WormBase Tree Display for Gene: WBGene00006786
expand all nodes | collapse all nodes | view schema
| WBGene00006786 | SMap | S_parent | Sequence | Y60A3A | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | unc-51 | Person_evidence | WBPerson261 | |||||
| Sequence_name | Y60A3A.1 | ||||||||
| Molecular_name | Y60A3A.1 | ||||||||
| Y60A3A.1.1 | |||||||||
| CE24516 | |||||||||
| Other_name | frs-2 | Accession_evidence | EMBL | AB096637 | |||||
| atg-1 | Person_evidence | WBPerson649 | |||||||
| CELE_Y60A3A.1 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | unc-51 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:42 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 29 Feb 2008 11:29:00 | WBPerson2970 | Name_change | Other_name | atg-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00143154 | ||||||||
| Allele (371) | |||||||||
| Legacy_information | e369 : paralysed dumpy tends to curl; Egl; dorsal extensions of DD and VD neurons grow in aberrant directions fail to connect to dorsal nerve cord; amphid phasmid PDE axons abnormal; suppressed by sup-4. ES3 ME0. NA6 (e389 e432 etc.). | ||||||||
| See also e432, e584, e1120, e1189, e1212 | |||||||||
| [C.elegansII] e369amb : paralysed dumpy tends to curl; Egl; dorsal extensions of DD and VD neurons grow in aberrant directions fail to connect to dorsal nerve cord; amphid, phasmid, PDE and other axons abnormal; multiple defects in axon elongation, fasciculation,etc. Abnormal axon ultrastructure: varicosities, cisternae, abnormal vesicles.ES3 ME0. OA>10: e389, e432, e584, e1212 etc. Cloned: 3.1 kb transcript, encodes predicted 856 aa protein with similarity to Ser/Thrkinases. unc-51: lacZ expressed in neurons. [Hedgecock et al. 1985; McIntire et al. 1992; Ogura et al. 1994; FK; FR] | |||||||||
| Strain (20) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (61) | |||||||||
| Ortholog (54) | |||||||||
| Paralog | WBGene00013694 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WBGene00013643 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| Structured_description | Concise_description | unc-51 encodes a serine/threonine protein kinase orthologous to Saccharomyces cerevisiae autophagy protein Atg1p and the vertebrate ULK proteins; unc-51 is required for axon outgrowth along the anterior-posterior axis and sex myoblast migration; in regulating axon outgrowth, UNC-51 functions together with the VAB-8 kinesin-like protein and UNC-14, both of which physically interact with, and are phosphorylated by, UNC-51, and with the UNC-5 Netrin receptor, whose subcellular localization in neurons is regulated by UNC-51 and UNC-14; in addition, UNC-51 is required for normal dauer morphogenesis of daf-2 mutant animals; UNC-51 is expressed in all C. elegans neurons and in body wall and pharyngeal muscles; in neurons, an UNC-51::GFP fusion protein shows punctate cytoplasmic localization in axons and cell bodies and partial co-localization with UNC-14 and UNC-5. | Paper_evidence | WBPaper00002050 | |||||
| WBPaper00002845 | |||||||||
| WBPaper00004362 | |||||||||
| WBPaper00006070 | |||||||||
| WBPaper00024595 | |||||||||
| WBPaper00028376 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 21 Jul 2008 00:00:00 | ||||||||
| Automated_description | Enables protein serine/threonine kinase activity. Involved in several processes, including determination of adult lifespan; nematode male tail tip morphogenesis; and regulation of axon extension. Located in axon and neuronal cell body. Expressed in body wall musculature; motor neurons; pharyngeal muscle cell; and touch receptor neurons. Is an ortholog of human ULK1 (unc-51 like autophagy activating kinase 1) and ULK2 (unc-51 like autophagy activating kinase 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | Y60A3A.1 | |||||||
| Corresponding_transcript | Y60A3A.1.1 | ||||||||
| Other_sequence (65) | |||||||||
| Associated_feature | WBsf669876 | ||||||||
| WBsf669877 | |||||||||
| WBsf982087 | |||||||||
| WBsf1003406 | |||||||||
| WBsf1021857 | |||||||||
| Experimental_info | RNAi_result (28) | ||||||||
| Expr_pattern | Expr731 | ||||||||
| Expr1492 | |||||||||
| Expr12441 | |||||||||
| Expr15294 | |||||||||
| Expr1021306 | |||||||||
| Expr1032857 | |||||||||
| Expr1161234 | |||||||||
| Expr2017884 | |||||||||
| Expr2036020 | |||||||||
| Drives_construct (17) | |||||||||
| Construct_product | WBCnstr00012519 | ||||||||
| WBCnstr00018490 | |||||||||
| WBCnstr00021075 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (150) | |||||||||
| Interaction (96) | |||||||||
| WBProcess | WBbiopr:00000003 | ||||||||
| Map_info | Map | V | Position | 24.4326 | Error | 0.019149 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | ozDf1 | |||||||
| ozDf2 | |||||||||
| Positive_clone | Y60A3A | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| YO#KOPUF | |||||||||
| Mapping_data | 2_point (12) | ||||||||
| Multi_point (36) | |||||||||
| Pos_neg_data | 298 | ||||||||
| 2143 | |||||||||
| 8972 | |||||||||
| 8980 | |||||||||
| Landmark_gene | |||||||||
| Reference (191) | |||||||||
| Method | Gene |
