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WormBase Tree Display for Gene: WBGene00004782

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Name Class

WBGene00004782SMapS_parentSequenceC26E6
IdentityVersion1
NameCGC_nameset-2Person_evidenceWBPerson632
Sequence_nameC26E6.9
Molecular_nameC26E6.9a
C26E6.9a.1
CE27735
C26E6.9b
CE01158
C26E6.9c
CE27736
C26E6.9b.1
C26E6.9c.1
Other_nameCELE_C26E6.9Accession_evidenceNDBBX284603
Public_nameset-2
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:36WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classset
Allele (92)
StrainWBStrain00027489
WBStrain00031733
WBStrain00032046
WBStrain00036215
WBStrain00000040
RNASeq_FPKM (74)
GO_annotation (21)
Contained_in_operonCEOP3240
Ortholog (40)
Paralog (19)
Structured_descriptionConcise_descriptionset-2 encodes a histone H3K4 methyltransferase closely related to the yeast Set1 and mammalian SET1/MLL proteins; SET-2 displays H3K4 methyltransferase activity in vitro and in C. elegans, regulates levels of H3K4; SET-2 plays a role in germline development, postembryonic development, negative regulation of lifespan in adult animals, and RNA interference; SET-2 localizes to nuclei.Paper_evidenceWBPaper00005020
WBPaper00032309
WBPaper00036383
Curator_confirmedWBPerson1843
Date_last_updated21 Sep 2010 00:00:00
Automated_descriptionEnables histone H3K4 methyltransferase activity. Involved in determination of adult lifespan and transdifferentiation. Located in nucleus. Expressed in several structures, including germ line; hermaphrodite distal tip cell; intestine; and nerve ring. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with speech impairment and dysmorphic facies. Is an ortholog of human SETD1A (SET domain containing 1A, histone lysine methyltransferase).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0070417Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:29010)
DOID:0070471Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:29010)
Molecular_infoCorresponding_CDSC26E6.9a
C26E6.9b
C26E6.9c
Corresponding_transcriptC26E6.9a.1
C26E6.9b.1
C26E6.9c.1
Other_sequence (35)
Associated_feature (11)
Experimental_infoRNAi_result (23)
Expr_pattern (14)
Drives_constructWBCnstr00005981
WBCnstr00013270
WBCnstr00013628
WBCnstr00019766
WBCnstr00020418
WBCnstr00035390
WBCnstr00042038
Construct_productWBCnstr00013270
WBCnstr00013628
WBCnstr00019766
WBCnstr00020473
WBCnstr00035390
Regulate_expr_cluster (12)
AntibodyWBAntibody00000438
Microarray_results (39)
Expression_clusterWBPaper00031040:TGF-beta_adult_downregulated
WBPaper00033065:cyc-1(RNAi)_downregulated
WBPaper00033065:isp-1-1(qm150)_downregulated
WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
WBPaper00037950:all-neurons_L1-larva_expressed
WBPaper00037950:all-neurons_L2-larva_expressed
WBPaper00037950:AVA-neuron_embryo_enriched
WBPaper00037950:AVA-neuron_L1-larva_expressed
WBPaper00037950:AVE-neuron_L1-larva_expressed
WBPaper00037950:BAG-neuron_blastula-embryo_expressed
WBPaper00037950:bodywall-muscle_L2-larva_expressed
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:coelomocytes_L1-larva_expressed
WBPaper00037950:coelomocytes_L2-larva_expressed
WBPaper00037950:coelomocytes_larva_enriched
WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
WBPaper00037950:hypodermis_L1-larva_expressed
WBPaper00044037:eat-2_downregulated
WBPaper00044656:tatn-1(qd182)_downregulated
WBPaper00044736:flat_dev_expression
WBPaper00044760:germline_specific
WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
WBPaper00045420:fertilization_downregulated_transcript
WBPaper00045521:Gender_Neutral
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
WBPaper00048988:neuron_expressed
WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
WBPaper00049920:Glucose-Diet_downregulated_N2
WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
WBPaper00049942:hsf-1(RNAi)_upregulated
WBPaper00050015:ifg-1(RNAi)_upregulated
WBPaper00050080:rbr-2(tm3141)_downregulated
WBPaper00050225:flp-6(RNAi)_upregulated
WBPaper00050234:lin-28(RNAi)_upregulated
WBPaper00050488:20C_vs_25C_regulated_N2_adult
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050522:mafr-1(tm6082)_downregulated
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050990:body-muscle_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00051039:germline_enriched
WBPaper00051265:F4_hrde-1(tm1200)_upregulated
WBPaper00051265:F4_morc-1(tm6048)_upregulated
WBPaper00052884:emb-4(hc60)_downregulated
WBPaper00053184:sma-2(rax5)_downregulated
WBPaper00053184:sma-4(rax3)_downregulated
WBPaper00053289:DREAM-target
WBPaper00053302:stavudine_24h_regulated
WBPaper00053713:Starvation-induced_postdauer_vs_control_downregulated
WBPaper00055226:ADR-2_target_N2
WBPaper00055334:DLC-1_interacting
WBPaper00055354:eat-2(ad1116)_downregulated
WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated
WBPaper00055648:germline_expressed
WBPaper00055971:nhl-2(ok818)_20C_upregulated
WBPaper00055971:nhl-2(ok818)_25C_upregulated
WBPaper00056034:pals-22(jy3)_downregulated
WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
WBPaper00056868:P.aeruginosa_upregulated_smallRNA
WBPaper00057288:Cold_downregulated_transcript
WBPaper00057288:iff-1(RNAi)_downregulated_transcript
WBPaper00058691:CFP-1_interacting_protein
WBPaper00058691:set-2(bn129)_downregulated
WBPaper00058691:WDR-5.1_interacting_protein
WBPaper00058725:sftb-1(cer6)_upregulated
WBPaper00059174:MEG-3_interacting
WBPaper00059356:BAZ-2_SET-6_interacting
WBPaper00059664:srbc-48(ac23)_downregulated
WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
WBPaper00060014:set-2(tm1630)_upregulated
WBPaper00060100:SiNP_upregulated_mRNA
WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
WBPaper00060445:ikb-1(nr2027)_upregulated_L4
WBPaper00060445:nfki-1(cer1)_upregulated_L4
WBPaper00060683:hlh-11(ko1)_downregulated
WBPaper00060811:L1_vs_adult_upregulated_neural
WBPaper00061203:spr-1(ok2144)_downregulated
WBPaper00061274:microgravity_upregulated
WBPaper00061340:ADA_ADE_grandparent
WBPaper00061340:I2_grandparent
WBPaper00061340:Neuroblast_ADE_ADA
WBPaper00061340:Neuroblast_AIZ_FLP
WBPaper00061340:Neuroblast_ASH_RIB
WBPaper00061478:SUMO-conjugated_protein
WBPaper00061527:cids-2_2203-attf-2_2451
WBPaper00061527:dpy-26-B0205.1
WBPaper00062159:hda-2(ok1479)_downregulated
WBPaper00062193:hsf-1(RNAi)_downregulated
WBPaper00062193:skn-1(RNAi)_downregulated
WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064494:postdauer_upregulated_AWA
WBPaper00064716:paraquat_upregulated
WBPaper00064871:hypoxia_upregulated_F1
WBPaper00065086:N2_N.ausubeli_regulated
WBPaper00065841:1_0
WBPaper00065993:glp-1(e2141)_downregulated
cgc4386_cluster_5_1
cgc4489_group_25
WBPaper00025032:cluster_7
WBPaper00025032:cluster_68
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00031003:24hr_muscle_depleted
WBPaper00031003:total_muscle_depleted
WBPaper00031252:AIN-1_IP_enriched
WBPaper00035084:L1_enriched_AIN-2_IP
WBPaper00035084:L4_enriched_AIN-2_IP
WBPaper00035905:FBF-1_Associated
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
WBPaper00040823:alg-1(gk214)_downregulated
WBPaper00040858:eQTL_age_regulated_aging
WBPaper00040858:eQTL_regulated_old
WBPaper00041002:HF_3d_2.0mM_Down
WBPaper00041002:HF_11d_2.0mM_Up
WBPaper00041002:HQ_3d_2.0mM_Down
WBPaper00041606:CE_B.thuringiensis-DB27_regulated
WBPaper00041606:CE_S.marcescens_regulated
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00041960:N2_fasting_upregulated_anytime
WBPaper00042331:a-SWCNTs_downregulated
WBPaper00045263:0.1mM-paraquat_upregulated
WBPaper00045263:nuo-6(qm200)_upregulated
WBPaper00045960:L1-L4-lethargus_downregulated
WBPaper00045960:L4-lethargus_downregulated
WBPaper00053236:Starvation_regulated_GR1307
WBPaper00053236:Starvation_regulated_N2
[cgc5767]:cluster_26
[cgc5767]:expression_class_E
[cgc5767]:expression_class_ET
[cgc5767]:expression_class_ET_max(143_min)
[cgc5767]:expression_class_E_pi(53_min)
[cgc5767]:expression_class_M
[cgc5767]:expression_class_ME
[cgc5767]:expression_class_MET
[cgc6390]:intrinsic
Interaction (45)
Map_infoMapIIIPosition-2.35202Error0.002862
PositivePositive_cloneC26E6Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Pseudo_map_position
Reference (65)
RemarkSequence connection from [Strome S], 02/06/13 krb.
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene