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WormBase Tree Display for Gene: WBGene00006410

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Name Class

WBGene00006410EvidenceCGC_data_submission
SMapS_parentSequenceZK470
IdentityVersion2
NameCGC_namenck-1Person_evidenceWBPerson103
Sequence_nameZK470.5
Molecular_nameZK470.5a
ZK470.5a.1
CE31270
ZK470.5b
CE53627
ZK470.5b.1
Other_nametag-22Person_evidenceWBPerson201
CELE_ZK470.5Accession_evidenceNDBBX284606
Public_namenck-1
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:40WBPerson1971EventImportedInitial conversion from geneace
224 Aug 2005 11:18:38WBPerson2970Name_changeCGC_namenck-1
Other_nametag-22
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classnck
Allele (104)
StrainWBStrain00002409
WBStrain00002332
WBStrain00031573
WBStrain00035589
RNASeq_FPKM (74)
GO_annotation00087952
00087953
00087954
00087955
00087956
00087957
00087958
00087959
00087960
Ortholog (44)
ParalogWBGene00004774Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionnck-1 encodes an SH2/SH3 domain-containing protein orthologous to the human NCK adaptor proteins that link tyrosine kinase signaling to actin cytoskeleton reorganization; in C. elegans, nck-1 activity is required for excretory canal migration and full axon migration in mechanosensory neurons; a nck-1::gfp promoter fusion is expressed in the excretory cell and ventral cord motorneurons.Paper_evidenceWBPaper00032514
Curator_confirmedWBPerson48
WBPerson1843
Date_last_updated21 Aug 2009 00:00:00
Automated_descriptionPredicted to enable receptor tyrosine kinase binding activity and signaling adaptor activity. Predicted to be involved in cell migration and signal transduction. Located in cytoplasm and nucleus. Expressed in several structures, including egg-laying apparatus; gonad; hypodermis; neuroblasts; and neurons. Is an ortholog of human NCK1 (NCK adaptor protein 1) and NCK2 (NCK adaptor protein 2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSZK470.5a
ZK470.5b
Corresponding_CDS_historyZK470.5b:wp272
Corresponding_transcriptZK470.5a.1
ZK470.5b.1
Other_sequence (15)
Associated_feature (19)
Experimental_infoRNAi_result (12)
Expr_pattern (18)
Drives_constructWBCnstr00002061
WBCnstr00003001
WBCnstr00004496
WBCnstr00013363
WBCnstr00013801
WBCnstr00013802
WBCnstr00013803
WBCnstr00014491
WBCnstr00034367
Construct_productWBCnstr00013802
WBCnstr00013803
WBCnstr00014490
WBCnstr00014491
WBCnstr00014494
WBCnstr00021621
WBCnstr00034367
AntibodyWBAntibody00002579
WBAntibody00003056
Microarray_results (31)
Expression_clusterWBPaper00029359_1197
WBPaper00029359_1225
WBPaper00029359_1291
WBPaper00029359_1367
WBPaper00029359_1483
WBPaper00029359_1494
WBPaper00029359_1546
WBPaper00029359_1561
WBPaper00029359_1582
WBPaper00029359_1655
WBPaper00032976:dosage_compensated_genes
WBPaper00033065:cyc-1(RNAi)_downregulated
WBPaper00035269:cde-1_regulated
WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
WBPaper00037950:all-neurons_L1-larva_expressed
WBPaper00037950:all-neurons_L2-larva_expressed
WBPaper00037950:bodywall-muscle_L2-larva_expressed
WBPaper00037950:coelomocytes_L2-larva_expressed
WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:excretory-cell_L2-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
WBPaper00037950:intestine_L2-larva_expressed
WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
WBPaper00040221:DAF-12_target_ALF4
WBPaper00044501:gld-1_let-7_regulated
WBPaper00044736:flat_dev_expression
WBPaper00045521:Oogenic
WBPaper00045974:NSM_enriched_totalRNA_RNAseq
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_expressed
WBPaper00049545:cco-1(RNAi)_upregulated
WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
WBPaper00050053:muscle_enriched_Day4
WBPaper00050370:dpy-21(e428)_L3_upregulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00051245:epidermis_cytoplasm_expressed
WBPaper00051245:intestine_cytoplasm_expressed
WBPaper00051245:intestine_nucleus_expressed
WBPaper00053184:sma-2(rax5)_upregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq
WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_embryo_SMARTseq
WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq
WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq
WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
WBPaper00053321:PGCs_depleted_NuGen
WBPaper00053388:dauer_regulated_Cluster3
WBPaper00053599:female_vs_male_upregulated
WBPaper00053599:mitosis_vs_meiosis_downregulated
WBPaper00053599:oocyte_vs_mitosis_downregulated
WBPaper00053615:SMO-1_target
WBPaper00055334:DLC-1_interacting
WBPaper00055354:Allantoin_upregulated
WBPaper00055482:pmt-2(RNAi)_upregulated
WBPaper00055804:FBF-1-FBF-2-associated_oogenic-enriched
WBPaper00055827:daf-2(e1370)_downregulated
WBPaper00056161:hermaphrodite_enriched_siRNA
WBPaper00056218:daf-16(mu86)_upregulated_Day7
WBPaper00056443:sek-1(km4)_upregulated
WBPaper00056471:S.aureus-4h_upregulated_N2
WBPaper00056826:hmc_biased
WBPaper00057288:Cold_downregulated_transcript
WBPaper00057288:iff-1(RNAi)_downregulated_transcript
WBPaper00058691:cfp-1(tm6369)_downregulated
WBPaper00059328:mrps-5(RNAi)_downregulated_protein
WBPaper00059471:EGL-43_interacting
WBPaper00059763:neuron_expressed
WBPaper00060811:L1_vs_adult_upregulated_neural
WBPaper00060909:atfs-1(cmh15)_downregulated
WBPaper00061527:uggt-1_21889-tag-320_20312
WBPaper00061527:utx-1_2886-swan-1_2192
WBPaper00061740:mir-1(gk276)_downregulated_protein
WBPaper00062325:etr-1(lq61)_upregulated
WBPaper00062669:extracellular-vesicle_protein
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064315:mes-3(bn199)_upregulated_EGCs
WBPaper00064315:mes-3(bn199)_upregulated_PGCs
WBPaper00064315:mes-4(bn73)_upregulated_EGCs
WBPaper00064315:mes-4(bn73)_upregulated_PGCs
WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
WBPaper00064716:paraquat_upregulated
WBPaper00065373:sek-1(km4)_downregulated_cisplatin
WBPaper00065835:Day11_vs_Day1_upregulated
WBPaper00065975:P-body_vs_oocyte_depleted
cgc4386_cluster_6_4
WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
WBPaper00025032:cluster_13
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00026980:intestine_enriched
WBPaper00030985:Serratia_marcesens_downregulated
WBPaper00034739:N2lessDR1350
WBPaper00035905:FBF-1_Associated
WBPaper00036123:Cadmium_regulated
WBPaper00040426:CYD-1_CDK-4_downregulated
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
WBPaper00040858:eQTL_age_regulated_aging
WBPaper00040858:eQTL_regulated_old
WBPaper00040963:Q100_down
WBPaper00040963:Q200_down
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_UVC-exposed_51h
WBPaper00041960:N2_fasting_upregulated_anytime
WBPaper00048989:N2_rapamycin_downregulated
WBPaper00050538:Fasting_upregulated
WBPaper00057098:SiO2-nanoparticles_upregulated
[cgc5767]:expression_class_E
[cgc5767]:expression_class_ET
[cgc5767]:expression_class_ET_max(53_min)
[cgc5767]:expression_class_E_pi(23_min)
[cgc5767]:expression_class_M
[cgc5767]:expression_class_ME
[cgc5767]:expression_class_MET
Interaction (107)
Map_infoMapXPosition-8.1368Error0.089595
PositivePositive_cloneZK470Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point4949
5017
Pseudo_map_position
Reference (21)
RemarkGene name created from parsing 'genotype' field from CGC strain informationCGC_data_submission
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene