WormBase Tree Display for Gene: WBGene00006438
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| WBGene00006438 | SMap | S_parent | Sequence | CHROMOSOME_IV | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | nrfl-1 | Person_evidence | WBPerson18435 | |||||
| Sequence_name | C01F6.6 | ||||||||
| Molecular_name (30) | |||||||||
| Other_name | tag-60 | Person_evidence | WBPerson201 | ||||||
| mpz-2 | Person_evidence | WBPerson260 | |||||||
| CELE_C01F6.6 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | nrfl-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:40 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 07 Feb 2012 16:30:56 | WBPerson2970 | Name_change | CGC_name | mpz-2 | ||||
| Other_name | tag-60 | ||||||||
| 3 | 20 Jul 2012 14:03:23 | WBPerson2970 | Name_change | CGC_name | nrfl-1 | ||||
| Other_name | mpz-2 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | nrfl | ||||||||
| Allele (133) | |||||||||
| Strain | WBStrain00001222 | ||||||||
| WBStrain00035676 | |||||||||
| WBStrain00036880 | |||||||||
| WBStrain00031357 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (13) | |||||||||
| Ortholog (36) | |||||||||
| Structured_description | Concise_description | nrfl-1encodes, by alternative splicing, five isoforms of an ortholog of Drosophila SIP1 that maintains epithelial integrity via regulation of Moesin activity, and of the human SLC9A3R1 (OMIM:604990), SLC9A3R2 (OMIM:606553), PDZK1 (OMIM:603831), and PDZD3(OMIM:607146) proteins that regulate plasma membrane exchanger activity; in C. elegans, nrfl-1 is required for normally short lifespan and for normal acetylcholine neurotransmission; large-scale expression studies report that nrfl-1 is expressed in larval and adult pharynx, intestine, excretory cell, and tail cells. | Paper_evidence | WBPaper00006525 | |||||
| WBPaper00026643 | |||||||||
| WBPaper00026667 | |||||||||
| WBPaper00031006 | |||||||||
| WBPaper00031504 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 06 Jan 2011 00:00:00 | ||||||||
| Automated_description | Enables protein-membrane adaptor activity. Predicted to be involved in protein localization to plasma membrane. Located in apical plasma membrane. Expressed in excretory canal; pharyngeal muscle cell; and tail. Human ortholog(s) of this gene implicated in hypophosphatemic nephrolithiasis/osteoporosis 2. Is an ortholog of human NHERF1 (NHERF family PDZ scaffold protein 1) and NHERF2 (NHERF family PDZ scaffold protein 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0080078 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11075) | ||||
| Molecular_info | Corresponding_CDS | C01F6.6a | |||||||
| C01F6.6b | |||||||||
| C01F6.6c | |||||||||
| C01F6.6d | |||||||||
| C01F6.6e | |||||||||
| C01F6.6f | |||||||||
| C01F6.6g | |||||||||
| C01F6.6h | |||||||||
| C01F6.6i | |||||||||
| C01F6.6j | |||||||||
| Corresponding_CDS_history | C01F6.6:wp46 | ||||||||
| C01F6.6:wp80 | |||||||||
| Corresponding_transcript | C01F6.6a.1 | ||||||||
| C01F6.6b.1 | |||||||||
| C01F6.6c.1 | |||||||||
| C01F6.6d.1 | |||||||||
| C01F6.6e.1 | |||||||||
| C01F6.6f.1 | |||||||||
| C01F6.6g.1 | |||||||||
| C01F6.6h.1 | |||||||||
| C01F6.6i.1 | |||||||||
| C01F6.6j.1 | |||||||||
| Other_sequence (63) | |||||||||
| Associated_feature (30) | |||||||||
| Experimental_info | RNAi_result (15) | ||||||||
| Expr_pattern | Chronogram2041 | ||||||||
| Expr5094 | |||||||||
| Expr10566 | |||||||||
| Expr14240 | |||||||||
| Expr1016407 | |||||||||
| Expr1032617 | |||||||||
| Expr1143428 | |||||||||
| Expr2014444 | |||||||||
| Expr2032685 | |||||||||
| Drives_construct | WBCnstr00002115 | ||||||||
| WBCnstr00015626 | |||||||||
| WBCnstr00037907 | |||||||||
| WBCnstr00040674 | |||||||||
| Construct_product | WBCnstr00015626 | ||||||||
| WBCnstr00037907 | |||||||||
| Antibody | WBAntibody00002351 | ||||||||
| Microarray_results (59) | |||||||||
| Expression_cluster (227) | |||||||||
| Interaction (66) | |||||||||
| Map_info | Map | IV | Position | 4.05143 | Error | 0.000415 | |||
| Positive | Positive_clone | C01F6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| F23B2 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (12) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
