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WormBase Tree Display for Gene: WBGene00006777

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WBGene00006777	SMap	S_parent	Sequence	C27H6
	Identity	Version	2
		Name	CGC_name	unc-41	Person_evidence	WBPerson261
			Sequence_name	C27H6.1
			Molecular_name	C27H6.1a
				C27H6.1a.1
				CE45344
				C27H6.1b
				CE45373
				C27H6.1c
				CE45298
				C27H6.1b.1
				C27H6.1c.1
			Other_name	tcf-1
				apt-10	Person_evidence	WBPerson625
				CELE_C27H6.1	Accession_evidence	NDB	BX284605
			Public_name	unc-41
		DB_info	Database	WormQTL	gene	WBGene00006777
				SignaLink	protein	WBGene00006777
				WormFlux	gene	WBGene00006777
				NDB	locus_tag	CELE_C27H6.1
				Panther	gene	CAEEL\|WormBase=WBGene00006777\|UniProtKB=P90761
					family	PTHR10529
				NCBI	gene	179387
				RefSeq	protein	NM_001269229.3
						NM_001269228.3
						NM_001269230.3
				SwissProt	UniProtAcc	P90761
				TREEFAM	TREEFAM_ID	TF300393
				UniProt_GCRP	UniProtAcc	P90761
		Species	Caenorhabditis elegans
		History	Version_change	1	07 Apr 2004 11:29:42	WBPerson1971	Event	Imported	Initial conversion from geneace
				2	06 Feb 2008 14:41:31	WBPerson2970	Event	Acquires_merge	WBGene00000167
							Name_change	Sequence_name	C27H6.1
								Other_name	apt-10
			Acquires_merge	WBGene00000167
		Status	Live
	Gene_info	Biotype	SO:0001217
		Gene_class	unc
		Reference_allele	WBVar00143075
		Allele (176)
		Legacy_information	e268 : weak kinker irregular jerky movement slightly small; VD1 VD2 DD1 cell bodies mispositioned usually anteriorly; RVG organization disrupted. ES3 ME0. NA9 (e252 e399 etc.). Similar phenotype in e262/Df.
			See also e1573
			[C.elegansII] e268 : weak kinker, irregular jerky movement, slightly small; VD1, VD2, DD1 cell bodies mispositioned, usually anteriorly; RVG organization disrupted; Ric; elevated acetycholine levels. e268/Df similar.ES3 ME0. OA8: e252, e399, e1175, e1294,cn252::Tc1 etc.(similar). Also anomalous alleles: e554, e1162 (normal acetylcholinelevels, larger size, sd Unc phenotype.) Cloned: partial sequence indicates novel predicted protein. [Nguyen et al. 1995; RM; TN]
		Strain	WBStrain00002568
			WBStrain00033383
			WBStrain00033384
			WBStrain00033407
			WBStrain00033413
			WBStrain00004269
			WBStrain00004387
			WBStrain00004139
		RNASeq_FPKM (74)
		GO_annotation (13)
		Ortholog	WBGene00070363	Caenorhabditis remanei	From_analysis	TreeFam
						Inparanoid_8
						WormBase-Compara
			WBGene00038645	Caenorhabditis briggsae	From_analysis	Hillier-set
						OrthoMCL
						OMA
						Inparanoid_8
						WormBase-Compara
			WBGene00158734	Caenorhabditis brenneri	From_analysis	OMA
						TreeFam
						Inparanoid_8
						WormBase-Compara
			WBGene00129115	Caenorhabditis japonica	From_analysis	TreeFam
						Inparanoid_8
						WormBase-Compara
			WBGene00162205	Caenorhabditis brenneri	From_analysis	TreeFam
						WormBase-Compara
			WBGene00231650	Brugia malayi	From_analysis	WormBase-Compara
			CBOVI.g1763	Caenorhabditis bovis	From_analysis	WormBase-Compara
			CSP21.g6035	Caenorhabditis parvicauda	From_analysis	WormBase-Compara
			CSP26.g11499	Caenorhabditis zanzibari	From_analysis	WormBase-Compara
			CSP28.g21484	Caenorhabditis panamensis	From_analysis	WormBase-Compara
			CSP29.g21662	Caenorhabditis becei	From_analysis	WormBase-Compara
			CSP31.g11833	Caenorhabditis uteleia	From_analysis	WormBase-Compara
			CSP31.g15491	Caenorhabditis uteleia	From_analysis	WormBase-Compara
			CSP31.g15493	Caenorhabditis uteleia	From_analysis	WormBase-Compara
			CSP32.g8717	Caenorhabditis sulstoni	From_analysis	WormBase-Compara
			CSP38.g5098	Caenorhabditis quiockensis	From_analysis	WormBase-Compara
			CSP39.g3997	Caenorhabditis waitukubuli	From_analysis	WormBase-Compara
			CSP40.g4027	Caenorhabditis tribulationis	From_analysis	WormBase-Compara
			Cang_2012_03_13_03252.g17928	Caenorhabditis angaria	From_analysis	WormBase-Compara
			Cang_2012_03_13_15613.g25099	Caenorhabditis angaria	From_analysis	WormBase-Compara
			Cni-unc-41	Caenorhabditis nigoni	From_analysis	WormBase-Compara
			Csp11.Scaffold629.g15792	Caenorhabditis tropicalis	From_analysis	WormBase-Compara
			Csp5_scaffold_00006.g403	Caenorhabditis sinica	From_analysis	WormBase-Compara
			FL83_20088	Caenorhabditis latens	From_analysis	WormBase-Compara
			OTIPU.nOt.2.0.1.g00299	Oscheius tipulae	From_analysis	WormBase-Compara
			Pan_g13552	Panagrellus redivivus	From_analysis	WormBase-Compara
			Sp34_50261900	Caenorhabditis inopinata	From_analysis	WormBase-Compara
			chrV_pilon.g15388	Caenorhabditis elegans	From_analysis	WormBase-Compara
			WBGene00242984	Onchocerca volvulus	From_analysis	WormBase-Compara
			WBGene00256611	Strongyloides ratti	From_analysis	WormBase-Compara
			WBGene00294434	Trichuris muris	From_analysis	WormBase-Compara
			SGD:S000001011	Saccharomyces cerevisiae	From_analysis	EnsEMBL-Compara
						Panther
			FB:FBgn0016975	Drosophila melanogaster	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			ZFIN:ZDB-GENE-050913-137	Danio rerio	From_analysis	EnsEMBL-Compara
						Hieranoid
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			ZFIN:ZDB-GENE-060929-28	Danio rerio	From_analysis	Hieranoid
						OrthoFinder
						OrthoInspector
						PhylomeDB
			HGNC:17003	Homo sapiens	From_analysis	Hieranoid
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			HGNC:30652	Homo sapiens	From_analysis	EnsEMBL-Compara
						Hieranoid
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			HGNC:30651	Homo sapiens	From_analysis	Hieranoid
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			MGI:1924307	Mus musculus	From_analysis	Hieranoid
						Inparanoid
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			MGI:1918272	Mus musculus	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			RGD:1311502	Rattus norvegicus	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			RGD:727878	Rattus norvegicus	From_analysis	Hieranoid
						Inparanoid
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
		Paralog	WBGene00000150	Caenorhabditis elegans	From_analysis	TreeFam
						Panther
						WormBase-Compara
			WBGene00001082	Caenorhabditis elegans	From_analysis	Panther
						WormBase-Compara
			WBGene00006829	Caenorhabditis elegans	From_analysis	Panther
						WormBase-Compara
			WBGene00000164	Caenorhabditis elegans	From_analysis	WormBase-Compara
		Structured_description	Concise_description	unc-41 encodes an ortholog of Drosophila STONED B (STNB) required for normal locomotion; a beta-strand in the mu-adaptin-like domain of UNC-41 binds the C2A domain of SNT-1, and this binding is required for SNT-1 endocytosis, punctate localization of UNC-41 in neurons, and transgenic rescue of unc-41(e268) animals; UNC-41 is also required for normal secretion of EGL-17 from P6.p cells, and for embryonic viability; UNC-41 is expressed in the larval and adult nervous system; UNC-41, like other stonins, is an adaptin, and by orthology with stonins is predicted to be a protein adaptor that helps sort SNT-1 endocytotically.	Paper_evidence	WBPaper00004907
						WBPaper00006219
						WBPaper00006525
						WBPaper00013412
						WBPaper00031006
						WBPaper00031369
					Curator_confirmed	WBPerson567
					Date_last_updated	06 Feb 2008 00:00:00
			Automated_description	Predicted to enable clathrin adaptor activity. Involved in positive regulation of locomotion. Located in synapse. Expressed in DD neuron; VD neuron; and cholinergic neurons. Is an ortholog of human STON2 (stonin 2).	Paper_evidence	WBPaper00065943
					Curator_confirmed	WBPerson324
						WBPerson37462
					Inferred_automatically	This description was generated automatically by a script based on data from the WS291 version of WormBase
					Date_last_updated	29 Nov 2023 00:00:00
	Molecular_info	Corresponding_CDS	C27H6.1a
			C27H6.1b
			C27H6.1c
		Corresponding_CDS_history	C27H6.1:wp218
		Corresponding_transcript	C27H6.1a.1
			C27H6.1b.1
			C27H6.1c.1
		Other_sequence (37)
		Associated_feature (14)
	Experimental_info	RNAi_result	WBRNAi00089949	Inferred_automatically	RNAi_primary
			WBRNAi00063263	Inferred_automatically	RNAi_primary
			WBRNAi00090109	Inferred_automatically	RNAi_primary
			WBRNAi00062995	Inferred_automatically	RNAi_primary
			WBRNAi00089721	Inferred_automatically	RNAi_primary
			WBRNAi00063002	Inferred_automatically	RNAi_primary
			WBRNAi00011280	Inferred_automatically	RNAi_primary
			WBRNAi00090267	Inferred_automatically	RNAi_primary
			WBRNAi00041380	Inferred_automatically	RNAi_primary
			WBRNAi00098506	Inferred_automatically	RNAi_primary
		Expr_pattern (11)
		Drives_construct	WBCnstr00003130
			WBCnstr00012971
			WBCnstr00015493
			WBCnstr00015494
		Construct_product	WBCnstr00012971
		Antibody	WBAntibody00002355
		Microarray_results (22)
		Expression_cluster (235)
		Interaction (23)
	Map_info	Map	V	Position	2.22339	Error	0.000715
		Well_ordered
		Positive	Inside_rearr	eDf1
			Positive_clone	C27H6	Inferred_automatically	From sequence, transcript, pseudogene data
		Mapping_data	2_point	131
				139
				947
			Multi_point (18)
			Pos_neg_data	307
				857
				865
				1739
				1763
				2170
				3074
				3113
	Reference (43)
	Method	Gene