WormBase Tree Display for Gene: WBGene00006498
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| WBGene00006498 | SMap | S_parent | Sequence | CHROMOSOME_III | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 4 | |||||||
| Name | CGC_name | ten-1 | Person_evidence | WBPerson104 | |||||
| Sequence_name | R13F6.4 | ||||||||
| Molecular_name (16) | |||||||||
| Other_name | tag-152 | Person_evidence | WBPerson201 | ||||||
| mnm-5 | Paper_evidence | WBPaper00036313 | |||||||
| Person_evidence | WBPerson488 | ||||||||
| CELE_R13F6.4 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | ten-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:40 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 26 Jul 2005 11:46:16 | WBPerson2970 | Name_change | CGC_name | ten-1 | ||||
| Other_name | tag-152 | ||||||||
| 3 | 20 Oct 2005 09:04:04 | WBPerson1867 | Event | Acquires_merge | WBGene00017903 | ||||
| 4 | 17 Aug 2010 12:12:13 | WBPerson2970 | Event | Acquires_merge | WBGene00003383 | ||||
| Name_change | Other_name | mnm-1 | |||||||
| Acquires_merge | WBGene00003383 | ||||||||
| WBGene00017903 | |||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ten | ||||||||
| Allele (374) | |||||||||
| Strain | WBStrain00003335 | ||||||||
| WBStrain00003336 | |||||||||
| WBStrain00031159 | |||||||||
| WBStrain00035839 | |||||||||
| WBStrain00050786 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (38) | |||||||||
| Ortholog (54) | |||||||||
| Paralog | WBGene00011326 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WBGene00017892 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00018237 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | ten-1 encodes a type II transmembrane protein containing EGF-like repeats that is the C. elegans ortholog of Drosophila Ten-m/Odz and vertebrate teneurins (OMIM:300588); in C. elegans, TEN-1 is required for proper development of the gonadal and pharyngeal basement membranes and for proper axonal placement and hypodermal morphogenesis; ten-1 and phy-1 act in parallel influencing the connection between epidermis and muscle during embryonic development; TEN-1 acts as an epidermal receptor for the BM collagens modified by PHY-1 and secreted by the muscle cells; loss of P4H function in ten-1 null mutants results in embryonic lethality due to arrest during late elongation with morphological defects; ten-1; phy-1 embryos have defects in epidermal development and body wall muscles due to basement membrane defects in arrested embryos; TEN-1 is expressed in the embryo and in multiple tissues during postembryonic development including the somatic gonad founder cells Z1 and Z4 and their descendants, as well as in six marginal cells and the M2 neurons in the pharynx; in the embryo, ten-1 expression overlaps with that of lat-1 in the dorsal left epidermoblasts; as ten-1 and lat-1 also display genetic interactions during embryonic development, the overlapping expression patterns suggest that these two genes have overlapping functions during embryogenesis. | Paper_evidence | WBPaper00004588 | |||||
| WBPaper00006025 | |||||||||
| WBPaper00025239 | |||||||||
| WBPaper00032026 | |||||||||
| WBPaper00036313 | |||||||||
| WBPaper00039988 | |||||||||
| WBPaper00041503 | |||||||||
| Curator_confirmed | WBPerson12884 | ||||||||
| WBPerson1843 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 22 Oct 2012 00:00:00 | ||||||||
| Automated_description | Involved in several processes, including axon development; body morphogenesis; and gonad development. Located in nucleus and plasma membrane. Expressed in several structures, including body muscle cell; gonad; hypodermis; interfacial epithelial cell; and neurons. Human ortholog(s) of this gene implicated in essential tremor 5. Is an ortholog of human TENM2 (teneurin transmembrane protein 2) and TENM3 (teneurin transmembrane protein 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | EFO:MONDO:0000170 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:29944) | ||||
| DOID:0111432 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:29945) | ||||||
| DOID:9975 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:29944) | ||||||
| Molecular_info | Corresponding_CDS | R13F6.4a | |||||||
| R13F6.4c | |||||||||
| R13F6.4d | |||||||||
| R13F6.4e | |||||||||
| R13F6.4f | |||||||||
| Corresponding_CDS_history | R13F6.4:wp82 | ||||||||
| R13F6.4a:wp229 | |||||||||
| R13F6.4b:wp142 | |||||||||
| R13F6.4d:wp193 | |||||||||
| Corresponding_transcript | R13F6.4a.1 | ||||||||
| R13F6.4a.2 | |||||||||
| R13F6.4c.1 | |||||||||
| R13F6.4d.1 | |||||||||
| R13F6.4e.1 | |||||||||
| R13F6.4f.1 | |||||||||
| Other_sequence | JI163882.1 | ||||||||
| CBC07315_1 | |||||||||
| CR01340 | |||||||||
| CRC08247_1 | |||||||||
| CRC01406_1 | |||||||||
| CR09660 | |||||||||
| CR08459 | |||||||||
| Associated_feature (48) | |||||||||
| Experimental_info | RNAi_result (18) | ||||||||
| Expr_pattern (14) | |||||||||
| Drives_construct (11) | |||||||||
| Construct_product | WBCnstr00005422 | ||||||||
| WBCnstr00008913 | |||||||||
| WBCnstr00008960 | |||||||||
| WBCnstr00034335 | |||||||||
| Antibody | WBAntibody00000932 | ||||||||
| WBAntibody00000933 | |||||||||
| Microarray_results (38) | |||||||||
| Expression_cluster (152) | |||||||||
| Interaction (12) | |||||||||
| Map_info | Map | III | Position | -0.935519 | Error | 0.002543 | |||
| Positive | Positive_clone | R13F6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4762 | |||||||
| 4976 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (21) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
