WormBase Tree Display for Gene: WBGene00004368

WBGene00004368 SMap: S_parent: Sequence: C32E8
  Identity: Version: 1
    Name: CGC_name: ric-19 Person_evidence: WBPerson508
      Sequence_name: C32E8.7
      Molecular_name: C32E8.7
        C32E8.7.1
        CE39089
      Other_name: CELE_C32E8.7 Accession_evidence: NDB BX284601
      Public_name: ric-19
    DB_info: Database: AceView gene 1E346
        WormQTL gene WBGene00004368
        WormFlux gene WBGene00004368
        NDB locus_tag CELE_C32E8.7
        Panther gene CAEEL|WormBase=WBGene00004368|UniProtKB=P91124
          family PTHR10164
        NCBI gene 191757
        RefSeq protein NM_058815.5
        SwissProt UniProtAcc P91124
        TREEFAM TREEFAM_ID TF317186
        UniProt_GCRP UniProtAcc P91124
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:35 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ric
    Allele (58)
    Strain: WBStrain00031152
      WBStrain00031153
      WBStrain00031155
      WBStrain00031156
      WBStrain00031157
      WBStrain00031158
      WBStrain00028987
      WBStrain00031657
    RNASeq_FPKM (74)
    GO_annotation (22)
    Ortholog (37)
    Structured_description: Automated_description: Enables small GTPase binding activity. Involved in dense core granule maturation; regulation of locomotion involved in locomotory behavior; and regulation of neurotransmitter secretion. Located in Golgi apparatus. Expressed in several structures, including excretory system; head; intestine; muscle cell; and nervous system. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Is an ortholog of human ICA1L (islet cell autoantigen 1 like). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:9744 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:5343)
  Molecular_info: Corresponding_CDS: C32E8.7
    Corresponding_CDS_history: C32E8.7:wp148
    Corresponding_transcript: C32E8.7.1
    Other_sequence (34)
    Associated_feature: WBsf649049
      WBsf649050
      WBsf664071
      WBsf983239
      WBsf1009559
      WBsf219176
  Experimental_info: RNAi_result: WBRNAi00041693 Inferred_automatically: RNAi_primary
      WBRNAi00003061 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1071
      Expr1072
      Expr11536
      Expr15247
      Expr1012966
      Expr1032181
      Expr1145714
      Expr2015345
      Expr2033579
    Drives_construct (14)
    Construct_product: WBCnstr00000454
      WBCnstr00000455
      WBCnstr00010065
      WBCnstr00021869
      WBCnstr00035534
    Antibody: WBAntibody00000320
    Microarray_results (18)
    Expression_cluster: WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:A-class-motor-neurons_larva_enriched
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_larva_enriched
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:BAG-neuron_embryo_enriched
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:dopaminergic-neurons_larva_enriched
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_larva_enriched
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_larva_enriched
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00044736:flat_dev_expression
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_upregulated
      WBPaper00046509:lin-35(n745)_upregulated
      WBPaper00048988:neuron_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049495:starvation-refeeding_regulated
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_100-cell-embryo
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050496:unc-39(hp701)_regulated
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:intestine_enriched
      WBPaper00050990:intestine_expressed
      WBPaper00051558:aging_regulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053289:DREAM-target
      WBPaper00053302:alovudine_24h_regulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053388:dauer_regulated_Cluster2
      WBPaper00053599:female_vs_male_downregulated
      WBPaper00053599:oocyte_vs_mitosis_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00055354:Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055565:AVK_enriched
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056034:pals-25(jy9)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056284:ints-5(RNAi)_upregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056619:CEPsh_enriched
      WBPaper00056826:hmc_biased
      WBPaper00056855:his-72(uge40)_upregulated
