WormBase Tree Display for Gene: WBGene00006777
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| WBGene00006777 | SMap | S_parent | Sequence | C27H6 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | unc-41 | Person_evidence | WBPerson261 | |||||
| Sequence_name | C27H6.1 | ||||||||
| Molecular_name | C27H6.1a | ||||||||
| C27H6.1a.1 | |||||||||
| CE45344 | |||||||||
| C27H6.1b | |||||||||
| CE45373 | |||||||||
| C27H6.1c | |||||||||
| CE45298 | |||||||||
| C27H6.1b.1 | |||||||||
| C27H6.1c.1 | |||||||||
| Other_name | tcf-1 | ||||||||
| apt-10 | Person_evidence | WBPerson625 | |||||||
| CELE_C27H6.1 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | unc-41 | ||||||||
| DB_info | Database | WormQTL | gene | WBGene00006777 | |||||
| SignaLink | protein | WBGene00006777 | |||||||
| WormFlux | gene | WBGene00006777 | |||||||
| NDB | locus_tag | CELE_C27H6.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006777|UniProtKB=P90761 | |||||||
| family | PTHR10529 | ||||||||
| NCBI | gene | 179387 | |||||||
| RefSeq | protein | NM_001269229.3 | |||||||
| NM_001269228.3 | |||||||||
| NM_001269230.3 | |||||||||
| SwissProt | UniProtAcc | P90761 | |||||||
| TREEFAM | TREEFAM_ID | TF300393 | |||||||
| UniProt_GCRP | UniProtAcc | P90761 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:42 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 06 Feb 2008 14:41:31 | WBPerson2970 | Event | Acquires_merge | WBGene00000167 | ||||
| Name_change | Sequence_name | C27H6.1 | |||||||
| Other_name | apt-10 | ||||||||
| Acquires_merge | WBGene00000167 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00143075 | ||||||||
| Allele (176) | |||||||||
| Legacy_information | e268 : weak kinker irregular jerky movement slightly small; VD1 VD2 DD1 cell bodies mispositioned usually anteriorly; RVG organization disrupted. ES3 ME0. NA9 (e252 e399 etc.). Similar phenotype in e262/Df. | ||||||||
| See also e1573 | |||||||||
| [C.elegansII] e268 : weak kinker, irregular jerky movement, slightly small; VD1, VD2, DD1 cell bodies mispositioned, usually anteriorly; RVG organization disrupted; Ric; elevated acetycholine levels. e268/Df similar.ES3 ME0. OA8: e252, e399, e1175, e1294,cn252::Tc1 etc.(similar). Also anomalous alleles: e554, e1162 (normal acetylcholinelevels, larger size, sd Unc phenotype.) Cloned: partial sequence indicates novel predicted protein. [Nguyen et al. 1995; RM; TN] | |||||||||
| Strain | WBStrain00002568 | ||||||||
| WBStrain00033383 | |||||||||
| WBStrain00033384 | |||||||||
| WBStrain00033407 | |||||||||
| WBStrain00033413 | |||||||||
| WBStrain00004269 | |||||||||
| WBStrain00004387 | |||||||||
| WBStrain00004139 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (13) | |||||||||
| Ortholog (42) | |||||||||
| Paralog | WBGene00000150 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00001082 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00006829 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00000164 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | unc-41 encodes an ortholog of Drosophila STONED B (STNB) required for normal locomotion; a beta-strand in the mu-adaptin-like domain of UNC-41 binds the C2A domain of SNT-1, and this binding is required for SNT-1 endocytosis, punctate localization of UNC-41 in neurons, and transgenic rescue of unc-41(e268) animals; UNC-41 is also required for normal secretion of EGL-17 from P6.p cells, and for embryonic viability; UNC-41 is expressed in the larval and adult nervous system; UNC-41, like other stonins, is an adaptin, and by orthology with stonins is predicted to be a protein adaptor that helps sort SNT-1 endocytotically. | Paper_evidence | WBPaper00004907 | |||||
| WBPaper00006219 | |||||||||
| WBPaper00006525 | |||||||||
| WBPaper00013412 | |||||||||
| WBPaper00031006 | |||||||||
| WBPaper00031369 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 06 Feb 2008 00:00:00 | ||||||||
| Automated_description | Predicted to enable clathrin adaptor activity. Involved in positive regulation of locomotion. Located in synapse. Expressed in DD neuron; VD neuron; and cholinergic neurons. Is an ortholog of human STON2 (stonin 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C27H6.1a | |||||||
| C27H6.1b | |||||||||
| C27H6.1c | |||||||||
| Corresponding_CDS_history | C27H6.1:wp218 | ||||||||
| Corresponding_transcript | C27H6.1a.1 | ||||||||
| C27H6.1b.1 | |||||||||
| C27H6.1c.1 | |||||||||
| Other_sequence (37) | |||||||||
| Associated_feature (14) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00089949 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00063263 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00090109 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00062995 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00089721 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00063002 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00011280 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00090267 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00041380 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00098506 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00003130 | ||||||||
| WBCnstr00012971 | |||||||||
| WBCnstr00015493 | |||||||||
| WBCnstr00015494 | |||||||||
| Construct_product | WBCnstr00012971 | ||||||||
| Antibody | WBAntibody00002355 | ||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (235) | |||||||||
| Interaction (23) | |||||||||
| Map_info | Map | V | Position | 2.22339 | Error | 0.000715 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | eDf1 | |||||||
| Positive_clone | C27H6 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| Mapping_data | 2_point | 131 | |||||||
| 139 | |||||||||
| 947 | |||||||||
| Multi_point (18) | |||||||||
| Pos_neg_data | 307 | ||||||||
| 857 | |||||||||
| 865 | |||||||||
| 1739 | |||||||||
| 1763 | |||||||||
| 2170 | |||||||||
| 3074 | |||||||||
| 3113 | |||||||||
| Reference (43) | |||||||||
| Method | Gene |
