WormBase Tree Display for Gene: WBGene00006785
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| WBGene00006785 | SMap | S_parent | Sequence | T07A5 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | unc-50 | Person_evidence | WBPerson261 | |||||
| Sequence_name | T07A5.2 | ||||||||
| Molecular_name | T07A5.2 | ||||||||
| T07A5.2.1 | |||||||||
| CE36501 | |||||||||
| Other_name | CELE_T07A5.2 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | unc-50 | ||||||||
| DB_info | Database | AceView | gene | 3L404 | |||||
| WormQTL | gene | WBGene00006785 | |||||||
| WormFlux | gene | WBGene00006785 | |||||||
| NDB | locus_tag | CELE_T07A5.2 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006785|UniProtKB=Q10045 | |||||||
| family | PTHR12841 | ||||||||
| NCBI | gene | 176443 | |||||||
| RefSeq | protein | NM_066878.5 | |||||||
| SwissProt | UniProtAcc | Q10045 | |||||||
| TREEFAM | TREEFAM_ID | TF105624 | |||||||
| UniProt_GCRP | UniProtAcc | Q10045 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:42 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 01 Oct 2007 12:05:44 | WBPerson2970 | Event | Acquires_merge | WBGene00011555 | ||||
| Acquires_merge | WBGene00011555 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00143101 | ||||||||
| Allele (57) | |||||||||
| Legacy_information | e306 : weak kinker slow but fairly active resistant to 1 mM levamisole sensitive to hypoosmotic shock. ES3 ME1. NA7 (e425 etc. : all similar to e306). | ||||||||
| [C.elegansII] e306 : weak kinker, slow but fairly active; resistant to 1 mM levamisole sensitive to hypoosmotic shock. Extracts lack levamisole binding. ES3 ME1. OA6: e425 etc. (all similar). Cloned: encodes predicted 301 aa novel protein, possible TM domain. [Lewis et al. 1980; MT; WS; ZZ] | |||||||||
| Strain | WBStrain00027163 | ||||||||
| WBStrain00027198 | |||||||||
| WBStrain00027199 | |||||||||
| WBStrain00032235 | |||||||||
| WBStrain00004144 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00056029 | ||||||||
| 00056030 | |||||||||
| 00056031 | |||||||||
| 00056032 | |||||||||
| 00056033 | |||||||||
| 00056034 | |||||||||
| 00056035 | |||||||||
| 00056036 | |||||||||
| Contained_in_operon | CEOP3832 | ||||||||
| Ortholog (35) | |||||||||
| Structured_description | Concise_description | unc-50 encodes an integral membrane protein orthologous to the Saccharomyces cerevisiae Golgi component Gmh1p; UNC-50 is required for regulating subtype-specific ionotropic acetylcholine receptor trafficking to the cell surface and thus, for normal synaptic transmission at the neuromuscular junction; UNC-50 is ubiquitously expressed from early embryogenesis to adulthood and localizes to the Golgi. | Paper_evidence | WBPaper00031010 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 29 Jul 2015 00:00:00 | ||||||||
| Automated_description | Involved in receptor localization to synapse and regulation of muscle contraction. Located in Golgi membrane. Expressed in several structures, including alimentary muscle; gonad; intestine; neurons; and vulval muscle. Is an ortholog of human UNC50 (unc-50 inner nuclear membrane RNA binding protein). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | T07A5.2 | |||||||
| Corresponding_transcript | T07A5.2.1 | ||||||||
| Other_sequence (51) | |||||||||
| Associated_feature | WBsf227435 | ||||||||
| WBsf227436 | |||||||||
| Experimental_info | RNAi_result (13) | ||||||||
| Expr_pattern | Expr4027 | ||||||||
| Expr4910 | |||||||||
| Expr4911 | |||||||||
| Expr1012237 | |||||||||
| Expr1032856 | |||||||||
| Expr1156300 | |||||||||
| Expr2017883 | |||||||||
| Expr2036019 | |||||||||
| Drives_construct | WBCnstr00012326 | ||||||||
| WBCnstr00034152 | |||||||||
| Construct_product | WBCnstr00012325 | ||||||||
| WBCnstr00034152 | |||||||||
| Microarray_results (23) | |||||||||
| Expression_cluster (106) | |||||||||
| Interaction (17) | |||||||||
| Map_info | Map | III | Position | 2.30916 | Error | 0.004481 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | nDp2 | |||||||
| Positive_clone | T07A5 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| Mapping_data | 2_point | 56 | |||||||
| 75 | |||||||||
| Multi_point (27) | |||||||||
| Pos_neg_data | 650 | ||||||||
| 1619 | |||||||||
| 2722 | |||||||||
| 3243 | |||||||||
| 5726 | |||||||||
| 5734 | |||||||||
| 804 | |||||||||
| 1629 | |||||||||
| Landmark_gene | |||||||||
| Reference (54) | |||||||||
| Remark | on same cosmid as unc-69; genetic map data indicate unc-69 left of unc-50 JAH 01/01 | ||||||||
| Method | Gene |
