WormBase Tree Display for Gene: WBGene00004875
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| WBGene00004875 | SMap | S_parent | Sequence | CHROMOSOME_I | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | smd-1 | |||||||
| Sequence_name | F47G4.7 | ||||||||
| Molecular_name | F47G4.7 | ||||||||
| F47G4.7.1 | |||||||||
| CE18705 | |||||||||
| F47G4.7.2 | |||||||||
| F47G4.7.3 | |||||||||
| Other_name | samdc | Accession_evidence | EMBL | Y12499 | |||||
| Y12500 | |||||||||
| CELE_F47G4.7 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | smd-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 02 Mar 2018 10:40:21 | WBPerson4025 | Event | Split_into | WBGene00303058 | ||||
| Split_into | WBGene00303058 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | smd | ||||||||
| Allele (68) | |||||||||
| Strain | WBStrain00032658 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (16) | |||||||||
| Contained_in_operon | CEOP1730 | ||||||||
| Ortholog (40) | |||||||||
| Structured_description | Concise_description | smd-1 encodes an S-adenosylmethionine decarboxylase; SMD-1 functions in polyamine biosynthesis, exhibiting adenosylmethionine decarboxylase activity in vitro that is stimulated by putrescine; in large-scale RNAi screens, loss of smd-1 results in defective axon guidance and, in a sensitized genetic background, locomotion defects; smd-1::gfp reporter fusions are expressed in the intestine and in head and tail neurons; in males, there is also additional smd-1::gfp expression in ray neurons. | Paper_evidence | WBPaper00005693 | |||||
| WBPaper00024333 | |||||||||
| WBPaper00027214 | |||||||||
| WBPaper00028984 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 02 Dec 2010 00:00:00 | ||||||||
| Automated_description | Enables adenosylmethionine decarboxylase activity. Involved in spermidine biosynthetic process and spermine biosynthetic process. Predicted to be located in cytosol. Expressed in intestine and neurons. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and prostate cancer. Is an ortholog of human AMD1 (adenosylmethionine decarboxylase 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:457) | ||||
| DOID:10283 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:457) | ||||||
| Molecular_info | Corresponding_CDS | F47G4.7 | |||||||
| Corresponding_CDS_history | F47G4.7a:wp264 | ||||||||
| F47G4.7b:wp264 | |||||||||
| Corresponding_transcript | F47G4.7.1 | ||||||||
| F47G4.7.2 | |||||||||
| F47G4.7.3 | |||||||||
| Corresponding_transcript_history | F47G4.7b:wp263 | ||||||||
| Other_sequence (98) | |||||||||
| Associated_feature | WBsf649732 | ||||||||
| WBsf665088 | |||||||||
| WBsf716963 | |||||||||
| WBsf986018 | |||||||||
| WBsf019243 | |||||||||
| WBsf220565 | |||||||||
| Experimental_info | RNAi_result (18) | ||||||||
| Expr_pattern | Expr3120 | ||||||||
| Expr1012670 | |||||||||
| Expr1032416 | |||||||||
| Expr1151526 | |||||||||
| Expr2015903 | |||||||||
| Expr2034136 | |||||||||
| Drives_construct | WBCnstr00035347 | ||||||||
| Construct_product | WBCnstr00035347 | ||||||||
| Antibody | WBAntibody00002577 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (233) | |||||||||
| Interaction (38) | |||||||||
| Map_info | Map | I | Position | 22.9376 | Error | 0.009867 | |||
| Positive | Positive_clone | F47G4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00003357 | ||||||||
| WBPaper00005693 | |||||||||
| WBPaper00028984 | |||||||||
| WBPaper00035239 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00062707 | |||||||||
| WBPaper00064339 | |||||||||
| WBPaper00064947 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
