WormBase Tree Display for Gene: WBGene00006436
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WBGene00006436 | Evidence | CGC_data_submission | |||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | CHROMOSOME_V | ||||
Identity | Version | 4 | |||||
Name | CGC_name | ttn-1 | Person_evidence | WBPerson56 | |||
Sequence_name | W06H8.8 | ||||||
Molecular_name (43) | |||||||
Other_name | tag-7 | Curator_confirmed | WBPerson2970 | ||||
tag-211 | Curator_confirmed | WBPerson2970 | |||||
tag-58 | Person_evidence | WBPerson201 | |||||
Y38B5A.a | Curator_confirmed | WBPerson1983 | |||||
Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||
Y38B5A.b | Curator_confirmed | WBPerson1983 | |||||
Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||
CELE_W06H8.8 | Accession_evidence | NDB | BX284605 | ||||
Public_name | ttn-1 | ||||||
DB_info | Database (11) | ||||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (4) | ||||||
Acquires_merge | WBGene00006401 | ||||||
WBGene00021069 | |||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | ttn | ||||||
Allele (927) | |||||||
Strain | WBStrain00035550 | ||||||
WBStrain00035671 | |||||||
WBStrain00035980 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (25) | |||||||
Ortholog (28) | |||||||
Paralog (17) | |||||||
Structured_description | Concise_description | ttn-1, through multiple splicing, encodes at least six protein isoformsthat are orthologs of titin (OMIM:188840, mutated in cardiomyopathy ortibial muscular dystrophy), with the three largest isoforms being 2.2MDa, 1.2 MDa and 301 kDa; TTN-1 isoforms are expressed in body wall andvulval muscle, localized to the centers of I-bands, with the two largestisoforms expressed in all muscles except pharyngeal; the largest TTN-1isoform contains 56 Ig domains, 11 FnIII domains, a twitchin-likeprotein kinase domain, a domain similar to the elastic PEVK domain ofvertebrate titin, 96 tandem copies of a 16-residue motif predicted tocomprise a coiled-coil domain, and two other short multiply repeatedmotifs; the TTN-1 kinase domain is catalytically active, and itsactivity is quantitatively regulated by alternative splicing of anadjacent autoinhibitory domain; TTN-1 is mislocalized in analpha-actinin mutant (atn-1[ok84]); ttn-1 is transcribed from at leasttwo promoters, and its transcription is stimulated by NFI-1. | Paper_evidence | WBPaper00005546 | |||
WBPaper00006525 | |||||||
WBPaper00026912 | |||||||
WBPaper00027070 | |||||||
Curator_confirmed | WBPerson567 | ||||||
Date_last_updated | 18 Jan 2007 00:00:00 | ||||||
Automated_description | Enables actin filament binding activity and myosin binding activity. Predicted to be involved in phosphorylation. Located in A band and I band. Expressed in muscle cell. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS (14) | ||||||
Corresponding_CDS_history | W06H8.8a:wp262 | ||||||
W06H8.8b:wp262 | |||||||
W06H8.8d:wp262 | |||||||
W06H8.8e:wp262 | |||||||
W06H8.8f:wp262 | |||||||
W06H8.8g:wp262 | |||||||
Corresponding_transcript (15) | |||||||
Other_sequence (76) | |||||||
Associated_feature (48) | |||||||
Experimental_info | RNAi_result (15) | ||||||
Expr_pattern | Chronogram625 | ||||||
Expr2286 | |||||||
Expr6846 | |||||||
Expr9017 | |||||||
Expr1032615 | |||||||
Expr1158464 | |||||||
Expr2017574 | |||||||
Expr2035713 | |||||||
Drives_construct | WBCnstr00002629 | ||||||
Antibody | WBAntibody00000570 | ||||||
WBAntibody00000571 | |||||||
WBAntibody00002134 | |||||||
WBAntibody00002135 | |||||||
WBAntibody00002136 | |||||||
Microarray_results (80) | |||||||
Expression_cluster (261) | |||||||
Interaction (19) | |||||||
Map_info | Map | V | Position | -0.235725 | Error | 0.011128 | |
Positive | Positive_clone | W06H8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference (13) | |||||||
Remark | Gene name created from parsing 'genotype' field from CGC strain information | CGC_data_submission | |||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |