583290Rattus norvegicusFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
Structured_descriptionConcise_descriptionunc-93 encodes a novel transmembrane protein that affects muscle contraction and egg laying; UNC-93 is predicted to be a component of a multi-protein complex containing the SUP-9 two-pore potassium channel and the SUP-10 transmembrane protein; an UNC-93::GFP fusion protein is expressed in body wall muscle membranes and dense bodies as well as in the vulval and intestinal muscles; neuronal UNC-93::GFP expression is found in the four SIA neurons that originate in the head, receive some synapses in the nerve ring, and extend posteriorly directed processes; in muscle cells, UNC-93::GFP colocalizes with SUP-9 to dense bodies and membranes.Paper_evidenceWBPaper00000486
WBPaper00000564
WBPaper00001525
WBPaper00001800
WBPaper00006135
Curator_confirmedWBPerson1843
WBPerson324
Date_last_updated26 Jun 2008 00:00:00
Automated_descriptionEnables potassium channel regulator activity. Involved in regulation of muscle contraction and regulation of potassium ion transport. Located in plasma membrane and striated muscle dense body. Expressed in SIA; body wall musculature; and non-striated muscle. Is an ortholog of human UNC93A (unc-93 homolog A).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSC46F11.1a
C46F11.1b
Corresponding_CDS_historyC46F11.1:wp80
C46F11.1:wp138
C46F11.1:wp140
Corresponding_transcriptC46F11.1a.1
C46F11.1b.1
Other_sequenceFE914682.1
FE913923.1
Dviv_isotig29800
ASC31488_1
JI167429.1
Associated_featureWBsf991851
WBsf991852
WBsf991853
WBsf991854
WBsf224634
Experimental_infoRNAi_result (12)
Expr_patternExpr2773
Expr2775
Expr1019911
Expr1032886
Expr1146588
Expr2017919
Expr2036055
Drives_construct (19)
Construct_product (23)
Microarray_results (23)
Expression_cluster (85)
Interaction (54)
Map_infoMapIIIPosition-5.0882Error0.020586
Well_ordered
PositiveInside_rearrnDf6
nDf7
nDf8
nDf10
nDf11
nDf12
nDf13
nDf14
nDf15
Positive_cloneC46F11Inferred_automaticallyFrom sequence, transcript, pseudogene data
MT#JL932
Mapping_data2_point402
403
6037
6039
6040
Multi_point (46)
Pos_neg_data (11)
Landmark_gene
ReferenceWBPaper00000486
WBPaper00000564
WBPaper00000608
WBPaper00000712
WBPaper00000761
WBPaper00000785
WBPaper00000797
WBPaper00000898
WBPaper00000977
WBPaper00001009
WBPaper00001126
WBPaper00001230
WBPaper00001525
WBPaper00001686
WBPaper00001709
WBPaper00001738
WBPaper00001800
WBPaper00001869
WBPaper00002006
WBPaper00002305
WBPaper00002800
WBPaper00002898
WBPaper00004202
WBPaper00004406
WBPaper00004588
WBPaper00004982
WBPaper00005340
WBPaper00005423
WBPaper00005597
WBPaper00005736
WBPaper00006135
WBPaper00010337
WBPaper00010469
WBPaper00010703
WBPaper00010988
WBPaper00011218
WBPaper00011224
WBPaper00012415
WBPaper00013746
WBPaper00013792
WBPaper00013806
WBPaper00013833
WBPaper00013953
WBPaper00013985
WBPaper00014051
WBPaper00014077
WBPaper00014276
WBPaper00014306
WBPaper00014419
WBPaper00014525
WBPaper00014558
WBPaper00014561
WBPaper00014950
WBPaper00014989
WBPaper00015071
WBPaper00015174
WBPaper00015243
WBPaper00015440
WBPaper00015575
WBPaper00016026
WBPaper00016043
WBPaper00016177
WBPaper00016200
WBPaper00016201
WBPaper00016303
WBPaper00016312
WBPaper00017200
WBPaper00017528
WBPaper00018216
WBPaper00018281
WBPaper00018325
WBPaper00018824
WBPaper00019245
WBPaper00019669
WBPaper00020859
WBPaper00021105
WBPaper00022012
WBPaper00022108
WBPaper00022235
WBPaper00022237
WBPaper00022372
WBPaper00022486
WBPaper00022730
WBPaper00022931
WBPaper00023094
WBPaper00023098
WBPaper00023278
WBPaper00023523
WBPaper00025371
WBPaper00025430
WBPaper00026459
WBPaper00026595
WBPaper00027237
WBPaper00027249
WBPaper00027255
WBPaper00027851
WBPaper00027869
WBPaper00029020
WBPaper00030148
WBPaper00030492
WBPaper00030712
WBPaper00031213
WBPaper00032784
WBPaper00032907
WBPaper00034880
WBPaper00035439
WBPaper00038491
WBPaper00040284
WBPaper00040388
WBPaper00041328
WBPaper00044940
WBPaper00055090
WBPaper00060930
WBPaper00064400
MethodGene