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058711:paraquat_downregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059567:olrn-1(ums9)_regulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059763:neuron_expressed
      WBPaper00059895:wounding_upregulated
      WBPaper00060100:SiNP_downregulated_mRNA
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060764:swsn-1(os22ts)_upregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:AIA
      WBPaper00061340:AIB
      WBPaper00061340:AIM
      WBPaper00061340:AIN
      WBPaper00061340:AIZ
      WBPaper00061340:ALA
      WBPaper00061340:ALM_BDU
      WBPaper00061340:AUA
      WBPaper00061340:AVA
      WBPaper00061340:AVB
      WBPaper00061340:AVD
      WBPaper00061340:AVE
      WBPaper00061340:AVG
      WBPaper00061340:AVJ
      WBPaper00061340:AVK
      WBPaper00061340:AVL
      WBPaper00061340:AWB
      WBPaper00061340:DA
      WBPaper00061340:DB
      WBPaper00061340:DD
      WBPaper00061340:DVC
      WBPaper00061340:I5
      WBPaper00061340:IL1
      WBPaper00061340:IL2
      WBPaper00061340:MC
      WBPaper00061340:Neuroblast_AIZ_FLP
      WBPaper00061340:Neuroblast_PVC_LUA
      WBPaper00061340:OLL
      WBPaper00061340:PVP
      WBPaper00061340:RIA
      WBPaper00061340:RIB
      WBPaper00061340:RIC
      WBPaper00061340:RID
      WBPaper00061340:RIH
      WBPaper00061340:RIM
      WBPaper00061340:RIS
      WBPaper00061340:RIV
      WBPaper00061340:RMD
      WBPaper00061340:RME
      WBPaper00061340:RMED
      WBPaper00061340:SIA
      WBPaper00061340:SIB
      WBPaper00061340:SMB
      WBPaper00061340:SMD
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:acy-2-F35C5.11
      WBPaper00061651:DVB_enriched
      WBPaper00061651:HSN_enriched
      WBPaper00061651:SIA_enriched
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00062056:lin-36(we31)_upregulated
      WBPaper00062103:neuron_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062440:crh-1(syb385)_downregulated
      WBPaper00064005:starvation_upregulated_N2_mRNA
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064107:lin-35(n745)_upregulated
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
      WBPaper00064871:hypoxia_downregulated_F1
      WBPaper00065029:cadmium_upregulated
      WBPaper00065158:AFD_enriched
      WBPaper00065835:Day11_vs_Day1_upregulated
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066110:Doxorubicin_upregulated_diploid
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00066232:hsf-1(RNAi)_upregulated_ash-2
      WBPaper00066232:hsf-1(RNAi)_upregulated_WT
      cgc4386_cluster_6_5
      WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Enriched_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00030839:Embryo_A_Class
      WBPaper00030839:Embryo_Pan_Neuronal
      WBPaper00030839:Larval_A_Class
      WBPaper00030839:Larval_Pan_Neuronal
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00031532:Larva_Pan_Neuronal_Enriched
      WBPaper00032165:differentially_expressed_with_age_medoid_2
      WBPaper00032948:StarveUp4
      WBPaper00034661:AgNPs_upregulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00036123:Cadmium_regulated
      WBPaper00036286:Pattern_H
      WBPaper00037695:WC_5-day
      WBPaper00040210:Chlorpyrifos_24C_regulated
      WBPaper00041174:environmental
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_and_environmental
      WBPaper00041207:CE_dauer_up
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041960:daf-16_fasting_upregulated
      WBPaper00041960:jun-1_fasting_upregulated
      WBPaper00041960:kgb-1_fasting_upregulated
      WBPaper00041960:N2_fasting_upregulated
      WBPaper00041960:N2_fasting_upregulated_anytime
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00048989:N2_allantoin_downregulated
      WBPaper00050538:Fasting_upregulated
      WBPaper00050538:Fasting_upregulated_cholesterol-dependent
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(53_min)
      [cgc5767]:expression_class_SE
      [cgc5767]:expression_class_SE_pi(53_min)
    Interaction: WBInteraction000144281
      WBInteraction000235359
      WBInteraction000522601
      WBInteraction000522602
      WBInteraction000555740
      WBInteraction000561376
      WBInteraction000566351
      WBInteraction000566630
  Map_info: Map: I Position: -2.60662 Error: 0.009286
    Positive: Positive_clone: C32E8 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4637
    Pseudo_map_position
  Reference (19)
  Remark: sequence connection from [Pilon M, Culotti J]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene