WormBase Tree Display for Gene: WBGene00005022
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| WBGene00005022 | SMap | S_parent | Sequence | F29F11 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | sqv-4 | Person_evidence | WBPerson268 | |||||
| Sequence_name | F29F11.1 | ||||||||
| Molecular_name | F29F11.1 | ||||||||
| F29F11.1.1 | |||||||||
| CE05767 | |||||||||
| Other_name | CELE_F29F11.1 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | sqv-4 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:37 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sqv | ||||||||
| Allele (28) | |||||||||
| Legacy_information | [Herman T] sqv for squashed vulva. morphology of L4 vulva abnormal (invagination considerably reduced). hermaphrodites self-sterile | ||||||||
| [C.elegansII] n2840 : morphology of L4 vulva abnormal (invagination considerably reduced); hermaphrodites self-sterile OA1: n2827. [MT] | |||||||||
| Complementation_data | [Herman T] complements spe-10(hc104ts) | ||||||||
| Strain | WBStrain00027355 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (20) | |||||||||
| Ortholog (41) | |||||||||
| Structured_description | Concise_description | sqv-4 encodes a UDP-glucose 6-dehydrogenase, biochemically active in vitro, that is required for cytokinesis of one-cell embryos and for vulval morphogenesis; SQV-4 is orthologous to Drosophila SUGARLESS, human UGDH (OMIM:603370), and zebrafish JEKYLL; SQV-4 is expressed in many cell types, notably oocytes and uterine, seam, pharyngeal, and spermathecal cells, with expression being prominent in 14 of the 22 vulval nuclei of late L4 larvae; the common requirement for SQV-4 in both cytokinesis and morphogenesis may be to promote filling an extracellular space with hygroscopic proteoglycans (either in the eggshell, or underneath the L4 cuticle), which in turn may cause the space to fill with fluid. | Paper_evidence | WBPaper00005541 | |||||
| WBPaper00012891 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables UDP-glucose 6-dehydrogenase activity and identical protein binding activity. Involved in several processes, including egg-laying behavior; glycosaminoglycan biosynthetic process; and vulval development. Located in cytoplasm. Expressed in several structures, including germ line; hermaphrodite gonad; hypodermis; oocyte; and vulva. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 84. Is an ortholog of human UGDH (UDP-glucose 6-dehydrogenase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0112219 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12525) | ||||
| Molecular_info | Corresponding_CDS | F29F11.1 | |||||||
| Corresponding_transcript | F29F11.1.1 | ||||||||
| Other_sequence (45) | |||||||||
| Associated_feature | WBsf653019 | ||||||||
| WBsf669320 | |||||||||
| WBsf977266 | |||||||||
| WBsf977267 | |||||||||
| WBsf977268 | |||||||||
| WBsf1001159 | |||||||||
| WBsf1020330 | |||||||||
| WBsf234425 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00085637 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00031580 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00008724 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00045929 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00025315 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr2291 | ||||||||
| Expr2292 | |||||||||
| Expr3229 | |||||||||
| Expr4150 | |||||||||
| Expr1018017 | |||||||||
| Expr1032505 | |||||||||
| Expr1149829 | |||||||||
| Expr2016122 | |||||||||
| Expr2034357 | |||||||||
| Drives_construct | WBCnstr00010754 | ||||||||
| Construct_product | WBCnstr00010754 | ||||||||
| Antibody | WBAntibody00000568 | ||||||||
| Microarray_results (23) | |||||||||
| Expression_cluster (188) | |||||||||
| Interaction (114) | |||||||||
| Map_info | Map | V | Position | 2.7064 | Error | 0.002471 | |||
| Positive | Positive_clone | F29F11 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 3141 | |||||||
| 3142 | |||||||||
| 4882 | |||||||||
| Reference (23) | |||||||||
| Method | Gene |
