tsn-1 encodes the C. elegans ortholog of Tudor-SN (tudor staphylococcal nuclease); TSN-1 is a component of the RNA-induced silencing complex (RISC) and its activity is required for proper function of the let-7 miRNA in vivo; TSN-1 is found in both the nucleus and the cytosol.
Predicted to enable RNA binding activity and nuclease activity. Involved in miRNA-mediated post-transcriptional gene silencing. Located in cytosol and nucleus. Part of RISC complex. Expressed in head and tail. Is an ortholog of human SND1 (staphylococcal nuclease and tudor domain containing 1).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.