WormBase Tree Display for Gene: WBGene00004779
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| WBGene00004779 | Evidence | Paper_evidence | WBPaper00002710 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | Y22D7AR | ||||||
| Identity | Version | 3 | |||||||
| Name | CGC_name | ser-4 | Person_evidence | WBPerson32 | |||||
| Sequence_name | Y22D7AR.13 | ||||||||
| Molecular_name | Y22D7AR.13 | ||||||||
| Y22D7AR.13.1 | |||||||||
| CE29370 | |||||||||
| Other_name | cer-1 | Paper_evidence | WBPaper00002710 | ||||||
| WBPaper00006180 | |||||||||
| 5HT-Ce | Paper_evidence | WBPaper00002710 | |||||||
| WBPaper00006180 | |||||||||
| CELE_Y22D7AR.13 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | ser-4 | ||||||||
| DB_info | Database | AceView | gene | 3C814 | |||||
| WormQTL | gene | WBGene00004779 | |||||||
| WormFlux | gene | WBGene00004779 | |||||||
| NDB | locus_tag | CELE_Y22D7AR.13 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00004779|UniProtKB=G5EGH0 | |||||||
| family | PTHR24247 | ||||||||
| NCBI | gene | 175322 | |||||||
| RefSeq | protein | NM_065051.8 | |||||||
| TrEMBL | UniProtAcc | G5EGH0 | |||||||
| UniProt_GCRP | UniProtAcc | G5EGH0 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 15 Dec 2005 15:56:16 | WBPerson2970 | Name_change | Other_name | cer-1 | ||||
| 3 | 15 Dec 2005 15:56:16 | WBPerson2970 | Name_change | Other_name | 5HT-Ce | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ser | ||||||||
| Allele (265) | |||||||||
| Strain | WBStrain00031461 | ||||||||
| WBStrain00000209 | |||||||||
| WBStrain00055583 | |||||||||
| WBStrain00055584 | |||||||||
| WBStrain00055062 | |||||||||
| WBStrain00055576 | |||||||||
| WBStrain00055575 | |||||||||
| WBStrain00055580 | |||||||||
| WBStrain00055579 | |||||||||
| WBStrain00055574 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (27) | |||||||||
| Ortholog (44) | |||||||||
| Paralog (20) | |||||||||
| Structured_description | Concise_description | ser-4 encodes an ortholog of mammalian 5-HT1 metabotropic serotoninreceptors; SER-4 is required for normal inhibition of movement by 5-HT,with ser-4 mutants being hyperactive; SER-4 is partly required for maletail curling, with ser-4 mutants showing reduced curling in exogenous5-HT; SER-4 is dispensable for the stimulation of egg-laying by 5-HT andby the uptake inhibitor fluoxetine; SER-4 may actually inhibitegg-laying, since egg-laying ser-4 mutants are moderately hypersensitiveto 5-HT, and mutant ser-4 hermaphrodites are partly depleted of eggs,suggesting that their egg-laying is weakly constitutive; however, SER-4is required for stimulation of egg-laying by the tricyclicantidepressant imipramine, suggesting that imipramine drives HSNs tosecrete some non-5-HT neurotransmitter which then activates SER-4; SER-4is expressed in neurons (RIB and RIS, other head, pharyngeal,sublateral, retrovesicular ganglion, PVT, and either DVA or DVC); SER-4has a low affinity for serotonin (5-HT), and overall pharmacologicalsimilarities to mammalian 5-HT1 receptors; SER-4 is probably antagonizedby mianserin; heterologously expressed SER-4, when challenged with 5-HT,diminishes intracellular adenylate cyclase activity; LIM-6 is requiredfor normal expression of SER-4 in RIS interneurons. | Paper_evidence | WBPaper00002710 | |||||
| WBPaper00006180 | |||||||||
| WBPaper00024420 | |||||||||
| WBPaper00024527 | |||||||||
| WBPaper00025141 | |||||||||
| WBPaper00025145 | |||||||||
| WBPaper00026843 | |||||||||
| WBPaper00028762 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 20 Dec 2006 00:00:00 | ||||||||
| Automated_description | Enables G protein-coupled serotonin receptor activity. Involved in regulation of locomotion and serotonin receptor signaling pathway. Predicted to be located in dendrite. Expressed in neurons; vm2; and vulval cell. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; attention deficit hyperactivity disorder; conduct disorder; and panic disorder. Is an ortholog of human HTR1A (5-hydroxytryptamine receptor 1A). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:12995 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5287) | ||||
| DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5286) | ||||||
| DOID:594 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5286) | ||||||
| DOID:0060001 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5286) | ||||||
| DOID:2030 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5286) | ||||||
| DOID:1596 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5286) | ||||||
| DOID:1094 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5287) | ||||||
| DOID:0050741 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5286) | ||||||
| Molecular_info | Corresponding_CDS | Y22D7AR.13 | |||||||
| Corresponding_transcript | Y22D7AR.13.1 | ||||||||
| Other_sequence (32) | |||||||||
| Associated_feature (14) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00069695 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00069703 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00069737 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00027718 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00055679 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00069727 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00069719 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00069711 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr2710 | ||||||||
| Expr4333 | |||||||||
| Expr10554 | |||||||||
| Expr13790 | |||||||||
| Expr13883 | |||||||||
| Expr16105 | |||||||||
| Expr1013909 | |||||||||
| Expr1159204 | |||||||||
| Expr2015749 | |||||||||
| Expr2033982 | |||||||||
| Drives_construct | WBCnstr00000004 | ||||||||
| WBCnstr00006800 | |||||||||
| WBCnstr00011926 | |||||||||
| WBCnstr00015416 | |||||||||
| WBCnstr00042764 | |||||||||
| Construct_product | WBCnstr00040229 | ||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (171) | |||||||||
| Interaction | WBInteraction000133998 | ||||||||
| WBInteraction000136821 | |||||||||
| WBInteraction000136913 | |||||||||
| WBInteraction000138057 | |||||||||
| WBInteraction000139088 | |||||||||
| WBInteraction000140940 | |||||||||
| WBInteraction000172909 | |||||||||
| WBInteraction000175561 | |||||||||
| WBInteraction000361546 | |||||||||
| WBProcess | WBbiopr:00000001 | ||||||||
| Map_info | Map | III | Position | -18.935 | Error | 0.267694 | |||
| Positive | Positive_clone | Y22D7AR | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4656 | |||||||
| Pseudo_map_position | |||||||||
| Reference (75) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
