WormBase Tree Display for Gene: WBGene00004889

WBGene00004889 SMap: S_parent: Sequence: Y54E5B
  Identity: Version: 1
    Name: CGC_name: smp-1 Person_evidence: WBPerson893
      Sequence_name: Y54E5B.1
      Molecular_name (12)
      Other_name: cesema Accession_evidence: EMBL U15667
        CELE_Y54E5B.1 Accession_evidence: NDB BX284601
      Public_name: smp-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:36 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: smp
    Allele: WBVar01915627
      WBVar00694099
      WBVar01915628
      WBVar00694100
      WBVar00694101
      WBVar01915629
      WBVar00694102
      WBVar01915630
      WBVar00694103
      WBVar00694104
      WBVar01357323
      WBVar00694105
      WBVar00694106
      WBVar00301657
      WBVar00694107
      WBVar01435082
      WBVar00694108
      WBVar01435083
      WBVar00309677
      WBVar00694109
      WBVar01357334
      WBVar01357345
      WBVar02108094
      WBVar00694110
      WBVar00694111
      WBVar00694112
      WBVar01357356
      WBVar00694113
      WBVar00694114
      WBVar00694115
      WBVar00694116
      WBVar00694117
      WBVar00694118
      WBVar00694119
      WBVar00694120
      WBVar00694121
      WBVar01476721
      WBVar00694122
      WBVar01476722
      WBVar01499908
      WBVar00694123
      WBVar00162558
      WBVar00694124
      WBVar00162559
      WBVar00694125
      WBVar00162560
      WBVar00694126
      WBVar00162561
      WBVar01557758
      WBVar00694127
      WBVar00162562
      WBVar01557759
      WBVar00162563
      WBVar00694128
      WBVar00162564
      WBVar00694129
      WBVar00162565
      WBVar00694130
      WBVar00162566
      WBVar00543274
      WBVar00694131
      WBVar00694132
      WBVar00694133
      WBVar00694134
      WBVar00694135
      WBVar00694136
      WBVar00694137
      WBVar01499739
      WBVar00694138
      WBVar01231835
      WBVar01231838
      WBVar01231839
      WBVar02017105
      WBVar02017106
      WBVar02017107
      WBVar02129126
      WBVar02129127
      WBVar00253448
      WBVar01290524
      WBVar01290525
      WBVar01236418
      WBVar01494436
      WBVar01236429
      WBVar01236440
      WBVar00353298
      WBVar00353299
      WBVar00353300
      WBVar00353301
      WBVar00353302
      WBVar00353303
      WBVar00353304
      WBVar00353305
      WBVar00353306
      WBVar00353307
      WBVar00353308
      WBVar00353309
      WBVar01502733
      WBVar00353310
      WBVar01502734
      WBVar01502735
      WBVar00353311
      WBVar00353312
      WBVar00353313
      WBVar02046964
      WBVar01622962
      WBVar00247584
      WBVar00051912
      WBVar00145275
      WBVar00145277
      WBVar01993819
      WBVar01499627
      WBVar01499628
      WBVar01499999
      WBVar02144950
      WBVar01499823
      WBVar00142393
      WBVar01499298
      WBVar02039782
      WBVar01498939
      WBVar01948647
      WBVar01412330
      WBVar00694079
      WBVar00694080
      WBVar00694081
      WBVar00694082
      WBVar00694083
      WBVar00694084
      WBVar00694085
      WBVar00694086
      WBVar00694087
      WBVar00694088
      WBVar00694089
      WBVar00694090
      WBVar00694091
      WBVar00694092
      WBVar00694093
      WBVar00694094
      WBVar00694095
      WBVar01915623
      WBVar00694096
      WBVar00694097
      WBVar01915624
      WBVar00694098
      WBVar01915626
    Strain: WBStrain00029151
    RNASeq_FPKM (74)
    GO_annotation (16)
    Ortholog (102)
    Paralog: WBGene00003111 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00004890 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00009094 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: smp-1 encodes a semaphorin; smp-1 activity is required for vulval morphogenesis, specifically for the movement of homologous pairs of vulval cells towards the vulval midline prior to cell fusion; smp-1 expression in vulval cells is regulated by the VAB-23 zinc-finger domain protein which binds smp-1 regulatory sequence in vivo. Paper_evidence: WBPaper00040292
            WBPaper00025151
          Curator_confirmed: WBPerson1843
          Date_last_updated: 13 Oct 2011 00:00:00
      Automated_description: Enables semaphorin receptor binding activity. Involved in nematode male tail mating organ morphogenesis. Predicted to be located in membrane. Expressed in several structures, including hermaphrodite distal tip cell; non-striated muscle; ray; somatic nervous system; and vulval cell. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 16 with or without anosmia; progressive myoclonus epilepsy; and rheumatoid arthritis. Is an ortholog of several human genes including SEMA3B (semaphorin 3B); SEMA3C (semaphorin 3C); and SEMA6C (semaphorin 6C). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:7148 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10725)
      DOID:0090080 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10723)
      DOID:891 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10739)
  Molecular_info: Corresponding_CDS: Y54E5B.1a
      Y54E5B.1b
      Y54E5B.1c
    Corresponding_transcript: Y54E5B.1a.1
      Y54E5B.1b.1
      Y54E5B.1b.2
      Y54E5B.1b.3
      Y54E5B.1b.4
      Y54E5B.1c.1
    Other_sequence (24)
    Associated_feature (24)
  Experimental_info: RNAi_result: WBRNAi00065917 Inferred_automatically: RNAi_primary
      WBRNAi00022980 Inferred_automatically: RNAi_primary
      WBRNAi00022981 Inferred_automatically: RNAi_primary
      WBRNAi00116872 Inferred_automatically: RNAi_primary
      WBRNAi00057388 Inferred_automatically: RNAi_primary
      WBRNAi00004745 Inferred_automatically: RNAi_primary
      WBRNAi00091930 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1885
      Expr3276
      Expr9188
      Expr1026364
      Expr1032428
      Expr1160822
      Expr2015922
      Expr2034155
    Drives_construct (15)
    Construct_product (20)
    Microarray_results (27)
    Expression_cluster (129)
    Interaction (45)
    Anatomy_function: WBbtf0686
      WBbtf0687
      WBbtf0688
      WBbtf0689
      WBbtf0690
      WBbtf0691
      WBbtf1066
  Map_info: Map: I Position: 27.3982 Error: 0.247471
    Positive: Positive_clone: Y54E5B Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4669
    Pseudo_map_position
  Reference (35)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene