| WBGene00006802 | SMap | S_parent | Sequence | T07A5 |
|---|
| Identity | Version | 2 |
| | Name | CGC_name | unc-69 | Paper_evidence | WBPaper00027646 |
| | | | | Person_evidence | WBPerson261 |
| | | Sequence_name | T07A5.6 |
| | | Molecular_name | T07A5.6a |
| | | | T07A5.6a.1 |
| | | | CE23955 |
| | | | T07A5.6b |
| | | | CE38102 |
| | | | T07A5.6c |
| | | | CE41450 |
| | | | T07A5.6b.1 |
| | | | T07A5.6c.1 |
| | | Other_name | CELE_T07A5.6 | Accession_evidence | NDB | BX284603 |
| | | Public_name | unc-69 |
| | DB_info | Database | AceView | gene | 3L409 |
| | | | WormFlux | gene | WBGene00006802 |
| | | | NDB | locus_tag | CELE_T07A5.6 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00006802|UniProtKB=A7LPF8 |
| | | | | family | PTHR21614 |
| | | | NCBI | gene | 176444 |
| | | | RefSeq | protein | NM_001027582.4 |
| | | | | | NM_001027581.5 |
| | | | | | NM_001129245.5 |
| | | | TREEFAM | TREEFAM_ID | TF323340 |
| | | | TrEMBL | UniProtAcc | A7LPF8 |
| | | | | | Q9U377 |
| | | | | | G5EDQ5 |
| | | | UniProt_GCRP | UniProtAcc | A7LPF8 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | | | 2 | 30 Oct 2007 10:02:14 | WBPerson2970 | Event | Acquires_merge | WBGene00044098 |
| | | | | | | Name_change | Sequence_name | T07A5.6 |
| | | Acquires_merge | WBGene00044098 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | unc |
| | Reference_allele | WBVar00143321 |
| | Allele (18) |
| | Legacy_information | e587 : medium coiler inactive small; abnormalities in VD and DD commissures. ES3 ME0. NA2 (e602). |
| | | [C.elegansII] e587 : medium coiler, inactive, small; abnormalities in VD and DD commissures, longitudinal axon elongation. ES3 ME0. OA1: e602. Cloned: cosmid rescue (C46D2). [Brenner 1974; NG; SQ; WS] |
| | Strain (16) |
| | RNASeq_FPKM (74) |
| | GO_annotation | 00005135 |
| | | 00005136 |
| | | 00005137 |
| | | 00005138 |
| | | 00005139 |
| | | 00005140 |
| | | 00005141 |
| | | 00005142 |
| | | 00005143 |
| | Ortholog (36) |
| | Structured_description | Concise_description | unc-69 encodes, by alternative splicing, three isoforms of a small (102- to 176-residue) coiled-coil protein required for normal axonal extension, axonal guidance, neuronal fasciculation, and synaptic vesicle localization; UNC-69 is orthologous to human SCOCO, which can transgenically rescue the locomotion defect of strong unc-69 mutants; UNC-69 is expressed in embryos, the processes and growth cones of immature neurons, and in the cell bodies of many (perhaps all) mature neurons; UNC-69 acts cell-autonomously in at least touch neurons, and perhaps all neurons; since UNC-69 binds a 19-residue conserved coiled-coil domain of UNC-76, UNC-69 and UNC-76 colocalize to neuronal puncta, unc-69 mutants phenotypically resemble unc-76, and mutations of these genes have nonallelic noncomplementation, UNC-69 and UNC-76 are likely to function as a complex. | Paper_evidence | WBPaper00000031 |
| | | | | | WBPaper00001345 |
| | | | | | WBPaper00002837 |
| | | | | | WBPaper00027646 |
| | | | | | WBPaper00027651 |
| | | | | | WBPaper00031100 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 18 Oct 2007 00:00:00 |
| | | Automated_description | Involved in regulation of axon extension and regulation of synapse organization. Located in axon; neuronal cell body; and perinuclear region of cytoplasm. Expressed in CAN; HSN; ganglia; somatic nervous system; and touch receptor neurons. Is an ortholog of human SCOC (short coiled-coil protein). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | T07A5.6a |
| | | T07A5.6b |
| | | T07A5.6c |
| | Corresponding_transcript | T07A5.6a.1 |
| | | T07A5.6b.1 |
| | | T07A5.6c.1 |
| | Other_sequence (59) |
| | Associated_feature (12) |
| Experimental_info | RNAi_result | WBRNAi00035291 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00062360 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr4900 |
| | | Expr7838 |
| | | Expr1016022 |
| | | Expr1032870 |
| | | Expr1156304 |
| | | Expr2017899 |
| | | Expr2036035 |
| | Drives_construct | WBCnstr00001400 |
| | | WBCnstr00012320 |
| | | WBCnstr00012950 |
| | Construct_product | WBCnstr00001400 |
| | | WBCnstr00012320 |
| | | WBCnstr00012950 |
| | Microarray_results (25) |
