WormBase Tree Display for Gene: WBGene00006792
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WBGene00006792 | SMap | S_parent | Sequence | T06H11 | |||
---|---|---|---|---|---|---|---|
Identity | Version | 3 | |||||
Name | CGC_name | unc-58 | Person_evidence | WBPerson261 | |||
Sequence_name | T06H11.1 | ||||||
Molecular_name (21) | |||||||
Other_name | twk-18 | CGC_data_submission | |||||
CELE_T06H11.1 | Accession_evidence | NDB | BX284606 | ||||
Public_name | unc-58 | ||||||
DB_info | Database | AceView | gene | XK722 | |||
WormQTL | gene | WBGene00006792 | |||||
WormFlux | gene | WBGene00006792 | |||||
NDB | locus_tag | CELE_T06H11.1 | |||||
Panther | gene | CAEEL|WormBase=WBGene00006792|UniProtKB=Q22271 | |||||
family | PTHR11003 | ||||||
NCBI | gene | 181224 | |||||
RefSeq | protein | NM_171758.5 | |||||
NM_001373460.3 | |||||||
NM_001373459.2 | |||||||
NM_001373458.4 | |||||||
NM_001373457.2 | |||||||
NM_001373456.2 | |||||||
NM_171759.6 | |||||||
SwissProt | UniProtAcc | Q22271 | |||||
TrEMBL | UniProtAcc | A0A4V0IKI8 | |||||
A0A4V0IL39 | |||||||
A0A4V0IKM3 | |||||||
A0A4V0INP7 | |||||||
A0A4V0INX3 | |||||||
UniProt_GCRP | UniProtAcc | Q22271 | |||||
Species | Caenorhabditis elegans | ||||||
History (2) | |||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | unc | ||||||
Reference_allele | WBVar00143382 | ||||||
Allele (568) | |||||||
Legacy_information | e665dm : `shaker' : animals short rigidly paralysed with constant shaking of body; e665/+ phenotype similar but weaker animals slightly longer and less rigid. ES3 ME0. NA (dominant) 5 (e415 n495 (similar phenotype) e778 (weaker phenotype)). Dominant alleles revert intragenically e.g. e665e2112 : recessive weak Unc (probable null phenotype). | ||||||
See also e415, e665, e757, e778, e1320, e2112, n272, n276, n278, n284, n286, n288, n495, n1273 | |||||||
[Reiner D]] Mac-h (Hyper-ACtivate Muscle) | |||||||
[C.elegansII] e665dm : `shaker', animals short, rigidly paralysed with constant shaking of body; e665/+ phenotype similar but weaker, animals slightly longer and less rigid. Muscle hyperactivated, sticky pumping, short.ES3 ME0. OA4 (dominant): e415, n495 (similar), e778 (weaker phenotype), etc. Dominant alleles revert intragenically e.g. e665e2112 : recessive weak Unc (probable null phenotype). [Brenner 1974; Park and Horvitz 1986; JT] | |||||||
Strain | WBStrain00026762 | ||||||
WBStrain00026763 | |||||||
WBStrain00026792 | |||||||
WBStrain00027002 | |||||||
WBStrain00004431 | |||||||
WBStrain00004508 | |||||||
WBStrain00004193 | |||||||
WBStrain00006242 | |||||||
WBStrain00055081 | |||||||
WBStrain00054759 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (18) | |||||||
Ortholog (35) | |||||||
Paralog (47) | |||||||
Structured_description | Concise_description | unc-58 encodes one of 44 C. elegans TWK (two-P domain K+) potassium channel subunits that contain two pore-forming domains and four transmembrane domains; unc-58 was originally defined by gain-of-function (gf) mutations that result in paralysis and a shortened (dumpy) body morphology due to hypercontraction of body wall muscle; unc-58 gf mutations also result in constitutive egg-laying; as loss of UNC-58 function via reversion or RNA-mediated interference (RNAi) results in either no abnormalities or only a weakly uncoordinated phenotype, UNC-58 likely functions redudantly with other TWK channels to regulate locomotion and egg-laying; UNC-58 is expressed in motor neurons and interneurons. | Paper_evidence | WBPaper00002305 | |||
WBPaper00002665 | |||||||
WBPaper00004644 | |||||||
WBPaper00005654 | |||||||
WBPaper00017138 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||
Automated_description | Enables outward rectifier potassium channel activity. Involved in several processes, including muscle contraction; parturition; and regulation of muscle contraction. Predicted to be located in membrane. Expressed in interneuron and motor neurons. Is an ortholog of human KCNK17 (potassium two pore domain channel subfamily K member 17) and KCNK5 (potassium two pore domain channel subfamily K member 5). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | T06H11.1a | |||||
T06H11.1b | |||||||
T06H11.1c | |||||||
T06H11.1d | |||||||
T06H11.1e | |||||||
T06H11.1f | |||||||
T06H11.1g | |||||||
Corresponding_CDS_history | T06H11.1:wp83 | ||||||
Corresponding_transcript | T06H11.1a.1 | ||||||
T06H11.1b.1 | |||||||
T06H11.1c.1 | |||||||
T06H11.1d.1 | |||||||
T06H11.1e.1 | |||||||
T06H11.1f.1 | |||||||
T06H11.1g.1 | |||||||
Other_sequence (29) | |||||||
Associated_feature (17) | |||||||
Experimental_info | RNAi_result (16) | ||||||
Expr_pattern | Expr2448 | ||||||
Expr1020117 | |||||||
Expr1021035 | |||||||
Expr1028695 | |||||||
Expr1032862 | |||||||
Expr1156295 | |||||||
Expr1156296 | |||||||
Expr1156298 | |||||||
Expr2017890 | |||||||
Expr2036026 | |||||||
Drives_construct | WBCnstr00010838 | ||||||
WBCnstr00030566 | |||||||
WBCnstr00030567 | |||||||
WBCnstr00034146 | |||||||
Construct_product | WBCnstr00010838 | ||||||
WBCnstr00030566 | |||||||
WBCnstr00030567 | |||||||
WBCnstr00034146 | |||||||
Microarray_results (51) | |||||||
Expression_cluster (171) | |||||||
Interaction | WBInteraction000028423 | ||||||
WBInteraction000136892 | |||||||
WBInteraction000165840 | |||||||
WBInteraction000200024 | |||||||
WBInteraction000243038 | |||||||
WBInteraction000331659 | |||||||
WBInteraction000418934 | |||||||
WBInteraction000430959 | |||||||
WBInteraction000456312 | |||||||
WBInteraction000585544 | |||||||
Map_info | Map | X | Position | 1.75032 | Error | 0.007954 | |
Well_ordered | |||||||
Positive | Inside_rearr | stDp2 | |||||
nDf19 | |||||||
Positive_clone | T06H11 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||
Mapping_data | 2_point (15) | ||||||
Multi_point | 442 | ||||||
551 | |||||||
651 | |||||||
791 | |||||||
792 | |||||||
1343 | |||||||
2260 | |||||||
2454 | |||||||
4314 | |||||||
4494 | |||||||
Pos_neg_data | 272 | ||||||
497 | |||||||
942 | |||||||
656 | |||||||
661 | |||||||
Reference (43) | |||||||
Remark | The other-name twk-18 is different from the CGC-approved main name twk-18 (C24A3.6) | CGC_data_submission | |||||
Method | Gene |