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WormBase Tree Display for Gene: WBGene00006436

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Name Class

WBGene00006436EvidenceCGC_data_submission
SMapS_parentSequenceCHROMOSOME_V
IdentityVersion4
NameCGC_namettn-1Person_evidenceWBPerson56
Sequence_nameW06H8.8
Molecular_name (43)
Other_nametag-7Curator_confirmedWBPerson2970
tag-211Curator_confirmedWBPerson2970
tag-58Person_evidenceWBPerson201
Y38B5A.aCurator_confirmedWBPerson1983
RemarkOld cosmid naming mapped via unique overlapping PCR_product on CDSs
Y38B5A.bCurator_confirmedWBPerson1983
RemarkOld cosmid naming mapped via unique overlapping PCR_product on CDSs
CELE_W06H8.8Accession_evidenceNDBBX284605
Public_namettn-1
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:40WBPerson1971EventImportedInitial conversion from geneace
228 May 2004 14:21:37WBPerson1971EventAcquires_mergeWBGene00021069
307 Jul 2005 09:36:06WBPerson1983EventAcquires_mergeWBGene00006401
413 Dec 2005 14:47:30WBPerson2970Name_changeCGC_namettn-1
Other_nametag-58
Acquires_mergeWBGene00006401
WBGene00021069
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classttn
Allele (927)
StrainWBStrain00035550
WBStrain00035671
WBStrain00035980
RNASeq_FPKM (74)
GO_annotation (25)
Ortholog (28)
Paralog (17)
Structured_descriptionConcise_descriptionttn-1, through multiple splicing, encodes at least six protein isoformsthat are orthologs of titin (OMIM:188840, mutated in cardiomyopathy ortibial muscular dystrophy), with the three largest isoforms being 2.2MDa, 1.2 MDa and 301 kDa; TTN-1 isoforms are expressed in body wall andvulval muscle, localized to the centers of I-bands, with the two largestisoforms expressed in all muscles except pharyngeal; the largest TTN-1isoform contains 56 Ig domains, 11 FnIII domains, a twitchin-likeprotein kinase domain, a domain similar to the elastic PEVK domain ofvertebrate titin, 96 tandem copies of a 16-residue motif predicted tocomprise a coiled-coil domain, and two other short multiply repeatedmotifs; the TTN-1 kinase domain is catalytically active, and itsactivity is quantitatively regulated by alternative splicing of anadjacent autoinhibitory domain; TTN-1 is mislocalized in analpha-actinin mutant (atn-1[ok84]); ttn-1 is transcribed from at leasttwo promoters, and its transcription is stimulated by NFI-1.Paper_evidenceWBPaper00005546
WBPaper00006525
WBPaper00026912
WBPaper00027070
Curator_confirmedWBPerson567
Date_last_updated18 Jan 2007 00:00:00
Automated_descriptionEnables actin filament binding activity and myosin binding activity. Predicted to be involved in phosphorylation. Located in A band and I band. Expressed in muscle cell.Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDS (14)
Corresponding_CDS_historyW06H8.8a:wp262
W06H8.8b:wp262
W06H8.8d:wp262
W06H8.8e:wp262
W06H8.8f:wp262
W06H8.8g:wp262
Corresponding_transcript (15)
Other_sequence (76)
Associated_featureWBsf652683
WBsf652684
WBsf668998
WBsf668999
WBsf669000
WBsf669001
WBsf669002
WBsf669003
WBsf669004
WBsf669005
WBsf669006
WBsf669007
WBsf669008
WBsf669009
WBsf669010
WBsf669011
WBsf669012
WBsf716814
WBsf1000173
WBsf1000174
WBsf1000175
WBsf1000176
WBsf1000177
WBsf1000178
WBsf1000179
WBsf1000180
WBsf1000181
WBsf1000182
WBsf1000183
WBsf1000184
WBsf1000185
WBsf1019735
WBsf1019736
WBsf1019737
WBsf1019738
WBsf1019739
WBsf1019740
WBsf1019741
WBsf1019742
WBsf1019743
WBsf1019744
WBsf233765
WBsf233766
WBsf233767
WBsf233768
WBsf233769
WBsf233770
WBsf233771
Experimental_infoRNAi_result (15)
Expr_patternChronogram625
Expr2286
Expr6846
Expr9017
Expr1032615
Expr1158464
Expr2017574
Expr2035713
Drives_constructWBCnstr00002629
AntibodyWBAntibody00000570
WBAntibody00000571
WBAntibody00002134
WBAntibody00002135
WBAntibody00002136
Microarray_resultsSMD_F12F3.2
SMD_F12F3.3
SMD_H05O09.1
SMD_W06H8.C
SMD_Y38B5A.A
SMD_Y38B5A.B
174345_at
176443_s_at
183162_at
185778_at
187965_s_at
187994_at
A_12_P107291
A_12_P111600
A_12_P112244
A_12_P113565
A_12_P117028
A_12_P117825
A_12_P118962
A_12_P152016
A_12_P166564
Aff_F12F3.2
Aff_F12F3.3
Aff_H05O09.1
Aff_W06H8.C
GPL19516_CGZ0038668
GPL19516_CGZ0038669
GPL19516_CGZ0038670
GPL19516_CGZ0038671
GPL19516_CGZ0038672
GPL19516_CGZ0038673
GPL19516_CGZ0038674
GPL19516_CGZ0038675
GPL19516_CGZ0038676
GPL21109_W06H8.8a
GPL21109_W06H8.8c
GPL21109_W06H8.8d
GPL21109_W06H8.8e.1
GPL21109_W06H8.8g
GPL3518_CE25927
GPL3518_CE26070
GPL3518_CE27954
GPL3518_CE31088
GPL8673_W06H8_8aP00811
GPL8673_W06H8_8aP01355
GPL8673_W06H8_8aP01865
GPL8673_W06H8_8bP00811
GPL8673_W06H8_8bP01292
GPL8673_W06H8_8bP01802
GPL8673_W06H8_8cP09516
GPL8673_W06H8_8cP09538
GPL8673_W06H8_8cP09556
GPL8673_W06H8_8eP54365
GPL8673_W06H8_8eP55007
GPL8673_W06H8_8eP55334
GPL8673_W06H8_8fP54320
GPL8673_W06H8_8fP54962
GPL8673_W06H8_8fP55289
GPL8673_W06H8_8gP54364
GPL8673_W06H8_8gP55007
GPL8673_W06H8_8gP55546
GPL9450_F12F3.2a
GPL9450_F12F3.2b
GPL9450_F12F3.3
GPL9450_H05O09.1
GPL9450_W06H8.3
GPL9450_W06H8.8
GPL9450_Y38B5A.1
cea2.3.09497
cea2.3.17809
cea2.3.17814
cea2.3.17842
cea2.3.27795
cea2.d.07851
cea2.d.20256
cea2.i.45878
cea2.p.112879
cea2.p.119686
cea2.p.127053
cea2.p.127753
Expression_cluster (261)
Interaction (19)
Map_infoMapVPosition-0.235725Error0.011128
PositivePositive_cloneW06H8Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
Reference (13)
RemarkGene name created from parsing 'genotype' field from CGC strain informationCGC_data_submission
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene