WormBase Tree Display for Gene: WBGene00004764
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| WBGene00004764 | Evidence | Person_evidence | WBPerson220 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | CHROMOSOME_X | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | sel-7 | Person_evidence | WBPerson220 | |||||
| Sequence_name | K04G11.2 | ||||||||
| Molecular_name | K04G11.2 | ||||||||
| K04G11.2.1 | |||||||||
| CE35893 | |||||||||
| Other_name | CELE_K04G11.2 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | sel-7 | ||||||||
| DB_info | Database | AceView | gene | XO950 | |||||
| WormQTL | gene | WBGene00004764 | |||||||
| SignaLink | protein | WBGene00004764 | |||||||
| WormFlux | gene | WBGene00004764 | |||||||
| NDB | locus_tag | CELE_K04G11.2 | |||||||
| NCBI | gene | 181539 | |||||||
| RefSeq | protein | NM_077991.7 | |||||||
| SwissProt | UniProtAcc | G5EGS7 | |||||||
| UniProt_GCRP | UniProtAcc | G5EGS7 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sel | ||||||||
| Allele (173) | |||||||||
| Legacy_information | See also n1253 | ||||||||
| [C.elegansII] n1253 : suppressor of lin-12 hypermorph (n302sd)[JT; MT] | |||||||||
| Complementation_data | [Thomas J] complements sup-20(n821), let-4(mn105) | ||||||||
| Strain | WBStrain00022824 | ||||||||
| WBStrain00008056 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (13) | |||||||||
| Ortholog (30) | |||||||||
| Structured_description | Concise_description | sel-7 encodes a novel protein with two predicted PEST sequences that is conserved in the related nematode C. briggsae and several parasitic nematodes, but has no known homologs in other organisms; sel-7 was identified in screens for suppressors of dominant lin-12 mutations that result in vulvaless and egg-laying defective animals; although loss of SEL-7 function via mutation or RNAi results in no obvious defects in a wild-type background, genetic studies suggests that SEL-7 acts downstream of LIN-12/Notch to positively regulate LIN-12 signaling, perhaps by regulating the activity or formation of the LAG-1, LIN-12(intra), SEL-8 nuclear complex; in vitro, SEL-7 self-associates and also interacts with TIR-1 (F13B10.1B), a protein that contains sterile alpha and Toll interleukin receptor motifs, and MDT-29 (K08E3.8), a glutamine-rich protein similar to mediator complex subunits, however the functional significance of these interactions is not yet known; a SEL-7::GFP translational fusion reveals expression in the nuclei of several cell types, including vulval precursor cells and those of the developing gonad. | Paper_evidence | WBPaper00002959 | |||||
| WBPaper00006438 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 10 Aug 2004 00:00:00 | ||||||||
| Automated_description | Enables identical protein binding activity and sequence-specific DNA binding activity. Involved in several processes, including lateral inhibition; negative regulation of transcription by RNA polymerase II; and positive regulation of Notch signaling pathway. Located in nucleus. Expressed in body wall musculature; pharyngeal muscle cell; and seam cell. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | K04G11.2 | |||||||
| Corresponding_CDS_history | K04G11.2:wp111 | ||||||||
| Corresponding_transcript | K04G11.2.1 | ||||||||
| Other_sequence (27) | |||||||||
| Associated_feature (16) | |||||||||
| Experimental_info | RNAi_result (13) | ||||||||
| Expr_pattern | Expr2853 | ||||||||
| Expr2854 | |||||||||
| Expr8992 | |||||||||
| Expr1011523 | |||||||||
| Expr1032358 | |||||||||
| Expr1153632 | |||||||||
| Expr2015735 | |||||||||
| Expr2033968 | |||||||||
| Drives_construct | WBCnstr00010988 | ||||||||
| WBCnstr00013660 | |||||||||
| WBCnstr00035402 | |||||||||
| Construct_product | WBCnstr00000028 | ||||||||
| WBCnstr00010988 | |||||||||
| WBCnstr00013660 | |||||||||
| WBCnstr00035402 | |||||||||
| Microarray_results (24) | |||||||||
| Expression_cluster (132) | |||||||||
| Interaction (28) | |||||||||
| Map_info | Map | X | Position | 16.6845 | Error | 0.003109 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | K04G11 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | 2_point | 6123 | |||||||
| 6124 | |||||||||
| Multi_point | 2292 | ||||||||
| 4606 | |||||||||
| Pos_neg_data | 6840 | ||||||||
| 6841 | |||||||||
| 6842 | |||||||||
| 6843 | |||||||||
| 6844 | |||||||||
| 6845 | |||||||||
| 6846 | |||||||||
| Reference (12) | |||||||||
| Method | Gene |
