WormBase Tree Display for Gene: WBGene00006436
expand all nodes | collapse all nodes | view schema
WBGene00006436 | Evidence | CGC_data_submission | ||||
---|---|---|---|---|---|---|
SMap | S_parent | Sequence | CHROMOSOME_V | |||
Identity (6) | ||||||
Gene_info | Biotype | SO:0001217 | ||||
Gene_class | ttn | |||||
Allele (927) | ||||||
Strain | WBStrain00035550 | |||||
WBStrain00035671 | ||||||
WBStrain00035980 | ||||||
RNASeq_FPKM (74) | ||||||
GO_annotation (25) | ||||||
Ortholog (28) | ||||||
Paralog (17) | ||||||
Structured_description | Concise_description | ttn-1, through multiple splicing, encodes at least six protein isoformsthat are orthologs of titin (OMIM:188840, mutated in cardiomyopathy ortibial muscular dystrophy), with the three largest isoforms being 2.2MDa, 1.2 MDa and 301 kDa; TTN-1 isoforms are expressed in body wall andvulval muscle, localized to the centers of I-bands, with the two largestisoforms expressed in all muscles except pharyngeal; the largest TTN-1isoform contains 56 Ig domains, 11 FnIII domains, a twitchin-likeprotein kinase domain, a domain similar to the elastic PEVK domain ofvertebrate titin, 96 tandem copies of a 16-residue motif predicted tocomprise a coiled-coil domain, and two other short multiply repeatedmotifs; the TTN-1 kinase domain is catalytically active, and itsactivity is quantitatively regulated by alternative splicing of anadjacent autoinhibitory domain; TTN-1 is mislocalized in analpha-actinin mutant (atn-1[ok84]); ttn-1 is transcribed from at leasttwo promoters, and its transcription is stimulated by NFI-1. | Paper_evidence | WBPaper00005546 | ||
WBPaper00006525 | ||||||
WBPaper00026912 | ||||||
WBPaper00027070 | ||||||
Curator_confirmed | WBPerson567 | |||||
Date_last_updated | 18 Jan 2007 00:00:00 | |||||
Automated_description | Enables actin filament binding activity and myosin binding activity. Predicted to be involved in phosphorylation. Located in A band and I band. Expressed in muscle cell. | Paper_evidence | WBPaper00065943 | |||
Curator_confirmed | WBPerson324 | |||||
WBPerson37462 | ||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | |||||
Date_last_updated | 29 Nov 2023 00:00:00 | |||||
Molecular_info | Corresponding_CDS (14) | |||||
Corresponding_CDS_history | W06H8.8a:wp262 | |||||
W06H8.8b:wp262 | ||||||
W06H8.8d:wp262 | ||||||
W06H8.8e:wp262 | ||||||
W06H8.8f:wp262 | ||||||
W06H8.8g:wp262 | ||||||
Corresponding_transcript (15) | ||||||
Other_sequence (76) | ||||||
Associated_feature (48) | ||||||
Experimental_info | RNAi_result (15) | |||||
Expr_pattern | Chronogram625 | |||||
Expr2286 | ||||||
Expr6846 | ||||||
Expr9017 | ||||||
Expr1032615 | ||||||
Expr1158464 | ||||||
Expr2017574 | ||||||
Expr2035713 | ||||||
Drives_construct | WBCnstr00002629 | |||||
Antibody | WBAntibody00000570 | |||||
WBAntibody00000571 | ||||||
WBAntibody00002134 | ||||||
WBAntibody00002135 | ||||||
WBAntibody00002136 | ||||||
Microarray_results (80) | ||||||
Expression_cluster (261) | ||||||
Interaction (19) | ||||||
Map_info (3) | ||||||
Reference (13) | ||||||
Remark | Gene name created from parsing 'genotype' field from CGC strain information | CGC_data_submission | ||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |