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WormBase Tree Display for Gene: WBGene00006750

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Name Class

WBGene00006750SMapS_parentSequenceT10A3
IdentityVersion1
NameCGC_nameunc-10Person_evidenceWBPerson261
Sequence_nameT10A3.1
Molecular_name (18)
Other_namerim-1
RimPaper_evidenceWBPaper00013595
CELE_T10A3.1Accession_evidenceNDBBX284606
Public_nameunc-10
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:41WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classunc
Reference_alleleWBVar00142961
Allele (153)
Legacy_informatione102 : weak coiler tends to back loopy movement in reverse; fairly active slightly small and thin. ES3 ME2. NA2 (e126).
[C.elegansII] e102 : weak coiler, tends to back, loopy movement in reverse; fairly active; slightly small and thin; Ric. ES3 ME2. OA1: e126. [Brenner 1974; Nguyen et al. 1995]
[Nonet M] unc-10(e102) was phenotypically rescued by both cosmid C34H12 and a 16 kb BamHI/KpnI subclone of this cosmid that contains effectively only the rim-1 gene. The rim-1 gene (rim for Rab Interacting Molecule) is the combined genefinder products T10A3.1 and K03A1.3 (with several mistakes in the prediction by genefinder). Furthermore, unc-10(md330) and unc-10(md1117) both contain deletions of the vast majority of the rim-1 gene. Specifically, md1117 deleted 8.6 kb that extends from approximately 500 bp 5' of the atg to 200 bp 3' of the TAA of the rim-1 gene product.
[Nonet M] Encodes Rab-3 interacting protein.
StrainWBStrain00002752
WBStrain00027194
WBStrain00029061
WBStrain00004100
WBStrain00005485
WBStrain00005508
WBStrain00005509
WBStrain00051853
RNASeq_FPKM (74)
GO_annotation (32)
Ortholog (51)
Structured_descriptionConcise_descriptionunc-10 encodes a protein with zinc-finger, Q/N-rich, PDZ, and C2 domains that is homologous to vertebrate Rim1, a presynaptic protein which binds, and effects the activity of, synaptic vesicle-associated GTP-Rab3; UNC-10 is required for normal locomotion and synaptic transmission, and localizes to a subdomain of presynaptic termini, where it probably acts to regulate the priming step of presynaptic vesicle fusion by promoting conformational changes in syntaxin.Paper_evidenceWBPaper00002487
WBPaper00004891
WBPaper00005068
WBPaper00012788
WBPaper00012830
WBPaper00012882
WBPaper00012897
WBPaper00013003
Curator_confirmedWBPerson1843
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionEnables small GTPase binding activity. Involved in several processes, including chemical synaptic transmission; defecation; and positive regulation of cholinergic synaptic transmission. Located in axon and presynaptic active zone. Expressed in dorsal nerve cord; nerve ring; nervous system; uv1; and ventral nerve cord. Is an ortholog of human RIMS1 (regulating synaptic membrane exocytosis 1).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDST10A3.1a
T10A3.1b
T10A3.1c
T10A3.1d
T10A3.1e
T10A3.1f
Corresponding_transcriptT10A3.1a.1
T10A3.1b.1
T10A3.1c.1
T10A3.1d.1
T10A3.1e.1
T10A3.1f.1
Other_sequence (30)
Associated_feature (22)
Experimental_infoRNAi_result (19)
Expr_patternChronogram1591
Expr2418
Expr14780
Expr15235
Expr15236
Expr1017493
Expr1032824
Expr1156587
Expr2017837
Expr2035973
Drives_constructWBCnstr00003280
WBCnstr00034173
Construct_product (11)
AntibodyWBAntibody00000412
WBAntibody00000866
WBAntibody00001456
WBAntibody00001656
WBAntibody00001729
WBAntibody00002171
Microarray_results (30)
Expression_cluster (208)
InteractionWBInteraction000035668
WBInteraction000038235
WBInteraction000049017
WBInteraction000112791
WBInteraction000113770
WBInteraction000114671
WBInteraction000126291
WBInteraction000126343
WBInteraction000126345
WBInteraction000126405
WBInteraction000126559
WBInteraction000126635
WBInteraction000134619
WBInteraction000160349
WBInteraction000166757
WBInteraction000166866
WBInteraction000166953
WBInteraction000167492
WBInteraction000173992
WBInteraction000175570
WBInteraction000178045
WBInteraction000178046
WBInteraction000178047
WBInteraction000188216
WBInteraction000203613
WBInteraction000204742
WBInteraction000204743
WBInteraction000204744
WBInteraction000229511
WBInteraction000229512
WBInteraction000229513
WBInteraction000229514
WBInteraction000229515
WBInteraction000229516
WBInteraction000232224
WBInteraction000250100
WBInteraction000277217
WBInteraction000294878
WBInteraction000299279
WBInteraction000306028
WBInteraction000322458
WBInteraction000341645
WBInteraction000341646
WBInteraction000354905
WBInteraction000359943
WBInteraction000359944
WBInteraction000361252
WBInteraction000380125
WBInteraction000399489
WBInteraction000399490
WBInteraction000410776
WBInteraction000434105
WBInteraction000447522
WBInteraction000469049
WBInteraction000471265
WBInteraction000471266
WBInteraction000501292
WBInteraction000501720
WBInteraction000502148
WBInteraction000502149
WBInteraction000502961
WBInteraction000502962
WBInteraction000520028
WBInteraction000540982
WBInteraction000543488
WBInteraction000544486
WBInteraction000544487
WBInteraction000544604
WBInteraction000544708
WBInteraction000544709
WBInteraction000555755
WBInteraction000556685
WBInteraction000556819
WBInteraction000558409
WBInteraction000560298
WBInteraction000560299
WBInteraction000566964
WBInteraction000570720
WBInteraction000574266
WBInteraction000578488
WBInteraction000583717
WBInteraction000584115
Map_infoMapXPosition-1.7816Error0.001118
Well_ordered
PositivePositive_cloneC34H12
T10A3Person_evidenceWBPerson451
Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_data2_point147
182
3912
3913
6198
Multi_point (23)
Pos_neg_data (13)
Reference (108)
RemarkSequence connection from [Koushika SP, Nonet M]
Other name from JA Hodgkin, 09/02/2002
unc-10 is the same as rim-1 and therefore rim-1 was merged into unc-10 based on advice from JAH
MethodGene