WormBase Tree Display for Gene: WBGene00004764
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WBGene00004764 | Evidence | Person_evidence | WBPerson220 | ||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | CHROMOSOME_X | ||||
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | sel | ||||||
Allele (173) | |||||||
Legacy_information | See also n1253 | ||||||
[C.elegansII] n1253 : suppressor of lin-12 hypermorph (n302sd)[JT; MT] | |||||||
Complementation_data | [Thomas J] complements sup-20(n821), let-4(mn105) | ||||||
Strain | WBStrain00022824 | ||||||
WBStrain00008056 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (13) | |||||||
Ortholog (30) | |||||||
Structured_description | Concise_description | sel-7 encodes a novel protein with two predicted PEST sequences that is conserved in the related nematode C. briggsae and several parasitic nematodes, but has no known homologs in other organisms; sel-7 was identified in screens for suppressors of dominant lin-12 mutations that result in vulvaless and egg-laying defective animals; although loss of SEL-7 function via mutation or RNAi results in no obvious defects in a wild-type background, genetic studies suggests that SEL-7 acts downstream of LIN-12/Notch to positively regulate LIN-12 signaling, perhaps by regulating the activity or formation of the LAG-1, LIN-12(intra), SEL-8 nuclear complex; in vitro, SEL-7 self-associates and also interacts with TIR-1 (F13B10.1B), a protein that contains sterile alpha and Toll interleukin receptor motifs, and MDT-29 (K08E3.8), a glutamine-rich protein similar to mediator complex subunits, however the functional significance of these interactions is not yet known; a SEL-7::GFP translational fusion reveals expression in the nuclei of several cell types, including vulval precursor cells and those of the developing gonad. | Paper_evidence | WBPaper00002959 | |||
WBPaper00006438 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 10 Aug 2004 00:00:00 | ||||||
Automated_description | Enables identical protein binding activity and sequence-specific DNA binding activity. Involved in several processes, including lateral inhibition; negative regulation of transcription by RNA polymerase II; and positive regulation of Notch signaling pathway. Located in nucleus. Expressed in body wall musculature; pharyngeal muscle cell; and seam cell. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | K04G11.2 | |||||
Corresponding_CDS_history | K04G11.2:wp111 | ||||||
Corresponding_transcript | K04G11.2.1 | ||||||
Other_sequence (27) | |||||||
Associated_feature (16) | |||||||
Experimental_info | RNAi_result (13) | ||||||
Expr_pattern | Expr2853 | ||||||
Expr2854 | |||||||
Expr8992 | |||||||
Expr1011523 | |||||||
Expr1032358 | |||||||
Expr1153632 | |||||||
Expr2015735 | |||||||
Expr2033968 | |||||||
Drives_construct | WBCnstr00010988 | ||||||
WBCnstr00013660 | |||||||
WBCnstr00035402 | |||||||
Construct_product | WBCnstr00000028 | ||||||
WBCnstr00010988 | |||||||
WBCnstr00013660 | |||||||
WBCnstr00035402 | |||||||
Microarray_results (24) | |||||||
Expression_cluster (132) | |||||||
Interaction (28) | |||||||
Map_info | Map | X | Position | 16.6845 | Error | 0.003109 | |
Well_ordered | |||||||
Positive | Positive_clone | K04G11 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | 2_point | 6123 | |||||
6124 | |||||||
Multi_point | 2292 | ||||||
4606 | |||||||
Pos_neg_data | 6840 | ||||||
6841 | |||||||
6842 | |||||||
6843 | |||||||
6844 | |||||||
6845 | |||||||
6846 | |||||||
Reference (12) | |||||||
Method | Gene |