Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.

WormBase Tree Display for Gene: WBGene00006424

expand all nodes | collapse all nodes | view schema

Name Class

WBGene00006424SMapS_parentSequenceF49E10
IdentityVersion3
NameCGC_namectbp-1Person_evidenceWBPerson2627
Sequence_nameF49E10.5
Molecular_nameF49E10.5a
F49E10.5a.1
CE29966
F49E10.5b
CE47412
F49E10.5b.1
Other_nametag-45Person_evidenceWBPerson201
CELE_F49E10.5Accession_evidenceNDBBX284606
Public_namectbp-1
DB_infoDatabaseAceViewgeneXG491
WormQTLgeneWBGene00006424
WormFluxgeneWBGene00006424
NDBlocus_tagCELE_F49E10.5
PanthergeneCAEEL|WormBase=WBGene00006424|UniProtKB=Q20595
familyPTHR46029
NCBIgene180853
RefSeqproteinNM_001270102.3
NM_001270101.4
SwissProtUniProtAccQ20595
UniProt_GCRPUniProtAccQ20595
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:40WBPerson1971EventImportedInitial conversion from geneace
205 Oct 2006 15:31:09WBPerson2970EventAcquires_mergeWBGene00018642
316 Oct 2006 14:08:57WBPerson2970Name_changeCGC_namectbp-1
Other_nametag-45
Acquires_mergeWBGene00018642
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classctbp
Allele (175)
Possibly_affected_byWBVar02157252
StrainWBStrain00031454
WBStrain00030103
WBStrain00047496
RNASeq_FPKM (74)
GO_annotation (15)
Ortholog (40)
ParalogWBGene00007836Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionProvisional_descriptiontag-45 encodes a D-isomer specific 2-hydroxyacid dehydrogenase.Curator_confirmedWBPerson48
Concise_descriptiontag-45 encodes a D-isomer specific 2-hydroxyacid dehydrogenase.
Automated_descriptionEnables RNA polymerase II-specific DNA-binding transcription factor binding activity and transcription corepressor activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in hypodermis and nervous system. Used to study alcohol use disorder. Is an ortholog of human CTBP1 (C-terminal binding protein 1) and CTBP2 (C-terminal binding protein 2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:1574Homo sapiensPaper_evidenceWBPaper00041098
Curator_confirmedWBPerson324
Date_last_updated21 May 2019 00:00:00
Models_disease_assertedWBDOannot00000674
Molecular_infoCorresponding_CDSF49E10.5a
F49E10.5b
Corresponding_transcriptF49E10.5a.1
F49E10.5b.1
Other_sequence (24)
Associated_feature (20)
Transcription_factorWBTranscriptionFactor000823
Experimental_infoRNAi_resultWBRNAi00015304Inferred_automaticallyRNAi_primary
WBRNAi00103373Inferred_automaticallyRNAi_primary
WBRNAi00047836Inferred_automaticallyRNAi_primary
WBRNAi00015305Inferred_automaticallyRNAi_primary
WBRNAi00047835Inferred_automaticallyRNAi_primary
Expr_patternExpr11825
Expr12091
Expr12092
Expr12541
Expr1025813
Expr1032609
Expr1151670
Expr2010565
Expr2028805
Drives_constructWBCnstr00019349
WBCnstr00020016
WBCnstr00021742
WBCnstr00042043
WBCnstr00042044
Construct_productWBCnstr00019349
WBCnstr00020016
WBCnstr00020017
WBCnstr00021150
WBCnstr00021742
Microarray_results (25)
Expression_clusterWBPaper00036375:enriched_in_PVD_OLL
WBPaper00037055:DAF-16_binding_DNA
WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
WBPaper00037950:all-neurons_L2-larva_expressed
WBPaper00037950:AVA-neuron_L1-larva_expressed
WBPaper00037950:AVE-neuron_L1-larva_expressed
WBPaper00037950:BAG-neuron_blastula-embryo_expressed
WBPaper00037950:bodywall-muscle_L1-larva_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
WBPaper00040209:B.thuringiensis_upregulated_MY15
WBPaper00044578:reduced-humidity_downregulated_microarray
WBPaper00044736:flat_dev_expression
WBPaper00045390:ubc-9(RNAi)_downregulated
WBPaper00046121:ecdoderm_unique
WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
WBPaper00047131:daf-2(e1370)_upregulated_N2-background
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_enriched
WBPaper00048988:neuron_expressed
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo
WBPaper00050344:AFD-neuron_enriched
WBPaper00050370:dpy-21(e428)_L3_upregulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
WBPaper00050990:body-muscle_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00051352:Long-Term-Association-Memory_upregulated
WBPaper00053184:sma-2(rax5)_upregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053295:lin-22(icb38)_upregulated
WBPaper00053295:lin-22(ot269)_upregulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053321:PGCs_depleted_NuGen
WBPaper00053388:dauer_regulated_Cluster3
WBPaper00054758:alg-1(gk204)_upregulated
WBPaper00055103:thoc-5(wy822)_upregulated
WBPaper00055354:Rapamycin-Allantoin_downregulated
WBPaper00055354:Rapamycin_downregulated
WBPaper00055354:Rifampicin_upregulated
WBPaper00055482:Tunicamycin_upregulated
