e271 : weak kinker dumpyish slow but fairly active Egl; variable defects in VD and DD commissures. ES2 ME0. NA4 (e1430 (pka unc-91) n324 n473).
See unc-40.
See also e1430, e1478, n324
[C.elegansII] e271 : weak kinker, dumpyish, slow but fairly active; Egl; variable defects in VD and DD commissures; general failure in ventralward migrations. ES2 ME0. OA>5: e1430 (pka unc-91, e1478,n324, n473, ev457 (probable null), etc. Cloned: encodes predicted large protein with TM domain,extracellular fibronectin and Ig domains; related to chicken neogenin, human tumor suppressor DCC. unc-40:GFP expressed in cells undergoing circumferential migrations or extensions. [Hedgecock et al. 1990; NW]
unc-40 encodes a netrin receptor that is required to guide dorsal-ventral cell and axon migrations, and is required for correct polarization and migration of the neuroblasts QL and QR; UNC-40 function in both UNC-5-dependent and UNC-5-independent signaling pathways to regulate cell and axon migrations; UNC-5-dependent signaling is likely enhanced by UNC-129, a TGF-beta signaling molecule that is expressed in a gradient opposite that of UNC-6 netrin; UNC-40 is also required, along with UNC-6, for mediating anchor cell (AC) invasion, likely by regulating formation of an AC invasive membrane domain; an UNC-40::GFP fusion protein is expressed on the surface of motile cells and pioneering neurons.
Enables netrin receptor activity and protein domain specific binding activity. Involved in several processes, including axon guidance; regulation of locomotion; and sex differentiation. Acts upstream of or within dendrite morphogenesis and distal tip cell migration. Located in axonal growth cone and cell projection membrane. Part of receptor complex. Expressed in several structures, including hermaphrodite somatic gonadal cell; motor neurons; neuroblasts; somatic nervous system; and touch receptor neurons. Human ortholog(s) of this gene implicated in colorectal cancer; congenital mirror movement disorder; and esophagus squamous cell carcinoma. Is an ortholog of human DCC (DCC netrin 1 receptor) and NEO1 (neogenin 1).