WormBase Tree Display for Gene: WBGene00006792
expand all nodes | collapse all nodes | view schema
| WBGene00006792 | SMap | S_parent | Sequence | T06H11 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | unc-58 | Person_evidence | WBPerson261 | |||||
| Sequence_name | T06H11.1 | ||||||||
| Molecular_name (21) | |||||||||
| Other_name | twk-18 | CGC_data_submission | |||||||
| CELE_T06H11.1 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | unc-58 | ||||||||
| DB_info | Database | AceView | gene | XK722 | |||||
| WormQTL | gene | WBGene00006792 | |||||||
| WormFlux | gene | WBGene00006792 | |||||||
| NDB | locus_tag | CELE_T06H11.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006792|UniProtKB=Q22271 | |||||||
| family | PTHR11003 | ||||||||
| NCBI | gene | 181224 | |||||||
| RefSeq | protein | NM_171758.5 | |||||||
| NM_001373460.3 | |||||||||
| NM_001373459.2 | |||||||||
| NM_001373458.4 | |||||||||
| NM_001373457.2 | |||||||||
| NM_001373456.2 | |||||||||
| NM_171759.6 | |||||||||
| SwissProt | UniProtAcc | Q22271 | |||||||
| TrEMBL | UniProtAcc | A0A4V0IKI8 | |||||||
| A0A4V0IL39 | |||||||||
| A0A4V0IKM3 | |||||||||
| A0A4V0INP7 | |||||||||
| A0A4V0INX3 | |||||||||
| UniProt_GCRP | UniProtAcc | Q22271 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 20 May 2019 15:21:47 | WBPerson4025 | Event | Acquires_merge | WBGene00011553 | ||||
| 3 | 20 May 2019 15:21:47 | WBPerson4025 | Event | Acquires_merge | WBGene00011552 | ||||
| Acquires_merge | WBGene00011553 | ||||||||
| WBGene00011552 | |||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00143382 | ||||||||
| Allele (568) | |||||||||
| Legacy_information | e665dm : `shaker' : animals short rigidly paralysed with constant shaking of body; e665/+ phenotype similar but weaker animals slightly longer and less rigid. ES3 ME0. NA (dominant) 5 (e415 n495 (similar phenotype) e778 (weaker phenotype)). Dominant alleles revert intragenically e.g. e665e2112 : recessive weak Unc (probable null phenotype). | ||||||||
| See also e415, e665, e757, e778, e1320, e2112, n272, n276, n278, n284, n286, n288, n495, n1273 | |||||||||
| [Reiner D]] Mac-h (Hyper-ACtivate Muscle) | |||||||||
| [C.elegansII] e665dm : `shaker', animals short, rigidly paralysed with constant shaking of body; e665/+ phenotype similar but weaker, animals slightly longer and less rigid. Muscle hyperactivated, sticky pumping, short.ES3 ME0. OA4 (dominant): e415, n495 (similar), e778 (weaker phenotype), etc. Dominant alleles revert intragenically e.g. e665e2112 : recessive weak Unc (probable null phenotype). [Brenner 1974; Park and Horvitz 1986; JT] | |||||||||
| Strain | WBStrain00026762 | ||||||||
| WBStrain00026763 | |||||||||
| WBStrain00026792 | |||||||||
| WBStrain00027002 | |||||||||
| WBStrain00004431 | |||||||||
| WBStrain00004508 | |||||||||
| WBStrain00004193 | |||||||||
| WBStrain00006242 | |||||||||
| WBStrain00055081 | |||||||||
| WBStrain00054759 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (18) | |||||||||
| Ortholog (35) | |||||||||
| Paralog (47) | |||||||||
