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WormBase Tree Display for Gene: WBGene00004393

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Name Class

WBGene00004393SMapS_parentSequenceB0414
IdentityVersion1
NameCGC_namernt-1Person_evidenceWBPerson83
Sequence_nameB0414.2
Molecular_nameB0414.2
B0414.2.1
CE24772
B0414.2.2
B0414.2.3
Other_namerunAccession_evidenceAF153275
mab-2Person_evidenceWBPerson759
WBPerson699
WBPerson3750
run-1Paper_evidenceWBPaper00003892
CELE_B0414.2Accession_evidenceNDBBX284601
Public_namernt-1
DB_infoDatabase (12)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:35WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classrnt
Reference_alleleWBVar00143855
Allele (143)
Legacy_informatione1241 : adult male has 6-18 missing copulatory rays as a result of variable failures of V and T lineages bursa often grossly distorted. ME0/ME1. Hermaphrodite gross phenotype normal late hypodermal V and T divisions variably defective. ES1 (hermaphrodite) ES3 (adult male). NA1.
See also e1241
[C.elegansII] e1241 : adult male has 6-18 missing copulatory rays as a result of variable failures of V and T lineages; bursa often grossly distorted. ME0/ME1. Hermaphrodite gross phenotype normal; late hypodermal V and T divisions variably defective. ES1 (hermaphrodite) ES3 (adult male). NA1. [Hodgkin 1983a; Link et al. 1988; CB]
StrainWBStrain00035360
WBStrain00035361
WBStrain00035362
WBStrain00040727
WBStrain00001748
WBStrain00035579
WBStrain00004456
WBStrain00008477
WBStrain00051045
RNASeq_FPKM (74)
GO_annotation (36)
OrthologWBGene00066598Caenorhabditis remaneiFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00026814Caenorhabditis briggsaeFrom_analysisHillier-set
OrthoMCL
OMA
Inparanoid_8
WormBase-Compara
WBGene00155187Caenorhabditis brenneriFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00159354Caenorhabditis brenneriFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00177505Caenorhabditis japonicaFrom_analysisInparanoid_8
WBGene00222060Brugia malayiFrom_analysisWormBase-Compara
CBOVI.g10293Caenorhabditis bovisFrom_analysisWormBase-Compara
CSP21.g3704Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP26.g2005Caenorhabditis zanzibariFrom_analysisWormBase-Compara
CSP28.g3802Caenorhabditis panamensisFrom_analysisWormBase-Compara
CSP29.g11185Caenorhabditis beceiFrom_analysisWormBase-Compara
CSP31.g6294Caenorhabditis uteleiaFrom_analysisWormBase-Compara
CSP32.g15536Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP38.g434Caenorhabditis quiockensisFrom_analysisWormBase-Compara
CSP39.g15399Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP40.g19852Caenorhabditis tribulationisFrom_analysisWormBase-Compara
Cni-rnt-1Caenorhabditis nigoniFrom_analysisWormBase-Compara
Csp11.Scaffold630.g17043Caenorhabditis tropicalisFrom_analysisWormBase-Compara
FL83_14294Caenorhabditis latensFrom_analysisWormBase-Compara
GCK72_001002Caenorhabditis remaneiFrom_analysisWormBase-Compara
OTIPU.nOt.2.0.1.g05979Oscheius tipulaeFrom_analysisWormBase-Compara
Pan_g20903Panagrellus redivivusFrom_analysisWormBase-Compara
Sp34_10296500Caenorhabditis inopinataFrom_analysisWormBase-Compara
chrI_pilon.g993Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00238576Onchocerca volvulusFrom_analysisWormBase-Compara
WBGene00107225Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00273211Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00258756Strongyloides rattiFrom_analysisWormBase-Compara
WBGene00289565Trichuris murisFrom_analysisWormBase-Compara
FB:FBgn0002576Drosophila melanogasterFrom_analysisOrthoFinder
OrthoInspector
Panther
FB:FBgn0259162Drosophila melanogasterFrom_analysisOrthoFinder
OrthoInspector
Panther
FB:FBgn0003300Drosophila melanogasterFrom_analysisEnsEMBL-Compara
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
FB:FBgn0083981Drosophila melanogasterFrom_analysisOrthoFinder
OrthoInspector
Panther
SonicParanoid
ZFIN:ZDB-GENE-000605-1Danio rerioFrom_analysisInparanoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
ZFIN:ZDB-GENE-000605-2Danio rerioFrom_analysisEnsEMBL-Compara
Inparanoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
ZFIN:ZDB-GENE-040629-3Danio rerioFrom_analysisEnsEMBL-Compara
Inparanoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
ZFIN:ZDB-GENE-040629-4Danio rerioFrom_analysisEnsEMBL-Compara
Inparanoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
HGNC:10472Homo sapiensFrom_analysisEnsEMBL-Compara
Inparanoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
HGNC:10471Homo sapiensFrom_analysisInparanoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
HGNC:10473Homo sapiensFrom_analysisEnsEMBL-Compara
Inparanoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
MGI:99829Mus musculusFrom_analysisEnsEMBL-Compara
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
MGI:99852Mus musculusFrom_analysisOrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
MGI:102672Mus musculusFrom_analysisEnsEMBL-Compara
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
RGD:2283Rattus norvegicusFrom_analysisOrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
RGD:620082Rattus norvegicusFrom_analysisEnsEMBL-Compara
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
RGD:2282Rattus norvegicusFrom_analysisEnsEMBL-Compara
OrthoFinder
OrthoInspector
PhylomeDB
Structured_descriptionConcise_descriptionrnt-1 encodes a transcription factor that is the sole C. elegans member of the Runx family of transcriptional regulators; rnt-1 activity is required for several developmental processes, including regulation of hypodermal seam cell proliferation and proper development of the male tail; rnt-1 mutant animals also exhibit a slight reduction in body size which is enhanced by starvation; RNT-1 can physically interact with SMA-4 and regulates, either directly or indirectly, expression of tlp-1 and cki-1, which encode a C2H2 zinc finger and CDK inhibitor, respectively; RNT-1::GFP reporter fusions are expressed in the nuclei of hypodermal seam cells and transiently in body wall muscles; in males, a RNT-1::GFP is expressed in cells derived from the V5, V6 and T lineages that give rise to the sensory rays.Paper_evidenceWBPaper00005040
WBPaper00024401
WBPaper00026860
WBPaper00026868
Curator_confirmedWBPerson1843
WBPerson1823
WBPerson567
Date_last_updated03 Jan 2011 00:00:00
Automated_descriptionEnables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and SMAD binding activity. Involved in several processes, including nematode male tail tip morphogenesis; positive regulation of locomotion involved in locomotory behavior; and regulation of gene expression. Acts upstream of or within dopamine metabolic process. Located in nucleus. Part of core-binding activity factor complex. Expressed in body wall musculature; intestine; neurons; ray precursor cell; and seam cell. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); invasive ductal carcinoma; and osteochondrodysplasia (multiple). Is an ortholog of human RUNX2 (RUNX family transcription factor 2) and RUNX3 (RUNX family transcription factor 3).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_model (23)
Molecular_infoCorresponding_CDSB0414.2
Corresponding_transcriptB0414.2.1
B0414.2.2
B0414.2.3
Other_sequenceCBC12954_1
Associated_feature (23)
Transcription_factorWBTranscriptionFactor000199
Experimental_infoRNAi_resultWBRNAi00065557Inferred_automaticallyRNAi_primary
WBRNAi00039038Inferred_automaticallyRNAi_primary
WBRNAi00028240Inferred_automaticallyRNAi_primary
WBRNAi00063834Inferred_automaticallyRNAi_primary
WBRNAi00064608Inferred_automaticallyRNAi_primary
WBRNAi00063835Inferred_automaticallyRNAi_primary
WBRNAi00002853Inferred_automaticallyRNAi_primary
WBRNAi00001354Inferred_automaticallyRNAi_primary
Expr_pattern (22)
Drives_construct (13)
Construct_productWBCnstr00010470
WBCnstr00011148
WBCnstr00012390
WBCnstr00012969
WBCnstr00016840
WBCnstr00018817
WBCnstr00018818
WBCnstr00022571
WBCnstr00035514
Microarray_results (20)
Expression_cluster (119)
Interaction (127)
WBProcessWBbiopr:00000025
WBbiopr:00000073
WBbiopr:00000112
Map_infoMapIPosition0.447019Error0.000263
PositivePositive_cloneB0414Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_data2_point329
Multi_point205
4641
5090
Reference (75)
Remark
MethodGene