san-1 encodes the C. elegans ortholog of the Saccharomyces cerevisiae spindle checkpoint protein Mad3p; san-1 is essential for the mitotic spindle checkpoint activity in response to stimuli such as microtubule depolymerization or anoxia, in which microscopically visible movement ceases and cell cycle progression reversibly arrests; san-1 has also been reported to be essential for normal embryonic development; SAN-1 localizes to the nucleus during prophase and, during metaphase, colocalizes with HCP-3 to the kinetochore, consistent with a role as a spindle checkpoint component.
Predicted to enable protein kinase activity. Involved in mitotic spindle assembly checkpoint signaling and response to anoxia. Located in kinetochore and nucleoplasm.
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.
CGC_data_submission
This gene has been named mad (Mitotic Arrest Deficient) in other species and so mad-3 has been added as an other_name