| WBGene00006812 | SMap | S_parent | Sequence | F25C8 |
|---|
| Identity | Version | 2 |
| | Name | CGC_name | unc-80 | Person_evidence | WBPerson261 |
| | | Sequence_name | F25C8.3 |
| | | Molecular_name (15) |
| | | Other_name | CELE_F25C8.3 | Accession_evidence | NDB | BX284605 |
| | | Public_name | unc-80 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | | | 2 | 13 Nov 2007 10:02:04 | WBPerson2970 | Event | Acquires_merge | WBGene00009105 |
| | | Acquires_merge | WBGene00009105 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | unc |
| | Reference_allele | WBVar00143879 |
| | Allele (316) |
| | Legacy_information | e1272 : slightly sluggish tends to pause good movement. ES1 ME3. NA2 (e1069). |
| | | See also e1069, e1272 |
| | | [C.elegansII] e1272 : slightly sluggish, tends to pause ("fainter"), good movement; hypersensitive to volatile anaesthetics.ES1 ME3. OA2: e1069, m513. [Sedensky and Meneely 1987; Morgan et al. 1991; CW] |
| | Strain | WBStrain00032777 |
| | | WBStrain00040621 |
| | | WBStrain00004238 |
| | | WBStrain00004286 |
| | RNASeq_FPKM (74) |
| | GO_annotation (15) |
| | Ortholog (35) |
| | Structured_description | Concise_description | unc-80 encodes a novel protein, conserved amongst C. elegans, Drosophila, and vertebrates; unc-79 functions in a pathway with unc-77 and nca-2, which encode alpha-1 subunits of voltage-insensitive cation leak channels, to regulate presynaptic activation and thus, locomotion and the response to specific volatile anesthetics; co-expression of UNC-77 and UNC-80 in HEK293T cells results in increased UNC-77 channel activity, in a manner consistent with UNC-77 and UNC-80 functioning as an ion leak channel; an unc-80::gfp reporter fusion is expressed in many sensory and all motoneurons; in the nerve ring and in dorsal and ventral nerve cords, UNC-80 localizes to specific axonal regions, but not to synapses; UNC-80, UNC-77, and UNC-79, an additional novel protein believed to act in the same pathway, reciprocally regulate their expression levels in neurons. | Paper_evidence | WBPaper00001281 |
| | | | | | WBPaper00031000 |
| | | | | | WBPaper00031592 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 22 Jun 2010 00:00:00 |
| | | Automated_description | Enables monoatomic cation channel activity. Involved in several processes, including monoatomic cation homeostasis; positive regulation of locomotion; and response to anesthetic. Located in axon. Part of cation channel complex. Expressed in excretory canal; hermaphrodite distal tip cell; nervous system; and non-striated muscle. Is an ortholog of human UNC80 (unc-80 homolog, NALCN channel complex subunit). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | EFO:MONDO:0014176 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:26582) |
| Molecular_info | Corresponding_CDS | F25C8.3a |
| | | F25C8.3b |
| | | F25C8.3c |
| | | F25C8.3d |
| | | F25C8.3e |
| | Corresponding_CDS_history | F25C8.3:wp87 |
| | | F25C8.3:wp109 |
| | | F25C8.3a:wp182 |
| | Corresponding_transcript | F25C8.3a.1 |
| | | F25C8.3b.1 |
| | | F25C8.3c.1 |
| | | F25C8.3d.1 |
| | | F25C8.3e.1 |
| | Other_sequence (25) |
| | Associated_feature | WBsf647771 |
| | | WBsf662284 |
| | | WBsf662285 |
| | | WBsf662286 |
| | | WBsf1003660 |
| | | WBsf1003661 |
| | | WBsf1003662 |
| | | WBsf1022024 |
| | | WBsf1022025 |
| | | WBsf1022026 |
| Experimental_info | RNAi_result (12) |
| | Expr_pattern | Expr4994 |
| | | Expr8059 |
| | | Expr8061 |
| | | Expr16166 |
| | | Expr1026757 |
| | | Expr1032878 |
| | | Expr1149400 |
| | | Expr2017910 |
| | | Expr2036046 |
| | Drives_construct | WBCnstr00000610 |
| | | WBCnstr00001622 |
| | | WBCnstr00013085 |
| | | WBCnstr00042790 |
| | Construct_product | WBCnstr00000610 |
| | Microarray_results (26) |
| | Expression_cluster | WBPaper00024970:GABAergic_neuron_specific |
| | | WBPaper00031040:TGF-beta_adult_upregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037055:DAF-16_binding_DNA |
| | | WBPaper00037950:A-class-motor-neurons_larva_enriched |
| | | WBPaper00037950:all-neurons_embryo_enriched |
| | | WBPaper00037950:AVA-neuron_embryo_enriched |
| | | WBPaper00037950:AVE-neuron_embryo_enriched |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:dopaminergic-neurons_embryo_enriched |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_embryo_enriched |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00042215:wdr-23(tm1817)_upregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00046795:starvation_upregulated |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:cco-1(RNAi)_downregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi) |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_100-cell-embryo |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050496:unc-39(hp701)_regulated |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051404:alg-2(ok304)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053295:lin-22(icb38)_upregulated |
| | | WBPaper00053295:lin-22(ot267)_upregulated |
| | | WBPaper00053295:lin-22(ot269)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053814:15C_downregulated_OP50 |
