WormBase Tree Display for Gene: WBGene00006318
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| WBGene00006318 | Evidence | Person_evidence | WBPerson655 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | F34D6 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | sup-9 | Person_evidence | WBPerson261 | |||||
| Sequence_name | F34D6.3 | ||||||||
| Molecular_name | F34D6.3 | ||||||||
| F34D6.3.1 | |||||||||
| CE28297 | |||||||||
| Other_name | twk-23 | Person_evidence | WBPerson655 | ||||||
| twk-38 | Person_evidence | WBPerson655 | |||||||
| CELE_F34D6.3 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | sup-9 | ||||||||
| DB_info | Database | AceView | gene | 2C976 | |||||
| WormQTL | gene | WBGene00006318 | |||||||
| WormFlux | gene | WBGene00006318 | |||||||
| NDB | locus_tag | CELE_F34D6.3 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006318|UniProtKB=O17185 | |||||||
| family | PTHR11003 | ||||||||
| NCBI | gene | 173613 | |||||||
| RefSeq | protein | NM_061932.6 | |||||||
| SwissProt | UniProtAcc | O17185 | |||||||
| UniProt_GCRP | UniProtAcc | O17185 | |||||||
| OMIM | gene | 603220 | |||||||
| 605874 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:40 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sup | ||||||||
| Allele (210) | |||||||||
| Legacy_information | n180 : recessive suppressor of unc-93(e1500) no phenotype alone; probably null allele. ES3 in presence of e1500 ME3. NA > 20 (n180spo n192uvi etc.; all resemble n180). | ||||||||
| See also n180, n186, n188, n189, n190, n191, n222, n223, n229, n233, n238, n241, n260, n261, n264, n266, n271, n345, n350, n353, n508, n514, n518, n519, n625, n634, n636, n659, n668, n1009, n1012, n1016, n1020, n1023, n1025, n1026, n1028, n1037, n1330 | |||||||||
| [Reiner D]] Mac-d (Muscle ACtivation-Defective) | |||||||||
| [C.elegansII] n180 : recessive suppressor of unc-93(e1500) no phenotype alone; probably null allele. ES3 in presence of e1500 ME3. OA>20(lf):n180spo, n192uvi, n186, n350 (all resemble n180). Also neomorphic dominant allele n1550sd(severe rubber-band, almost sterile, inviable;n1550/+ strong "rubber-band" Unc-93 phenotype. Muscle activation defective (flaccid, long)). Also dominant negative suppressor alleles n1435, n242 (semidominant suppressors of sup-10(n983). [Greenwald and Horvitz 1980, Levin & Horvitz 1993] | |||||||||
| Strain (11) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (21) | |||||||||
| Ortholog (38) | |||||||||
| Paralog (47) | |||||||||
| Structured_description | Concise_description | sup-9 encodes one of 44 C. elegans TWK (two-P domain K+) potassium channel subunits that contain two pore-forming domains and four transmembrane domains; sup-9 was originally defined by gain-of-function mutations that result in defects in pharyngeal, body-wall, egg-laying, and enteric muscle activation; loss of sup-9 function via reversion or RNA-mediated interference (RNAi) does not result in any abnormalities suggesting that SUP-9 may function redundantly with other TWK channels; SUP-9 is expressed in neurons and muscle. | Paper_evidence | WBPaper00002305 | |||||
| WBPaper00004644 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Involved in regulation of muscle contraction. Located in muscle cell projection membrane and striated muscle dense body. Expressed in body wall musculature; muscle cell; and neurons. Human ortholog(s) of this gene implicated in Birk-Barel syndrome and primary pulmonary hypertension. Is an ortholog of human KCNK3 (potassium two pore domain channel subfamily K member 3) and KCNK9 (potassium two pore domain channel subfamily K member 9). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:14557 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6278) | ||||
| DOID:0050675 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6283) | ||||||
| Molecular_info | Corresponding_CDS | F34D6.3 | |||||||
| Corresponding_transcript | F34D6.3.1 | ||||||||
| Other_sequence (14) | |||||||||
| Associated_feature | WBsf649937 | ||||||||
| WBsf987013 | |||||||||
| WBsf1011749 | |||||||||
| WBsf222784 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00027786 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00046256 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00014271 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00070646 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00103324 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00070647 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1378 | ||||||||
| Expr2772 | |||||||||
| Expr2775 | |||||||||
| Expr2776 | |||||||||
| Expr2777 | |||||||||
| Expr1010241 | |||||||||
| Expr1032552 | |||||||||
| Expr1150142 | |||||||||
| Expr2017133 | |||||||||
| Expr2035269 | |||||||||
| Drives_construct | WBCnstr00000319 | ||||||||
| WBCnstr00034398 | |||||||||
| Construct_product | WBCnstr00034398 | ||||||||
| Antibody | WBAntibody00000681 | ||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (114) | |||||||||
| Interaction (50) | |||||||||
| Map_info | Map | II | Position | -12.1433 | Error | 0.015949 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | nDf2 | |||||||
| nDf3 | |||||||||
| nDf4 | |||||||||
| nDf5 | |||||||||
| Positive_clone | F34D6 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| Mapping_data | 2_point | 404 | |||||||
| 784 | |||||||||
| 6131 | |||||||||
| 7115 | |||||||||
| Multi_point (12) | |||||||||
| Pos_neg_data | 454 | ||||||||
| 458 | |||||||||
| 460 | |||||||||
| 462 | |||||||||
| Landmark_gene | |||||||||
| Reference (57) | |||||||||
| Method | Gene |
