WormBase Tree Display for Gene: WBGene00006773

WBGene00006773 SMap: S_parent: Sequence: W02D3
  Identity: Version: 1
    Name: CGC_name: unc-37 Person_evidence: WBPerson261
      Sequence_name: W02D3.9
      Molecular_name: W02D3.9
        W02D3.9.1
        CE14434
      Other_name: let-76
        ESG Accession_evidence: EMBL AF001271
              AF001272
        CELE_W02D3.9 Accession_evidence: NDB BX284601
      Public_name: unc-37
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:42 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Reference_allele: WBVar00143071
    Allele (43)
    Legacy_information: e262 : weak coiler fairly active. ES2 ME1. NA1.
      s80 : L1 lethal. NA1.
      L1 lethal
      See also s80
      [C.elegansII] e262 : weak coiler, fairly active; phenotype similar to Unc-4. ES2 ME1. OA2 (recessive): s80 (pka let-76, L1 lethal), h763 (Unc, adult sterile). Also dominant suppressors of unc-4(e2322ts):wd14, wd16, wd17, wd18 (no phenotype alone, allele-specific dominant suppressors of e2322). Intragenic revertants, e.g. wd17wd19, resembl eh763. Cloned: encodes predicted 614 aa protein with similarity to groucho-related transcription factors, 6 WD40 repeats in C-term. [Miller et al. 1993; NC]
    Strain (15)
    RNASeq_FPKM (74)
    GO_annotation (35)
    Contained_in_operon: CEOP1348
    Ortholog: WBGene00060607 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00026796 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00164235 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00159677 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00126030 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00226398 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g10348 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g728 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g2021 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g3783 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g11168 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g8652 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g8072 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g10998 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g8032 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g16538 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00940.g15033 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-unc-37 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold630.g17066 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00236.g7669 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_18692 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_001052 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g10764 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g11230 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_10297300 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrI_pilon.g1233 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00237873 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00195123 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00275689 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00263299 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00287848 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0001139 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-990415-86 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-050208-677 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-030131-2826 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-990415-85 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:11837 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:11838 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:11839 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:11840 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:30788 Homo sapiens From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      HGNC:53648 Homo sapiens From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      MGI:104636 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:104635 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:104634 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:104633 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:2149593 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      MGI:5439433 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      RGD:3868 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:620292 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1306665 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:1561530 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      RGD:1309237 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:6498598 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
            PhylomeDB
    Structured_description: Concise_description: unc-37 encodes a transducin-like WD-repeat protein orthologous to Drosophila Groucho; unc-37 plays an essential role in embryonic and neuronal fate specification; unc-37 genetically interacts with components of the transcriptional Mediator complex. Paper_evidence: WBPaper00002798
            WBPaper00005042
            WBPaper00005136
            WBPaper00030973
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 07 May 2010 00:00:00
      Automated_description: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and transcription corepressor activity. Involved in chemical synaptic transmission; regulation of axonogenesis; and regulation of synapse structure or activity. Located in nucleus. Expressed in several structures, including germ line; head; and tail. Is an ortholog of human TLE2 (TLE family member 2, transcriptional corepressor). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: EFO:MONDO:0014769 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:30788)
  Molecular_info: Corresponding_CDS: W02D3.9
    Corresponding_transcript: W02D3.9.1
    Other_sequence (80)
    Associated_feature: WBsf034259
      WBsf649254
      WBsf664356
      WBsf664357
      WBsf664358
      WBsf983991
      WBsf1009987
      WBsf219629
      WBsf219630
    Transcription_factor: WBTranscriptionFactor000434
  Experimental_info: RNAi_result (34)
    Expr_pattern (11)
    Drives_construct: WBCnstr00002546
      WBCnstr00004371
      WBCnstr00006094
      WBCnstr00006107
      WBCnstr00006110
      WBCnstr00010892
    Construct_product: WBCnstr00006110
      WBCnstr00010892
    Antibody: WBAntibody00000145
    Microarray_results (22)
    Expression_cluster (138)
    Interaction (324)
  Map_info: Map: I Position: 1.30432 Error: 0.000643
    Well_ordered
    Positive: Inside_rearr: qDf16
        nDp1
      Positive_clone: W02D3 Person_evidence: WBPerson422
            WBPerson43
          Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 15
        7055
      Multi_point (24)
      Pos_neg_data (41)
  Reference (129)
  Remark: [Miller D and Barnes T] unc-37 encodes a homolog of Drosophila groucho and therefore is likely to function as a transcription cofactor protein.
  Method: Gene