| | | WBPaper00054493:hpl-2(tm1489)_upregulated |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055103:thoc-5(wy822)_upregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_downregulated |
| | | WBPaper00055354:Rifampicin-Psora_upregulated |
| | | WBPaper00055565:AVK_enriched |
| | | WBPaper00055626:pry-1(mu38)_downregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_upregulated_N2 |
| | | WBPaper00056284:ints-5(RNAi)_upregulated |
| | | WBPaper00056443:DietaryRestriction_downregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056809:smn-1(ok355)_upregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00057288:iff-1(RNAi)_upregulated_transcript |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058711:wdr-5(ok1417)_upregulated |
| | | WBPaper00058942:henn-1(pk2295)_upregulated |
| | | WBPaper00058969:RIS_enriched |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059566:wdr-23(mac32)_upregulated |
| | | WBPaper00059567:olrn-1(ums9)_regulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060683:hlh-11(ko1)_upregulated |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061203:let-418(n3536)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061340:ALA |
| | | WBPaper00061340:AVA |
| | | WBPaper00061340:AVB |
| | | WBPaper00061340:AVE |
| | | WBPaper00061340:AVG |
| | | WBPaper00061340:AVH |
| | | WBPaper00061340:AVK |
| | | WBPaper00061340:AVL |
| | | WBPaper00061340:DA |
| | | WBPaper00061340:DA_DB |
| | | WBPaper00061340:DB |
| | | WBPaper00061340:DD |
| | | WBPaper00061340:DVA |
| | | WBPaper00061340:DVC |
| | | WBPaper00061340:hmc |
| | | WBPaper00061340:OLL |
| | | WBPaper00061340:OLQ |
| | | WBPaper00061340:PVR |
| | | WBPaper00061340:RIB |
| | | WBPaper00061340:RIC |
| | | WBPaper00061340:RIH |
| | | WBPaper00061340:RIM |
| | | WBPaper00061340:RIS |
| | | WBPaper00061340:RIV |
| | | WBPaper00061340:SMD |
| | | WBPaper00061340:Y |
| | | WBPaper00061341:28C_24h_upregulated |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061439:unc-30(ok613)_downregulated |
| | | WBPaper00061466:nath-10(icb99)_downregulated |
| | | WBPaper00061466:nath-10(icb102)_downregulated |
| | | WBPaper00061479:mep-1(ne4629)_upregulated |
| | | WBPaper00061527:sol-1-jnk-1_18695 |
| | | WBPaper00061651:AS_enriched |
| | | WBPaper00061651:AVA_enriched |
| | | WBPaper00061651:AVL_enriched |
| | | WBPaper00061651:DA9_enriched |
| | | WBPaper00061651:DA_enriched |
| | | WBPaper00061651:DB01_enriched |
| | | WBPaper00061651:DB_enriched |
| | | WBPaper00061651:I1_enriched |
| | | WBPaper00061651:LUA_enriched |
| | | WBPaper00061651:PDA_enriched |
| | | WBPaper00061651:PDB_enriched |
| | | WBPaper00061651:PHC_enriched |
| | | WBPaper00061651:RIB_enriched |
| | | WBPaper00061651:RMD_DV_enriched |
| | | WBPaper00061651:SAB_enriched |
| | | WBPaper00061651:VA12_enriched |
| | | WBPaper00061651:VA_enriched |
| | | WBPaper00061651:VB_enriched |
| | | WBPaper00061753:csr-1(tor159)_downregulated_20C |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062193:skn-1(RNAi)_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064005:starvation_upregulated_aptf-1(gk794)_mRNA |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064156:lbp-3(overexpress)_upregulated |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs |
| | | WBPaper00064532:pals-25(icb98)_upregulated |
| | | WBPaper00064721:fasn-1(g14)_downregulated_starved |
| | | WBPaper00064871:hypoxia_downregulated_F1 |
| | | WBPaper00064939:vit-5(RNAi)_upregulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065623:80 |
| | | WBPaper00065749:Heat-Shock_downregulated_N2 |
| | | WBPaper00065841:14_2 |
| | | WBPaper00065841:52_0 |
| | | WBPaper00065841:61_0 |
| | | WBPaper00065841:68_0 |
| | | WBPaper00065841:100_0 |
| | | WBPaper00065841:108_0 |
| | | WBPaper00065841:132_0 |
| | | WBPaper00065841:134_0 |
| | | WBPaper00065841:136_0 |
| | | WBPaper00065841:140_0 |
| | | WBPaper00066062:xrep-4(lax137)_upregulated |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | cgc4489_group_20 |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_upregulated |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Enriched_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00030839:Embryo_A_Class |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00030985:Enterococcus_faecalis_upregulated |
| | | WBPaper00030985:Photorhabdus_luminescens_upregulated |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:24hr_muscle_depleted |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_1 |
| | | WBPaper00032948:StarveUp1 |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00036286:Pattern_C |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040823:alg-1(gk214)_downregulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_24h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_3h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00042548:miRISC_enriched |
| | | WBPaper00045263:isp-1(qm150)_upregulated |
| | | WBPaper00047070:N2_starvation_upregulated |
| | | WBPaper00047070:xpa-1_UV_downregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc6390]:Cluster_A |
| | Interaction (41) |
| Map_info | Map | V | Position | 25.581 | Error | 0.021198 |
| | Positive | Positive_clone | F25C8 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 1568 |
| Reference (46) |
| Method | Gene |
