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WormBase Tree Display for Gene: WBGene00006722

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Name Class

WBGene00006722EvidencePerson_evidenceWBPerson2549
WBPerson6733
SMapS_parentSequenceF46E10
IdentityVersion1
NameCGC_nameubh-2
Sequence_nameY40G12A.2
Molecular_nameY40G12A.2
Y40G12A.2.1
CE52436
Other_nameCELE_Y40G12A.2Accession_evidenceNDBBX284605
Public_nameubh-2
DB_infoDatabase (12)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:41WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classubh
Allele (14)
RNASeq_FPKM (74)
GO_annotation (13)
Contained_in_operonCEOP5120
Ortholog (30)
ParalogWBGene00006721Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00006723Caenorhabditis elegansFrom_analysisInparanoid_8
Panther
WormBase-Compara
WBGene00006724Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
Structured_descriptionAutomated_descriptionEnables deNEDDylase activity and deubiquitinase activity. Involved in protein deneddylation. Predicted to be located in cytoplasm. Expressed in intestinal cell and neurons. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; and hereditary spastic paraplegia (multiple). Is an ortholog of human UCHL1 (ubiquitin C-terminal hydrolase L1) and UCHL3 (ubiquitin C-terminal hydrolase L3).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:10652Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12513)
DOID:0070455Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12513)
DOID:14330Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12513)
DOID:0112344Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12513)
Molecular_infoCorresponding_CDSY40G12A.2
Corresponding_CDS_historyY40G12A.2:wp262
Corresponding_transcriptY40G12A.2.1
Other_sequence (23)
Associated_featureWBsf233814
Experimental_infoRNAi_resultWBRNAi00015094Inferred_automaticallyRNAi_primary
WBRNAi00098015Inferred_automaticallyRNAi_primary
WBRNAi00076786Inferred_automaticallyRNAi_primary
WBRNAi00098010Inferred_automaticallyRNAi_primary
WBRNAi00056335Inferred_automaticallyRNAi_primary
WBRNAi00056334Inferred_automaticallyRNAi_primary
Expr_patternExpr15526
Expr1019739
Expr1159823
Expr2017719
Expr2035857
Drives_constructWBCnstr00042222
Construct_productWBCnstr00042222
Microarray_results (15)
Expression_clusterWBPaper00031040:TGF-beta_adult_downregulated
WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
WBPaper00037950:all-neurons_L2-larva_expressed
WBPaper00037950:AVA-neuron_L1-larva_expressed
WBPaper00037950:BAG-neuron_blastula-embryo_expressed
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:coelomocytes_L2-larva_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:excretory-cell_L2-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
WBPaper00037950:germline-precursors_blastula-embryo_expressed
WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00037950:intestine_L1-larva_expressed
WBPaper00037950:intestine_L2-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00044426:rotenone_24h_upregulated
WBPaper00044656:tatn-1(qd182)_downregulated
WBPaper00044736:flat_dev_expression
WBPaper00045521:Gender_Neutral
WBPaper00048926:miaserin_upregulated_adult-day5
WBPaper00048988:neuron_expressed
WBPaper00049942:hsf-1(RNAi)_upregulated
WBPaper00050344:AFD-neuron_enriched
WBPaper00050344:PLM-neuron_enriched
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050990:intestine_enriched
WBPaper00050990:intestine_expressed
WBPaper00051039:germline_enriched
WBPaper00053184:sma-2(rax5)_downregulated
WBPaper00053184:sma-4(rax3)_downregulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053321:PGCs_enriched_NuGen
WBPaper00055354:Psora-Allantoin_upregulated
WBPaper00055354:Rapamycin-Metformin_upregulated
WBPaper00055354:Rifampicin-Allantoin_upregulated
WBPaper00055648:germline_expressed
WBPaper00058691:sin-3(tm1276)_downregulated
WBPaper00061340:AIN
WBPaper00061340:ALA
WBPaper00061340:AUA
WBPaper00061340:AVA
WBPaper00061340:AVD
WBPaper00061340:AVK
WBPaper00061340:AVL
WBPaper00061340:DVC
WBPaper00061340:PVP
WBPaper00061340:RIC
WBPaper00061340:RIM
WBPaper00061340:RME
WBPaper00061340:RMED
WBPaper00061340:SIA
WBPaper00061902:camt-1(ok515)_regulated_RMG
WBPaper00062159:hda-2(ok1479)_downregulated
WBPaper00062325:muscle_enriched_coding-RNA
WBPaper00064315:mrg-1(qa6200)_downregulated_PGCs
WBPaper00064494:postdauer_downregulated_AWA
WBPaper00064716:paraquat_upregulated
WBPaper00065096:Day10_vs_Day1_upregulated
WBPaper00065841:51_1
WBPaper00065993:glp-1(e2141)_downregulated
WBPaper00066085:sin-3(syb2172)_downregulated
WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
cgc4489_group_12
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00026980:intestine_enriched
WBPaper00031252:AIN-1_IP_enriched
WBPaper00035084:L2_enriched_AIN-2_IP
WBPaper00035084:L3_enriched_AIN-2_IP
WBPaper00035084:L4_enriched_AIN-2_IP
WBPaper00036123:Atrazine_regulated
WBPaper00036286:Pattern_B
[cgc6390]:herm_sex-enriched
Interaction (18)
Map_infoMapVPosition-0.04818Error0.006448
PositivePositive_cloneY40G12AInferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
ReferenceWBPaper00010020
WBPaper00025802
WBPaper00030133
WBPaper00038491
WBPaper00055090
WBPaper00060977
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene