WormBase Tree Display for Gene: WBGene00005022

WBGene00005022 SMap: S_parent: Sequence: F29F11
  Identity: Version: 1
    Name: CGC_name: sqv-4 Person_evidence: WBPerson268
      Sequence_name: F29F11.1
      Molecular_name: F29F11.1
        F29F11.1.1
        CE05767
      Other_name: CELE_F29F11.1 Accession_evidence: NDB BX284605
      Public_name: sqv-4
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:37 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: sqv
    Allele (28)
    Legacy_information: [Herman T] sqv for squashed vulva. morphology of L4 vulva abnormal (invagination considerably reduced). hermaphrodites self-sterile
      [C.elegansII] n2840 : morphology of L4 vulva abnormal (invagination considerably reduced); hermaphrodites self-sterile OA1: n2827. [MT]
    Complementation_data: [Herman T] complements spe-10(hc104ts)
    Strain: WBStrain00027355
    RNASeq_FPKM (74)
    GO_annotation (20)
    Ortholog (41)
    Structured_description: Concise_description: sqv-4 encodes a UDP-glucose 6-dehydrogenase, biochemically active in vitro, that is required for cytokinesis of one-cell embryos and for vulval morphogenesis; SQV-4 is orthologous to Drosophila SUGARLESS, human UGDH (OMIM:603370), and zebrafish JEKYLL; SQV-4 is expressed in many cell types, notably oocytes and uterine, seam, pharyngeal, and spermathecal cells, with expression being prominent in 14 of the 22 vulval nuclei of late L4 larvae; the common requirement for SQV-4 in both cytokinesis and morphogenesis may be to promote filling an extracellular space with hygroscopic proteoglycans (either in the eggshell, or underneath the L4 cuticle), which in turn may cause the space to fill with fluid. Paper_evidence: WBPaper00005541
            WBPaper00012891
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables UDP-glucose 6-dehydrogenase activity and identical protein binding activity. Involved in several processes, including egg-laying behavior; glycosaminoglycan biosynthetic process; and vulval development. Located in cytoplasm. Expressed in several structures, including germ line; hermaphrodite gonad; hypodermis; oocyte; and vulva. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 84. Is an ortholog of human UGDH (UDP-glucose 6-dehydrogenase). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0112219 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12525)
  Molecular_info: Corresponding_CDS: F29F11.1
    Corresponding_transcript: F29F11.1.1
    Other_sequence (45)
    Associated_feature: WBsf653019
      WBsf669320
      WBsf977266
      WBsf977267
      WBsf977268
      WBsf1001159
      WBsf1020330
      WBsf234425
  Experimental_info: RNAi_result: WBRNAi00085637 Inferred_automatically: RNAi_primary
      WBRNAi00031580 Inferred_automatically: RNAi_primary
      WBRNAi00008724 Inferred_automatically: RNAi_primary
      WBRNAi00045929 Inferred_automatically: RNAi_primary
      WBRNAi00025315 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr2291
      Expr2292
      Expr3229
      Expr4150
      Expr1018017
      Expr1032505
      Expr1149829
      Expr2016122
      Expr2034357
    Drives_construct: WBCnstr00010754
    Construct_product: WBCnstr00010754
    Antibody: WBAntibody00000568
    Microarray_results (23)
    Expression_cluster (188)
    Interaction: WBInteraction000029254
      WBInteraction000029255
      WBInteraction000029260
      WBInteraction000033559
      WBInteraction000035056
      WBInteraction000035057
      WBInteraction000035602
      WBInteraction000035603
      WBInteraction000035742
      WBInteraction000039621
      WBInteraction000039976
      WBInteraction000041350
      WBInteraction000041882
      WBInteraction000045102
      WBInteraction000046496
      WBInteraction000047227
      WBInteraction000047576
      WBInteraction000048546
      WBInteraction000048892
      WBInteraction000049041
      WBInteraction000049101
      WBInteraction000155136
      WBInteraction000228255
      WBInteraction000297992
      WBInteraction000316985
      WBInteraction000336604
      WBInteraction000414620
      WBInteraction000473432
      WBInteraction000506753
      WBInteraction000506754
      WBInteraction000506755
      WBInteraction000506756
      WBInteraction000506757
      WBInteraction000506758
      WBInteraction000506759
      WBInteraction000506760
      WBInteraction000506761
      WBInteraction000506762
      WBInteraction000506763
      WBInteraction000506764
      WBInteraction000506765
      WBInteraction000506766
      WBInteraction000506767
      WBInteraction000506768
      WBInteraction000506769
      WBInteraction000506770
      WBInteraction000506771
      WBInteraction000506772
      WBInteraction000506773
      WBInteraction000506774
      WBInteraction000506775
      WBInteraction000506776
      WBInteraction000506777
      WBInteraction000506778
      WBInteraction000506779
      WBInteraction000506780
      WBInteraction000506781
      WBInteraction000506782
      WBInteraction000506783
      WBInteraction000506784
      WBInteraction000506785
      WBInteraction000506786
      WBInteraction000506787
      WBInteraction000506788
      WBInteraction000506789
      WBInteraction000506790
      WBInteraction000506791
      WBInteraction000506792
      WBInteraction000506793
      WBInteraction000506848
      WBInteraction000506849
      WBInteraction000506850
      WBInteraction000506851
      WBInteraction000506852
      WBInteraction000506853
      WBInteraction000506854
      WBInteraction000512530
      WBInteraction000512531
      WBInteraction000512532
      WBInteraction000512533
      WBInteraction000512534
      WBInteraction000521474
      WBInteraction000523217
      WBInteraction000523344
      WBInteraction000523519
      WBInteraction000540411
      WBInteraction000543630
      WBInteraction000544280
      WBInteraction000545871
      WBInteraction000546125
      WBInteraction000546194
      WBInteraction000546222
      WBInteraction000546392
      WBInteraction000546454
      WBInteraction000546522
      WBInteraction000546671
      WBInteraction000546782
      WBInteraction000546876
      WBInteraction000547939
      WBInteraction000547940
      WBInteraction000551649
      WBInteraction000554320
      WBInteraction000557839
      WBInteraction000564805
      WBInteraction000565587
      WBInteraction000565588
      WBInteraction000573588
      WBInteraction000577057
      WBInteraction000577210
      WBInteraction000577338
      WBInteraction000578598
      WBInteraction000579609
      WBInteraction000582811
      WBInteraction000583129
  Map_info: Map: V Position: 2.7064 Error: 0.002471
    Positive: Positive_clone: F29F11 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 3141
        3142
        4882
  Reference (23)
  Method: Gene