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WormBase Tree Display for Gene: WBGene00006318

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WBGene00006318	Evidence	Person_evidence	WBPerson655
	SMap	S_parent	Sequence	F34D6
	Identity	Version	1
		Name	CGC_name	sup-9	Person_evidence	WBPerson261
			Sequence_name	F34D6.3
			Molecular_name	F34D6.3
				F34D6.3.1
				CE28297
			Other_name	twk-23	Person_evidence	WBPerson655
				twk-38	Person_evidence	WBPerson655
				CELE_F34D6.3	Accession_evidence	NDB	BX284602
			Public_name	sup-9
		DB_info	Database	AceView	gene	2C976
				WormQTL	gene	WBGene00006318
				WormFlux	gene	WBGene00006318
				NDB	locus_tag	CELE_F34D6.3
				Panther	gene	CAEEL\|WormBase=WBGene00006318\|UniProtKB=O17185
					family	PTHR11003
				NCBI	gene	173613
				RefSeq	protein	NM_061932.6
				SwissProt	UniProtAcc	O17185
				UniProt_GCRP	UniProtAcc	O17185
				OMIM	gene	603220
						605874
		Species	Caenorhabditis elegans
		History	Version_change	1	07 Apr 2004 11:29:40	WBPerson1971	Event	Imported	Initial conversion from geneace
		Status	Live
	Gene_info	Biotype	SO:0001217
		Gene_class	sup
		Allele (210)
		Legacy_information	n180 : recessive suppressor of unc-93(e1500) no phenotype alone; probably null allele. ES3 in presence of e1500 ME3. NA > 20 (n180spo n192uvi etc.; all resemble n180).
			See also n180, n186, n188, n189, n190, n191, n222, n223, n229, n233, n238, n241, n260, n261, n264, n266, n271, n345, n350, n353, n508, n514, n518, n519, n625, n634, n636, n659, n668, n1009, n1012, n1016, n1020, n1023, n1025, n1026, n1028, n1037, n1330
			[Reiner D]] Mac-d (Muscle ACtivation-Defective)
			[C.elegansII] n180 : recessive suppressor of unc-93(e1500) no phenotype alone; probably null allele. ES3 in presence of e1500 ME3. OA>20(lf):n180spo, n192uvi, n186, n350 (all resemble n180). Also neomorphic dominant allele n1550sd(severe rubber-band, almost sterile, inviable;n1550/+ strong "rubber-band" Unc-93 phenotype. Muscle activation defective (flaccid, long)). Also dominant negative suppressor alleles n1435, n242 (semidominant suppressors of sup-10(n983). [Greenwald and Horvitz 1980, Levin & Horvitz 1993]
		Strain (11)
		RNASeq_FPKM (74)
		GO_annotation (21)
		Ortholog	WBGene00054624	Caenorhabditis remanei	From_analysis	OMA
						TreeFam
						Inparanoid_8
						WormBase-Compara
			WBGene00038758	Caenorhabditis briggsae	From_analysis	OrthoMCL
						OMA
						Inparanoid_8
						WormBase-Compara
			WBGene00161597	Caenorhabditis brenneri	From_analysis	TreeFam
						WormBase-Compara
			WBGene00157415	Caenorhabditis brenneri	From_analysis	OMA
						TreeFam
						Inparanoid_8
						WormBase-Compara
			WBGene00129583	Caenorhabditis japonica	From_analysis	TreeFam
						Inparanoid_8
						WormBase-Compara
			WBGene00117717	Pristionchus pacificus	From_analysis	Inparanoid_8
			CSP26.g5003	Caenorhabditis zanzibari	From_analysis	WormBase-Compara
			CSP28.g19511	Caenorhabditis panamensis	From_analysis	WormBase-Compara
			CSP29.g21343	Caenorhabditis becei	From_analysis	WormBase-Compara
			CSP32.g11078	Caenorhabditis sulstoni	From_analysis	WormBase-Compara
			CSP39.g21736	Caenorhabditis waitukubuli	From_analysis	WormBase-Compara
			CSP40.g3234	Caenorhabditis tribulationis	From_analysis	WormBase-Compara
			Cnig_chr_II.g6988	Caenorhabditis nigoni	From_analysis	WormBase-Compara
			Csp11.Scaffold629.g9997	Caenorhabditis tropicalis	From_analysis	WormBase-Compara
			Csp5_scaffold_00304.g9061	Caenorhabditis sinica	From_analysis	WormBase-Compara
			GCK72_006819	Caenorhabditis remanei	From_analysis	WormBase-Compara
			Pan_g2233	Panagrellus redivivus	From_analysis	WormBase-Compara
			Sp34_20041300	Caenorhabditis inopinata	From_analysis	WormBase-Compara
			chrII_pilon.g3751	Caenorhabditis elegans	From_analysis	WormBase-Compara
			WBGene00239393	Onchocerca volvulus	From_analysis	WormBase-Compara
			WBGene00259142	Strongyloides ratti	From_analysis	WormBase-Compara
			WBGene00290219	Trichuris muris	From_analysis	WormBase-Compara
			WBGene00301845	Trichuris muris	From_analysis	WormBase-Compara
			FB:FBgn0037690	Drosophila melanogaster	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OMA
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
			FB:FBgn0038165	Drosophila melanogaster	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OMA
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			ZFIN:ZDB-GENE-040724-171	Danio rerio	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OMA
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			ZFIN:ZDB-GENE-120709-43	Danio rerio	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OMA
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			ZFIN:ZDB-GENE-070705-260	Danio rerio	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			ZFIN:ZDB-GENE-080220-30	Danio rerio	From_analysis	Hieranoid
						Inparanoid
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			HGNC:6278	Homo sapiens	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OMA
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			HGNC:6283	Homo sapiens	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OMA
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			HGNC:13814	Homo sapiens	From_analysis	Hieranoid
						OrthoFinder
						Panther
						PhylomeDB
			MGI:1100509	Mus musculus	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OMA
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			MGI:3521816	Mus musculus	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OMA
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			MGI:2675209	Mus musculus	From_analysis	Hieranoid
						Inparanoid
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			RGD:61997	Rattus norvegicus	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			RGD:621451	Rattus norvegicus	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OMA
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			RGD:619733	Rattus norvegicus	From_analysis	Hieranoid
						Inparanoid
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
		Paralog (47)
		Structured_description	Concise_description	sup-9 encodes one of 44 C. elegans TWK (two-P domain K+) potassium channel subunits that contain two pore-forming domains and four transmembrane domains; sup-9 was originally defined by gain-of-function mutations that result in defects in pharyngeal, body-wall, egg-laying, and enteric muscle activation; loss of sup-9 function via reversion or RNA-mediated interference (RNAi) does not result in any abnormalities suggesting that SUP-9 may function redundantly with other TWK channels; SUP-9 is expressed in neurons and muscle.	Paper_evidence	WBPaper00002305
						WBPaper00004644
					Curator_confirmed	WBPerson1843
					Date_last_updated	17 Jun 2004 00:00:00
			Automated_description	Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Involved in regulation of muscle contraction. Located in muscle cell projection membrane and striated muscle dense body. Expressed in body wall musculature; muscle cell; and neurons. Human ortholog(s) of this gene implicated in Birk-Barel syndrome and primary pulmonary hypertension. Is an ortholog of human KCNK3 (potassium two pore domain channel subfamily K member 3) and KCNK9 (potassium two pore domain channel subfamily K member 9).	Paper_evidence	WBPaper00065943
					Curator_confirmed	WBPerson324
						WBPerson37462
					Inferred_automatically	This description was generated automatically by a script based on data from the WS291 version of WormBase
					Date_last_updated	29 Nov 2023 00:00:00
	Disease_info	Potential_model	DOID:14557	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:6278)
			DOID:0050675	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:6283)
	Molecular_info	Corresponding_CDS	F34D6.3
		Corresponding_transcript	F34D6.3.1
		Other_sequence (14)
		Associated_feature	WBsf649937
			WBsf987013
			WBsf1011749
			WBsf222784
	Experimental_info	RNAi_result	WBRNAi00027786	Inferred_automatically	RNAi_primary
			WBRNAi00046256	Inferred_automatically	RNAi_primary
			WBRNAi00014271	Inferred_automatically	RNAi_primary
			WBRNAi00070646	Inferred_automatically	RNAi_primary
			WBRNAi00103324	Inferred_automatically	RNAi_primary
			WBRNAi00070647	Inferred_automatically	RNAi_primary
		Expr_pattern	Expr1378
			Expr2772
			Expr2775
			Expr2776
			Expr2777
			Expr1010241
			Expr1032552
			Expr1150142
			Expr2017133
			Expr2035269
		Drives_construct	WBCnstr00000319
			WBCnstr00034398
		Construct_product	WBCnstr00034398
		Antibody	WBAntibody00000681
		Microarray_results (18)
		Expression_cluster (114)
		Interaction (50)
	Map_info	Map	II	Position	-12.1433	Error	0.015949
		Well_ordered
		Positive	Inside_rearr	nDf2
				nDf3
				nDf4
				nDf5
			Positive_clone	F34D6	Inferred_automatically	From sequence, transcript, pseudogene data
		Mapping_data	2_point	404
				784
				6131
				7115
			Multi_point (12)
			Pos_neg_data	454
				458
				460
				462
		Landmark_gene
	Reference (57)
	Method	Gene