WormBase Tree Display for Gene: WBGene00004862
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| WBGene00004862 | Evidence | Paper_evidence | WBPaper00013343 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | T05A10 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | sma-9 | Person_evidence | WBPerson261 | |||||
| Sequence_name | T05A10.1 | ||||||||
| Molecular_name (38) | |||||||||
| Other_name | CELE_T05A10.1 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | sma-9 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sma | ||||||||
| Allele (216) | |||||||||
| Legacy_information | [Savage-Dunn C] Small and Mab (sensory ray and spicule abnormalities). | ||||||||
| Complementation_data | [Savage-Dunn C] complements sma-5(n678) | ||||||||
| Strain (18) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (41) | |||||||||
| Contained_in_operon | CEOPX001 | ||||||||
| Ortholog (43) | |||||||||
| Structured_description | Concise_description | sma-9 encodes, by extensive alternative splicing, at least 13 isoforms, a number of which are large (~2000-residue) proteins with at least three N-terminal involucrin domains, seven C-terminal zinc-finger domains, and a glutamine/asparagine-rich domain; SMA-9 is orthologous to the Drosophila Smad cofactor Schnurri (FBgn0003396) and the vertebrate HIVEP proteins (Human Immunodeficiency Virus Type 1 Enhancer-Binding Proteins, OMIM:194540, OMIM:143054, and OMIM:606649); in C. elegans, sma-9 functions in a subset of the TGF-beta-mediated signaling pathways that regulate body size and male tail patterning and morphogenesis; sma-9, through this pathway, also regulates reproductive aging; studies have shown that a reduction of TGF-beta pathway genes extends reproductive span by maintaining oocyte and germline quality; sma-9 also functions antagonistically to the TGF-beta signaling pathway, and in parallel to the lin-12/Notch pathway, to effect proper cell fate specification in the postembryonic mesodermal lineage, the M lineage; SMA-9 is widely expressed and localizes to nuclei. | Paper_evidence | WBPaper00005858 | |||||
| WBPaper00006346 | |||||||||
| WBPaper00027702 | |||||||||
| WBPaper00029226 | |||||||||
| WBPaper00035079 | |||||||||
| WBPaper00035556 | |||||||||
| WBPaper00037682 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson324 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 18 Jan 2011 00:00:00 | ||||||||
| Automated_description | Enables transcription coactivator activity and transcription corepressor activity. Involved in several processes, including determination of adult lifespan; nematode male tail tip morphogenesis; and regulation of gene expression. Acts upstream of or within cellular response to heat. Located in nucleus. Expressed in several structures, including excretory cell; intestine; spermatheca; ventral cord neurons; and vulva. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 43. Is an ortholog of human HIVEP1 (HIVEP zinc finger 1); HIVEP2 (HIVEP zinc finger 2); and HIVEP3 (HIVEP zinc finger 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:10652 | Homo sapiens | Paper_evidence | WBPaper00046027 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 21 Sep 2018 00:00:00 | ||||||||
| Potential_model | DOID:0070073 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4921) | |||||
| Models_disease_in_annotation | WBDOannot00000341 | ||||||||
| Molecular_info | Corresponding_CDS (11) | ||||||||
| Corresponding_CDS_history (13) | |||||||||
| Corresponding_transcript (16) | |||||||||
| Other_sequence (328) | |||||||||
| Associated_feature (25) | |||||||||
| Gene_product_binds (41) | |||||||||
| Transcription_factor | WBTranscriptionFactor000847 | ||||||||
| Experimental_info | RNAi_result (21) | ||||||||
| Expr_pattern | Expr2782 | ||||||||
| Expr2783 | |||||||||
| Expr3995 | |||||||||
| Expr10436 | |||||||||
| Expr1011744 | |||||||||
| Expr1032413 | |||||||||
| Expr1156052 | |||||||||
| Expr1200018 | |||||||||
| Expr2015897 | |||||||||
| Expr2034130 | |||||||||
| Drives_construct (15) | |||||||||
| Construct_product (11) | |||||||||
| Antibody | WBAntibody00000885 | ||||||||
| Microarray_results (83) | |||||||||
| Expression_cluster (163) | |||||||||
| Interaction (82) | |||||||||
| WBProcess | WBbiopr:00000025 | ||||||||
| WBbiopr:00000026 | |||||||||
| WBbiopr:00000033 | |||||||||
| Map_info | Map | X | Position | 2.51785 | Error | 0.028298 | |||
| Positive | Inside_rearr | nDf19 | |||||||
| yDp9 | |||||||||
| Positive_clone | T05A10 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| Negative | Outside_rearr | mnDp1 | |||||||
| mnDf1 | |||||||||
| yDp5 | |||||||||
| Mapping_data | 2_point | 7096 | |||||||
| 7097 | |||||||||
| 7099 | |||||||||
| Pos_neg_data | 10243 | ||||||||
| 10244 | |||||||||
| 10245 | |||||||||
| 10246 | |||||||||
| 10247 | |||||||||
| Reference (61) | |||||||||
| Picture | WBPicture0000013077 | ||||||||
| Method | Gene |