WBPaper00055565:AVK_enriched
WBPaper00055827:pfd-6(gk493446)_downregulated
WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
WBPaper00056090:E.faecalis_upregulated_N2
WBPaper00056165:MINA-1_interacting_mRNA
WBPaper00056167:Cry5B_upregulated
WBPaper00056284:ints-1(RNAi)_downregulated
WBPaper00056284:ints-11(RNAi)_downregulated
WBPaper00056443:sek-1(km4)_upregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
WBPaper00056868:P.aeruginosa_upregulated_smallRNA
WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
WBPaper00057068:numr-1(RNAi)_downregulated
WBPaper00058598:mex-1(or286)_upregulated
WBPaper00058598:mex-3(eu149)_upregulated
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058598:spn-4(tm291)_upregulated
WBPaper00058691:cfp-1(tm6369)_downregulated
WBPaper00058969:RIS_enriched
WBPaper00059027:neuron-synapses_depleted
WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
WBPaper00059421:daf-1(m40);daf-3(mgDf90)_downregulated
WBPaper00059421:daf-3(mgDf90)_downregulated
WBPaper00059471:EGL-43_interacting
WBPaper00059763:neuron_expressed
WBPaper00060273:isp-1(qm150)_upregulated
WBPaper00060661:sensory-neuron_enriched
WBPaper00060811:L1_vs_adult_upregulated_neural
WBPaper00060909:atfs-1(cmh15)_downregulated
WBPaper00061203:let-418(n3536)_upregulated
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061340:AIA
WBPaper00061340:AIB
WBPaper00061340:AIM
WBPaper00061340:AIY
WBPaper00061340:AIZ
WBPaper00061340:ALN
WBPaper00061340:AVB
WBPaper00061340:AVD
WBPaper00061340:AVG
WBPaper00061340:AVH
WBPaper00061340:AVK
WBPaper00061340:AVL
WBPaper00061340:PLM
WBPaper00061340:PLM_ALN_grandparent
WBPaper00061340:RIA
WBPaper00061340:RIM
WBPaper00061340:SIA
WBPaper00061340:SIB
WBPaper00061340:SMB
WBPaper00061340:SMD
WBPaper00061340:URX
WBPaper00061341:28C_24h_upregulated
WBPaper00061341:28C_48h_upregulated
WBPaper00061479:hda-1(ne4752)_upregulated
WBPaper00061479:mep-1(ne4629)_upregulated
WBPaper00061527:C38C3.6-npr-7
WBPaper00061527:sol-1-jnk-1_18695
WBPaper00061527:sre-33-ZK1025.1_8337
WBPaper00061651:VC_4_5_enriched
WBPaper00061995:mter-4(syb3662syb3403)_downregulated
WBPaper00062103:neuron_enriched
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062193:skn-1(RNAi)_downregulated
WBPaper00062325:etr-1(lq61)_upregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062440:crh-1(n3315)_downregulated
WBPaper00062440:crh-1(syb385)_downregulated
WBPaper00062446:nhr-8(hd117)_upregulated
WBPaper00063930:BRD-1_interacting
WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064306:Agaro-oligosaccharides_upregulated
WBPaper00064661:lpd-3(ok2138)_upregulated
WBPaper00064716:paraquat_downregulated
WBPaper00064721:fasn-1(g14)_downregulated_starved
WBPaper00064871:hypoxia_downregulated_F2
WBPaper00065158:25C_vs_15C_upregulated_WholeAnimal
WBPaper00065581:hpk-1(pk1393)_upregulated
WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
WBPaper00065749:Heat-Shock_downregulated_N2
WBPaper00065841:14_2
WBPaper00065841:19_0
WBPaper00065841:68_0
WBPaper00065841:68_1
WBPaper00065841:93_0
WBPaper00065841:119_0
WBPaper00065841:122_0
WBPaper00065841:132_0
WBPaper00065841:145_0
WBPaper00066062:xrep-4(lax137)_upregulated
WBPaper00066110:tetraploid_vs_diploid_upregulated
cgc4489_group_5
cgc4489_group_14
WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
WBPaper00025032:cluster_187
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:Resveratrol_regulated_daf-16
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00027111:rrf-2(ok210)_upregulated
WBPaper00030839:Larval_Pan_Neuronal
WBPaper00031003:24hr_muscle_depleted
WBPaper00031003:total_muscle_depleted
WBPaper00031532:Larva_Pan_Neuronal_Enriched
WBPaper00031832:slr-2_regulated
WBPaper00034661:AgNPs_downregulated
WBPaper00035084:L3_enriched_AIN-2_IP
WBPaper00036130:mir-243_up_regulated
WBPaper00036286:Pattern_I
WBPaper00040858:eQTL_age_regulated_developing
WBPaper00040858:eQTL_regulated_developing
WBPaper00041174:environmental
WBPaper00041174:environmental_prime
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00045673:colistin_upregulated
WBPaper00045807:microcystin-LR_upregulated
WBPaper00046853:AOBr_M.aeruginosa-batch-culture_upregulated
WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO
WBPaper00057098:SiO2-nanoparticles_upregulated
[cgc6390]:Cluster_A
Interaction (71)
WBProcessWBbiopr:00000121
Map_infoMapXPosition-4.16195Error0.01114
PositivePositive_cloneF49E10Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
Reference (26)
RemarkKilled due to lack of dataCurator_confirmedWBPerson2970
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene