WormBase Tree Display for Gene: WBGene00004978
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| WBGene00004978 | SMap | S_parent | Sequence | Y47G6A | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | spg-7 | Person_evidence | WBPerson530 | |||||
| Sequence_name | Y47G6A.10 | ||||||||
| Molecular_name | Y47G6A.10 | ||||||||
| Y47G6A.10.1 | |||||||||
| CE34400 | |||||||||
| Other_name | phi-23 | Person_evidence | WBPerson2582 | ||||||
| let-517 | Person_evidence | WBPerson533 | |||||||
| Y47G6A_247.g | Curator_confirmed | WBPerson1983 | |||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| CELE_Y47G6A.10 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | spg-7 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:37 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 17 Mar 2005 13:54:35 | WBPerson2970 | Name_change | Other_name | phi-23 | ||||
| 3 | 05 Mar 2015 09:01:29 | WBPerson2970 | Event | Acquires_merge | WBGene00002708 | ||||
| Name_change | Other_name | let-517 | |||||||
| Acquires_merge | WBGene00002708 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | spg | ||||||||
| Allele (228) | |||||||||
| Legacy_information | [C.elegansII] h264 : lethal. OA2: h757, h1398. [KR] | ||||||||
| Strain | WBStrain00023743 | ||||||||
| WBStrain00005598 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (46) | |||||||||
| Contained_in_operon | CEOP1969 | ||||||||
| Ortholog (41) | |||||||||
| Paralog | WBGene00010842 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00015208 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00021425 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00021615 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | spg-7 encodes a metalloprotease orthologous to human paraplegin, a nuclear-encoded mitochondrial metalloprotease mutations in which are associated with hereditary spastic paraplegia (spinal cord dysfunction); based upon studies of Saccharomyces cerevisiae SPG7, C. elegans SPG-7 is predicted to function as part of a mt-AAA metalloprotease that regulates proteolytic degradation of mitochondrial proteins and formation of multisubunit mitochondrial protein complexes; loss of spg-7 activity via large-scale RNAi indicates that SPG-7 function is required for embryonic and larval development, reproduction, normal body size and growth rates, and proper subcellular localization of an unc-54::POLYQ(Q35)-YFP transgene; in addition, postdevelopmental inactivation of spg-7 results in significantly increased adult lifespan. | Paper_evidence | WBPaper00004402 | |||||
| WBPaper00004651 | |||||||||
| WBPaper00006395 | |||||||||
| WBPaper00006510 | |||||||||
| WBPaper00024269 | |||||||||
| WBPaper00024497 | |||||||||
| WBPaper00025054 | |||||||||
| WBPaper00029254 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 11 Oct 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable metalloendopeptidase activity. Involved in several processes, including mitochondrial protein processing; positive regulation of nematode male tail tip morphogenesis; and regulation of gene expression. Predicted to be located in mitochondrion. Predicted to be part of m-AAA complex. Expressed in germ line. Human ortholog(s) of this gene implicated in optic atrophy 12; spastic ataxia 5; and spinocerebellar ataxia type 28. Is an ortholog of human AFG3L2 (AFG3 like matrix AAA peptidase subunit 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0050977 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:315) | ||||
| DOID:0050952 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:315) | ||||||
| DOID:0050944 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:315) | ||||||
| DOID:0080840 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:315) | ||||||
| Molecular_info | Corresponding_CDS | Y47G6A.10 | |||||||
| Corresponding_CDS_history | Y47G6A.10:wp102 | ||||||||
| Corresponding_transcript | Y47G6A.10.1 | ||||||||
| Other_sequence (66) | |||||||||
| Associated_feature (11) | |||||||||
| Experimental_info | RNAi_result (117) | ||||||||
| Expr_pattern | Expr4061 | ||||||||
| Expr1015221 | |||||||||
| Expr1032476 | |||||||||
| Expr1160254 | |||||||||
| Expr2016053 | |||||||||
| Expr2034288 | |||||||||
| Regulate_expr_cluster | WBPaper00041370:spg-7(RNAi)_upregulated | ||||||||
| WBPaper00041370:spg-7(RNAi)_upregulated_atfs-1_dependent | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (117) | |||||||||
| Interaction (149) | |||||||||
| WBProcess | WBbiopr:00000077 | ||||||||
| WBbiopr:00000079 | |||||||||
| Map_info | Map | I | Position | -3.21963 | Error | 0.03887 | |||
| Hide_under | WBGene00002709 | ||||||||
| Positive | Positive_clone | Y47G6A | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Negative | Outside_rearr | hDf24 | |||||||
| Mapping_data | Multi_point | 5016 | |||||||
| Pos_neg_data | 8616 | ||||||||
| 8617 | |||||||||
| 8618 | |||||||||
| 8619 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (41) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
