WormBase Tree Display for Gene: WBGene00006812

WBGene00006812 SMap: S_parent: Sequence: F25C8
  Identity: Version: 2
    Name: CGC_name: unc-80 Person_evidence: WBPerson261
      Sequence_name: F25C8.3
      Molecular_name (15)
      Other_name: CELE_F25C8.3 Accession_evidence: NDB BX284605
      Public_name: unc-80
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:43 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 13 Nov 2007 10:02:04 WBPerson2970 Event: Acquires_merge: WBGene00009105
      Acquires_merge: WBGene00009105
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Reference_allele: WBVar00143879
    Allele: WBVar00143720 Inferred_automatically: From strain object: CB1069
      WBVar00239133 Inferred_automatically: From strain object: XA3702
      WBVar00145324
      WBVar00145325
      WBVar00145321
      WBVar02147657
      WBVar02147655
      WBVar02147654
      WBVar02147656
      WBVar02150637
      WBVar01110289
      WBVar01756952
      WBVar00095024
      WBVar01110290
      WBVar00095025
      WBVar01756953
      WBVar01110291
      WBVar01756954
      WBVar01110292
      WBVar01110293
      WBVar00601023
      WBVar01110294
      WBVar01110295
      WBVar01110296
      WBVar01110297
      WBVar01110298
      WBVar01110299
      WBVar01110300
      WBVar01110301
      WBVar01110302
      WBVar01110303
      WBVar01110304
      WBVar01110305
      WBVar01110306
      WBVar01110307
      WBVar01110308
      WBVar00491423
      WBVar00491424
      WBVar01110309
      WBVar00491425
      WBVar01110310
      WBVar01110311
      WBVar00491426
      WBVar00491427
      WBVar01110312
      WBVar00229356
      WBVar00491428
      WBVar01110313
      WBVar01110314
      WBVar01498436
      WBVar00229360
      WBVar00491429
      WBVar01110315
      WBVar00491430
      WBVar01110316
      WBVar00491431
      WBVar01110317
      WBVar00491432
      WBVar00491433
      WBVar01110318
      WBVar00491434
      WBVar00093867
      WBVar01110319
      WBVar02026534
      WBVar01110320
      WBVar02026535
      WBVar00491435
      WBVar02026536
      WBVar00491436
      WBVar01110321
      WBVar02026537
      WBVar00491437
      WBVar01110322
      WBVar01110323
      WBVar02026538
      WBVar00491438
      WBVar02026539
      WBVar01110324
      WBVar00491439
      WBVar01499184
      WBVar02138525
      WBVar02026540
      WBVar01110325
      WBVar00491440
      WBVar01110326
      WBVar00491441
      WBVar02026541
      WBVar00491442
      WBVar01110327
      WBVar00491443
      WBVar01110328
      WBVar01110329
      WBVar00491444
      WBVar01110330
      WBVar00491445
      WBVar01110331
      WBVar00491446
      WBVar01829929
      WBVar00491447
      WBVar01110332
      WBVar01829930
      WBVar01110333
      WBVar01829931
      WBVar00491448
      WBVar01110334
      WBVar00491449
      WBVar00491450
      WBVar01110335
      WBVar01978836
      WBVar01110336
      WBVar00491451
      WBVar02044299
      WBVar01941362
      WBVar01110337
      WBVar00491452
      WBVar00491453
      WBVar01110338
      WBVar01941363
      WBVar00491454
      WBVar01110339
      WBVar00491455
      WBVar01110340
      WBVar01678825
      WBVar00491456
      WBVar01678826
      WBVar01110341
      WBVar00491457
      WBVar01678827
      WBVar01110342
      WBVar00491458
      WBVar01678828
      WBVar00491459
      WBVar01878003
      WBVar00491460
      WBVar00491461
      WBVar01878004
      WBVar00491462
      WBVar01878005
      WBVar01878006
      WBVar00491463
      WBVar00491464
      WBVar00491465
      WBVar00603331
      WBVar00603332
      WBVar00603333
      WBVar00603334
      WBVar00074017
      WBVar00074018
      WBVar00074019
      WBVar00143879
      WBVar00074020
      WBVar00074021
      WBVar00074022
      WBVar01110190
      WBVar00313463
      WBVar00074023
      WBVar01110191
      WBVar00074024
      WBVar01110192
      WBVar00074025
      WBVar00074026
      WBVar01110193
      WBVar01600071
      WBVar00074027
      WBVar01600072
      WBVar01110194
      WBVar00074028
      WBVar01110195
      WBVar01600073
      WBVar00074029
      WBVar01600074
      WBVar01110196
      WBVar01600075
      WBVar00074030
      WBVar01110197
      WBVar01110198
      WBVar01600076
      WBVar01110199
      WBVar01110200
      WBVar01110201
      WBVar01110202
      WBVar01786793
      WBVar01110203
      WBVar01110204
      WBVar01110205
      WBVar01110206
      WBVar01110207
      WBVar01110208
      WBVar01110209
      WBVar01110210
      WBVar01110211
      WBVar01110212
      WBVar01110213
      WBVar01110214
      WBVar01110215
      WBVar02147969
      WBVar01110216
      WBVar01110217
      WBVar01110218
      WBVar01499446
      WBVar01110219
      WBVar01110220
      WBVar01926696
      WBVar01110221
      WBVar01500000
      WBVar01110222
      WBVar01110223
      WBVar01110224
      WBVar01110225
      WBVar01110226
      WBVar01526427
      WBVar01110227
      WBVar01526428
      WBVar01110228
      WBVar01526429
      WBVar01526430
      WBVar01110229
      WBVar01526431
      WBVar01110230
      WBVar01110231
      WBVar01110232
      WBVar01110233
      WBVar01110234
      WBVar01110235
      WBVar01110236
      WBVar01110237
      WBVar01110238
      WBVar01498729
      WBVar01110239
      WBVar01110240
      WBVar01110241
      WBVar01110242
      WBVar01110243
      WBVar01498549
      WBVar01110244
      WBVar01110245
      WBVar01110246
      WBVar01110247
      WBVar01110248
      WBVar01110249
      WBVar01110250
      WBVar01110251
      WBVar01110252
      WBVar01110253
      WBVar01110254
      WBVar01822243
      WBVar01110255
      WBVar01499299
      WBVar01110256
      WBVar01110257
      WBVar01110258
      WBVar01110259
      WBVar01110260
      WBVar01110261
      WBVar01110262
      WBVar01110263
      WBVar01110264
      WBVar01110265
      WBVar01110266
      WBVar01110267
      WBVar01756930
      WBVar01486061
      WBVar02074500
      WBVar02074501
      WBVar01110268
      WBVar01756931
      WBVar01110269
      WBVar01756932
      WBVar01110270
      WBVar01756933
      WBVar01110271
      WBVar01756934
      WBVar01110272
      WBVar01756935
      WBVar01110273
      WBVar01544418
      WBVar01756936
      WBVar01756937
      WBVar01110274
      WBVar01544419
      WBVar01756938
      WBVar01544420
      WBVar01110275
      WBVar01914168
      WBVar01110276
      WBVar01756939
      WBVar01544421
      WBVar01756940
      WBVar01914169
      WBVar01110277
      WBVar01756941
      WBVar01110278
      WBVar01756942
      WBVar01110279
      WBVar01110280
      WBVar01756943
      WBVar01756944
      WBVar01110281
      WBVar01756945
      WBVar01110282
      WBVar01756946
      WBVar01110283
      WBVar01894562
      WBVar00095019
      WBVar01756947
      WBVar01110284
      WBVar01110285
      WBVar01756948
      WBVar01756949
      WBVar01110286
      WBVar00095022
      WBVar01756950
      WBVar01110287
      WBVar00095023
      WBVar01110288
      WBVar01756951
    Legacy_information: e1272 : slightly sluggish tends to pause good movement. ES1 ME3. NA2 (e1069).
      See also e1069, e1272
      [C.elegansII] e1272 : slightly sluggish, tends to pause ("fainter"), good movement; hypersensitive to volatile anaesthetics.ES1 ME3. OA2: e1069, m513. [Sedensky and Meneely 1987; Morgan et al. 1991; CW]
    Strain: WBStrain00032777
      WBStrain00040621
      WBStrain00004238
      WBStrain00004286
    RNASeq_FPKM (74)
    GO_annotation (15)
    Ortholog (35)
    Structured_description: Concise_description: unc-80 encodes a novel protein, conserved amongst C. elegans, Drosophila, and vertebrates; unc-79 functions in a pathway with unc-77 and nca-2, which encode alpha-1 subunits of voltage-insensitive cation leak channels, to regulate presynaptic activation and thus, locomotion and the response to specific volatile anesthetics; co-expression of UNC-77 and UNC-80 in HEK293T cells results in increased UNC-77 channel activity, in a manner consistent with UNC-77 and UNC-80 functioning as an ion leak channel; an unc-80::gfp reporter fusion is expressed in many sensory and all motoneurons; in the nerve ring and in dorsal and ventral nerve cords, UNC-80 localizes to specific axonal regions, but not to synapses; UNC-80, UNC-77, and UNC-79, an additional novel protein believed to act in the same pathway, reciprocally regulate their expression levels in neurons. Paper_evidence: WBPaper00001281
            WBPaper00031000
            WBPaper00031592
          Curator_confirmed: WBPerson1843
          Date_last_updated: 22 Jun 2010 00:00:00
      Automated_description: Enables monoatomic cation channel activity. Involved in several processes, including monoatomic cation homeostasis; positive regulation of locomotion; and response to anesthetic. Located in axon. Part of cation channel complex. Expressed in excretory canal; hermaphrodite distal tip cell; nervous system; and non-striated muscle. Is an ortholog of human UNC80 (unc-80 homolog, NALCN channel complex subunit). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: EFO:MONDO:0014176 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:26582)
  Molecular_info: Corresponding_CDS: F25C8.3a
      F25C8.3b
      F25C8.3c
      F25C8.3d
      F25C8.3e
    Corresponding_CDS_history: F25C8.3:wp87
      F25C8.3:wp109
      F25C8.3a:wp182
    Corresponding_transcript: F25C8.3a.1
      F25C8.3b.1
      F25C8.3c.1
      F25C8.3d.1
      F25C8.3e.1
    Other_sequence (25)
    Associated_feature: WBsf647771
      WBsf662284
      WBsf662285
      WBsf662286
      WBsf1003660
      WBsf1003661
      WBsf1003662
      WBsf1022024
      WBsf1022025
      WBsf1022026
  Experimental_info: RNAi_result (12)
    Expr_pattern: Expr4994
      Expr8059
      Expr8061
      Expr16166
      Expr1026757
      Expr1032878
      Expr1149400
      Expr2017910
      Expr2036046
    Drives_construct: WBCnstr00000610
      WBCnstr00001622
      WBCnstr00013085
      WBCnstr00042790
    Construct_product: WBCnstr00000610
    Microarray_results (26)
    Expression_cluster (205)
    Interaction (41)
  Map_info: Map: V Position: 25.581 Error: 0.021198
    Positive: Positive_clone: F25C8 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 1568
  Reference (46)
  Method: Gene