| Structured_description | Concise_description | unc-58 encodes one of 44 C. elegans TWK (two-P domain K+) potassium channel subunits that contain two pore-forming domains and four transmembrane domains; unc-58 was originally defined by gain-of-function (gf) mutations that result in paralysis and a shortened (dumpy) body morphology due to hypercontraction of body wall muscle; unc-58 gf mutations also result in constitutive egg-laying; as loss of UNC-58 function via reversion or RNA-mediated interference (RNAi) results in either no abnormalities or only a weakly uncoordinated phenotype, UNC-58 likely functions redudantly with other TWK channels to regulate locomotion and egg-laying; UNC-58 is expressed in motor neurons and interneurons. | Paper_evidence | WBPaper00002305 | |||||
| WBPaper00002665 | |||||||||
| WBPaper00004644 | |||||||||
| WBPaper00005654 | |||||||||
| WBPaper00017138 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables outward rectifier potassium channel activity. Involved in several processes, including muscle contraction; parturition; and regulation of muscle contraction. Predicted to be located in membrane. Expressed in interneuron and motor neurons. Is an ortholog of human KCNK17 (potassium two pore domain channel subfamily K member 17) and KCNK5 (potassium two pore domain channel subfamily K member 5). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | T06H11.1a | |||||||
| T06H11.1b | |||||||||
| T06H11.1c | |||||||||
| T06H11.1d | |||||||||
| T06H11.1e | |||||||||
| T06H11.1f | |||||||||
| T06H11.1g | |||||||||
| Corresponding_CDS_history | T06H11.1:wp83 | ||||||||
| Corresponding_transcript | T06H11.1a.1 | ||||||||
| T06H11.1b.1 | |||||||||
| T06H11.1c.1 | |||||||||
| T06H11.1d.1 | |||||||||
| T06H11.1e.1 | |||||||||
| T06H11.1f.1 | |||||||||
| T06H11.1g.1 | |||||||||
| Other_sequence (29) | |||||||||
| Associated_feature (17) | |||||||||
| Experimental_info | RNAi_result (16) | ||||||||
| Expr_pattern | Expr2448 | ||||||||
| Expr1020117 | |||||||||
| Expr1021035 | |||||||||
| Expr1028695 | |||||||||
| Expr1032862 | |||||||||
| Expr1156295 | |||||||||
| Expr1156296 | |||||||||
| Expr1156298 | |||||||||
| Expr2017890 | |||||||||
| Expr2036026 | |||||||||
| Drives_construct | WBCnstr00010838 | ||||||||
| WBCnstr00030566 | |||||||||
| WBCnstr00030567 | |||||||||
| WBCnstr00034146 | |||||||||
| Construct_product | WBCnstr00010838 | ||||||||
| WBCnstr00030566 | |||||||||
| WBCnstr00030567 | |||||||||
| WBCnstr00034146 | |||||||||
| Microarray_results (51) | |||||||||
| Expression_cluster (171) | |||||||||
| Interaction | WBInteraction000028423 | ||||||||
| WBInteraction000136892 | |||||||||
| WBInteraction000165840 | |||||||||
| WBInteraction000200024 | |||||||||
| WBInteraction000243038 | |||||||||
| WBInteraction000331659 | |||||||||
| WBInteraction000418934 | |||||||||
| WBInteraction000430959 | |||||||||
| WBInteraction000456312 | |||||||||
| WBInteraction000585544 | |||||||||
| Map_info | Map | X | Position | 1.75032 | Error | 0.007954 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | stDp2 | |||||||
| nDf19 | |||||||||
| Positive_clone | T06H11 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| Mapping_data | 2_point (15) | ||||||||
| Multi_point | 442 | ||||||||
| 551 | |||||||||
| 651 | |||||||||
| 791 | |||||||||
| 792 | |||||||||
| 1343 | |||||||||
| 2260 | |||||||||
| 2454 | |||||||||
| 4314 | |||||||||
| 4494 | |||||||||
| Pos_neg_data | 272 | ||||||||
| 497 | |||||||||
| 942 | |||||||||
| 656 | |||||||||
| 661 | |||||||||
| Reference (43) | |||||||||
| Remark | The other-name twk-18 is different from the CGC-approved main name twk-18 (C24A3.6) | CGC_data_submission | |||||||
| Method | Gene |