| | Expression_cluster | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037950:A-class-motor-neurons_larva_enriched |
| | | WBPaper00037950:glr-1(+)-neurons_larva_enriched |
| | | WBPaper00040285:H2S_24hr_upregulated |
| | | WBPaper00044426:rotenone_24h_upregulated |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045571:germline-ablation_downregulated |
| | | WBPaper00045729:gld-2(RNAi)_downregulated |
| | | WBPaper00045774:clk-1_downregulated |
| | | WBPaper00045774:clk-1_downregulated_CoQ10_independent |
| | | WBPaper00045974:NSM_enriched_totalRNA_RNAseq |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049498:npr-1(ur89)_regulated_3 |
| | | WBPaper00049545:jmjd-3.1(+)_downregulated |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00050182:lmn-1(L535P)_downregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053289:DREAM-target |
| | | WBPaper00053302:zidovudine_24h_regulated |
| | | WBPaper00055565:AVK_enriched |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056165:MINA-1_interacting_mRNA |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00057288:Cold_downregulated_transcript |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060100:SiNP_upregulated_mRNA |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061340:AVA |
| | | WBPaper00061340:AVB |
| | | WBPaper00061340:AVJ |
| | | WBPaper00061340:DA |
| | | WBPaper00061340:DB |
| | | WBPaper00061340:DD |
| | | WBPaper00061340:PVP |
| | | WBPaper00061340:RIB |
| | | WBPaper00061340:RID |
| | | WBPaper00061340:RIV |
| | | WBPaper00061340:SIA |
| | | WBPaper00061340:SIB |
| | | WBPaper00061340:SMB |
| | | WBPaper00061340:SMD |
| | | WBPaper00061439:unc-30(ok613)_upregulated |
| | | WBPaper00061527:Y32B12B.2-F28C1.1 |
| | | WBPaper00061651:AIZ_enriched |
| | | WBPaper00061651:AVJ_enriched |
| | | WBPaper00061651:DB01_enriched |
| | | WBPaper00061651:DB_enriched |
| | | WBPaper00061651:DVB_enriched |
| | | WBPaper00061651:DVC_enriched |
| | | WBPaper00061651:FLP_enriched |
| | | WBPaper00061651:HSN_enriched |
| | | WBPaper00061651:PDB_enriched |
| | | WBPaper00061651:PDE_enriched |
| | | WBPaper00061651:PVP_enriched |
| | | WBPaper00061651:PVR_enriched |
| | | WBPaper00061651:PVW_enriched |
| | | WBPaper00061651:SIA_enriched |
| | | WBPaper00061651:SIB_enriched |
| | | WBPaper00061651:SMB_enriched |
| | | WBPaper00061651:VA_enriched |
| | | WBPaper00061651:VB01_enriched |
| | | WBPaper00061651:VB02_enriched |
| | | WBPaper00061651:VB_enriched |
| | | WBPaper00061651:VC_4_5_enriched |
| | | WBPaper00061651:VC_enriched |
| | | WBPaper00061902:camt-1(ok515)_regulated_RMG |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065258:anchor-cell_enriched |
| | | WBPaper00065975:P-body_vs_oocyte_enriched |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | WBPaper00025032:cluster_8 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Enriched_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00030839:Embryo_A_Class |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00030839:Larval_A_Class |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00034757:down_by_oxidative_stress |
| | | WBPaper00035084:L1_enriched_AIN-2_IP |
| | | WBPaper00035084:L2_enriched_AIN-2_IP |
| | | WBPaper00035084:L3_enriched_AIN-2_IP |
| | | WBPaper00035084:L4_enriched_AIN-2_IP |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00037611:GLD-2-associated |
| | | WBPaper00037611:RNP-8-associated |
| | | WBPaper00037901:GLD-1_mRNA_targets |
| | | WBPaper00040985:AIN-2_L4_intestine |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | Interaction | WBInteraction000008990 |
| | | WBInteraction000522715 |
| | | WBInteraction000522716 |
| | | WBInteraction000547046 |
| Map_info | Map | III | Position | 2.3102 | Error | 0.00237 |
| | Well_ordered |
| | Positive | Inside_rearr | nDf40 |
| | | Positive_clone | T07A5 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Negative | Outside_rearr | tnDf2 |
| | Mapping_data | 2_point | 72 |
| | | | 578 |
| | | | 702 |
| | | | 5137 |
| | | | 6121 |
| | | Multi_point (75) |
| | | Pos_neg_data | 362 |
| | | | 669 |
| | | | 1597 |
| | | | 1620 |
| | | | 4768 |
| | | | 8638 |
| | | | 9454 |
| | | | 10533 |
| Reference (52) |
| Remark | on same cosmid as unc-50; genetic map data indicate unc-69 left of unc-50 JAH 01/01 |
| Method | Gene |
