WormBase Tree Display for Gene: WBGene00006721
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| WBGene00006721 | Evidence | Person_evidence | WBPerson2549 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| WBPerson6733 | |||||||||
| SMap | S_parent | Sequence | F46E10 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | ubh-1 | |||||||
| Sequence_name | F46E10.8 | ||||||||
| Molecular_name | F46E10.8 | ||||||||
| F46E10.8.1 | |||||||||
| CE20818 | |||||||||
| Other_name | F46E10.f | Curator_confirmed | WBPerson1983 | ||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| CELE_F46E10.8 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | ubh-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ubh | ||||||||
| Allele (25) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (21) | |||||||||
| Contained_in_operon | CEOP5120 | ||||||||
| Ortholog (39) | |||||||||
| Paralog | WBGene00006722 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00006723 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00006724 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | ubh-1 encodes a putative ubiquitin C-terminal hydrolase orthologous to human UCHL1, that catalyzes the hydrolysis of C-terminal ubiquitinyl esters; C. elegans has three ubiquitin C-terminal hydrolase orthologs-ubh-1, ubh-2 and ubh-3; studies indicate that the ubh genes maybe be involved in aging, as they play a role in cellular senescence. | Paper_evidence | WBPaper00027616 | |||||
| WBPaper00035660 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 15 Jul 2013 00:00:00 | ||||||||
| Automated_description | Enables deNEDDylase activity and deubiquitinase activity. Involved in negative regulation of dauer larval development; positive regulation of transforming growth factor beta receptor signaling pathway; and protein deneddylation. Predicted to be located in cytoplasm. Expressed in amphid neurons and intestinal cell. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; and hereditary spastic paraplegia (multiple). Is an ortholog of human UCHL1 (ubiquitin C-terminal hydrolase L1) and UCHL3 (ubiquitin C-terminal hydrolase L3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00035660 | ||||
| Accession_evidence | OMIM | 613643 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 15 Jul 2013 00:00:00 | ||||||||
| Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12513) | |||||
| DOID:0070455 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12513) | ||||||
| DOID:14330 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12513) | ||||||
| DOID:0112344 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12513) | ||||||
| Disease_relevance | Mutations in human ubiquitin C-terminal hydrolase L1 (UCHL1/PARK5; neuron specific) are associated with Parkinson''s disease (PD); UCH-L1 protects against protein aggregation disorders such as Alzheimer disease and PD and is part of the ubiquitin proteasome system; C. elegans is used as a model system to study the genetic interactions and molecular functions of PARK protein orthologs; studies that knock-down the ubh genes in elegans (ubh-1, ubh-2, ubh-3) indicate that they are involved in cellular senescence and thus aging. | Homo sapiens | Paper_evidence | WBPaper00027616 | |||||
| WBPaper00035660 | |||||||||
| Accession_evidence | OMIM | 613643 | |||||||
| 191342 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 15 Jul 2013 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000209 | ||||||||
| Molecular_info | Corresponding_CDS | F46E10.8 | |||||||
| Corresponding_transcript | F46E10.8.1 | ||||||||
| Other_sequence (36) | |||||||||
| Associated_feature | WBsf669046 | ||||||||
| WBsf669047 | |||||||||
| WBsf669048 | |||||||||
| WBsf1000286 | |||||||||
| WBsf233815 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00102982 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00102992 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00102972 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00015095 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00056335 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00094630 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00047527 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00076438 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr15525 | ||||||||
| Expr1027646 | |||||||||
| Expr1151366 | |||||||||
| Expr2017718 | |||||||||
| Expr2035856 | |||||||||
| Drives_construct | WBCnstr00042221 | ||||||||
| Construct_product | WBCnstr00042221 | ||||||||
| Microarray_results (17) | |||||||||
| Expression_cluster (153) | |||||||||
| Interaction (17) | |||||||||
| Map_info | Map | V | Position | -0.032234 | Error | 0.006589 | |||
| Positive | Positive_clone | F46E10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00010020 | ||||||||
| WBPaper00025802 | |||||||||
| WBPaper00027616 | |||||||||
| WBPaper00030133 | |||||||||
| WBPaper00030965 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00060977 | |||||||||
| WBPaper00063803 | |||||||||
| WBPaper00064934 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
