set-2 encodes a histone H3K4 methyltransferase closely related to the yeast Set1 and mammalian SET1/MLL proteins; SET-2 displays H3K4 methyltransferase activity in vitro and in C. elegans, regulates levels of H3K4; SET-2 plays a role in germline development, postembryonic development, negative regulation of lifespan in adult animals, and RNA interference; SET-2 localizes to nuclei.
Enables histone H3K4 methyltransferase activity. Involved in determination of adult lifespan and transdifferentiation. Located in nucleus. Expressed in several structures, including germ line; hermaphrodite distal tip cell; intestine; and nerve ring. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with speech impairment and dysmorphic facies. Is an ortholog of human SETD1A (SET domain containing 1A, histone lysine methyltransferase).
Sequence connection from [Strome S], 02/06/13 krb.
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.