WormBase Tree Display for Gene: WBGene00004779
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WBGene00004779 | Evidence | Paper_evidence | WBPaper00002710 | ||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | Y22D7AR | ||||
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | ser | ||||||
Allele (265) | |||||||
Strain | WBStrain00031461 | ||||||
WBStrain00000209 | |||||||
WBStrain00055583 | |||||||
WBStrain00055584 | |||||||
WBStrain00055062 | |||||||
WBStrain00055576 | |||||||
WBStrain00055575 | |||||||
WBStrain00055580 | |||||||
WBStrain00055579 | |||||||
WBStrain00055574 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (27) | |||||||
Ortholog (44) | |||||||
Paralog (20) | |||||||
Structured_description | Concise_description | ser-4 encodes an ortholog of mammalian 5-HT1 metabotropic serotoninreceptors; SER-4 is required for normal inhibition of movement by 5-HT,with ser-4 mutants being hyperactive; SER-4 is partly required for maletail curling, with ser-4 mutants showing reduced curling in exogenous5-HT; SER-4 is dispensable for the stimulation of egg-laying by 5-HT andby the uptake inhibitor fluoxetine; SER-4 may actually inhibitegg-laying, since egg-laying ser-4 mutants are moderately hypersensitiveto 5-HT, and mutant ser-4 hermaphrodites are partly depleted of eggs,suggesting that their egg-laying is weakly constitutive; however, SER-4is required for stimulation of egg-laying by the tricyclicantidepressant imipramine, suggesting that imipramine drives HSNs tosecrete some non-5-HT neurotransmitter which then activates SER-4; SER-4is expressed in neurons (RIB and RIS, other head, pharyngeal,sublateral, retrovesicular ganglion, PVT, and either DVA or DVC); SER-4has a low affinity for serotonin (5-HT), and overall pharmacologicalsimilarities to mammalian 5-HT1 receptors; SER-4 is probably antagonizedby mianserin; heterologously expressed SER-4, when challenged with 5-HT,diminishes intracellular adenylate cyclase activity; LIM-6 is requiredfor normal expression of SER-4 in RIS interneurons. | Paper_evidence | WBPaper00002710 | |||
WBPaper00006180 | |||||||
WBPaper00024420 | |||||||
WBPaper00024527 | |||||||
WBPaper00025141 | |||||||
WBPaper00025145 | |||||||
WBPaper00026843 | |||||||
WBPaper00028762 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 20 Dec 2006 00:00:00 | ||||||
Automated_description | Enables G protein-coupled serotonin receptor activity. Involved in regulation of locomotion and serotonin receptor signaling pathway. Predicted to be located in dendrite. Expressed in neurons; vm2; and vulval cell. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; attention deficit hyperactivity disorder; conduct disorder; and panic disorder. Is an ortholog of human HTR1A (5-hydroxytryptamine receptor 1A). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:12995 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5287) | ||
DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5286) | ||||
DOID:594 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5286) | ||||
DOID:0060001 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5286) | ||||
DOID:2030 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5286) | ||||
DOID:1596 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5286) | ||||
DOID:1094 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5287) | ||||
DOID:0050741 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5286) | ||||
Molecular_info | Corresponding_CDS | Y22D7AR.13 | |||||
Corresponding_transcript | Y22D7AR.13.1 | ||||||
Other_sequence (32) | |||||||
Associated_feature (14) | |||||||
Experimental_info | RNAi_result | WBRNAi00069695 | Inferred_automatically | RNAi_primary | |||
WBRNAi00069703 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00069737 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00027718 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00055679 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00069727 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00069719 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00069711 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr2710 | ||||||
Expr4333 | |||||||
Expr10554 | |||||||
Expr13790 | |||||||
Expr13883 | |||||||
Expr16105 | |||||||
Expr1013909 | |||||||
Expr1159204 | |||||||
Expr2015749 | |||||||
Expr2033982 | |||||||
Drives_construct | WBCnstr00000004 | ||||||
WBCnstr00006800 | |||||||
WBCnstr00011926 | |||||||
WBCnstr00015416 | |||||||
WBCnstr00042764 | |||||||
Construct_product | WBCnstr00040229 | ||||||
Microarray_results (18) | |||||||
Expression_cluster (171) | |||||||
Interaction | WBInteraction000133998 | ||||||
WBInteraction000136821 | |||||||
WBInteraction000136913 | |||||||
WBInteraction000138057 | |||||||
WBInteraction000139088 | |||||||
WBInteraction000140940 | |||||||
WBInteraction000172909 | |||||||
WBInteraction000175561 | |||||||
WBInteraction000361546 | |||||||
WBProcess | WBbiopr:00000001 | ||||||
Map_info | Map | III | Position | -18.935 | Error | 0.267694 | |
Positive | Positive_clone | Y22D7AR | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Mapping_data | Multi_point | 4656 | |||||
Pseudo_map_position | |||||||
Reference (75) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |