WormBase Tree Display for Gene: WBGene00004359

WBGene00004359 SMap: S_parent: Sequence: B0240
  Identity: Version: 1
    Name: CGC_name: rhr-2
      Sequence_name: B0240.1
      Molecular_name: B0240.1
        B0240.1.1
        CE05172
      Other_name: CELE_B0240.1 Accession_evidence: NDB BX284605
      Public_name: rhr-2
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:35 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: rhr
    Allele (34)
    Legacy_information: [Nettell J] rhr for Rh blood group antigen related. No mutants known. Predicted gene B0240.1
    Strain: WBStrain00030767
      WBStrain00031392
    RNASeq_FPKM (74)
    GO_annotation (12)
    Ortholog (42)
    Paralog: WBGene00000133 Caenorhabditis elegans From_analysis: Panther
      WBGene00000134 Caenorhabditis elegans From_analysis: Panther
      WBGene00000135 Caenorhabditis elegans From_analysis: Panther
      WBGene00000136 Caenorhabditis elegans From_analysis: Panther
      WBGene00004358 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: rhr-2 encodes a predicted transmembrane protein with similarity to human Rh blood group antigens proposed to function in inorganic ion transport and metabolism; the role of RHR-2 in C. elegans development or behavior remains unclear, as loss of RHR-2 function via RNA-mediated interference does not result in any abnormalities. Paper_evidence: WBPaper00005654
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable ammonium transmembrane transporter activity. Predicted to be involved in ammonium homeostasis and ammonium transmembrane transport. Located in apical plasma membrane. Expressed in several structures, including body wall musculature; head neurons; spermatheca; ventral nerve cord; and vulva. Human ortholog(s) of this gene implicated in Rh deficiency syndrome and overhydrated hereditary stomatocytosis. Is an ortholog of human RHAG (Rh associated glycoprotein); RHBG (Rh family B glycoprotein); and RHCG (Rh family C glycoprotein). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0050641 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10006)
      DOID:0111562 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10006)
      DOID:583 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10006)
  Molecular_info: Corresponding_CDS: B0240.1
    Corresponding_transcript: B0240.1.1
    Other_sequence (21)
    Associated_feature: WBsf234571
      WBsf234572
  Experimental_info: RNAi_result: WBRNAi00009624 Inferred_automatically: RNAi_primary
      WBRNAi00038784 Inferred_automatically: RNAi_primary
      WBRNAi00028024 Inferred_automatically: RNAi_primary
      WBRNAi00077595 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr3970
      Expr12741
      Expr1027846
      Expr1142991
      Expr2015340
      Expr2033574
    Drives_construct: WBCnstr00035540
    Construct_product: WBCnstr00022779
      WBCnstr00035540
    Microarray_results (18)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00038438:Harposporium_24hr_upregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_downregulated_TilingArray
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044736:oscillating_dev_expression
      WBPaper00045316:prg-1_upregulated_L4
      WBPaper00048923:Aging_regulated
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00050080:rbr-2(tm3141)_downregulated
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
      WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:hypodermis_enriched
      WBPaper00050990:hypodermis_expressed
      WBPaper00051404:alg-1(gk214)_upregulated
      WBPaper00051404:alg-2(ok304)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053388:dauer_regulated_Cluster4
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Psora_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin-Psora_downregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055626:pry-1(mu38)_upregulated
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00056161:male_enriched_siRNA
      WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058725:sftb-1(cer6)_downregulated
      WBPaper00059253:sucrose_stearic-acid_upregulated
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059728:5ug_cholesterol_upregulated
      WBPaper00059728:20ug_cholesterol_upregulated
      WBPaper00059824:rnp-6(dh1127)_regulated_OP50
      WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
      WBPaper00060100:SiNP_downregulated_mRNA
      WBPaper00060703:nas-38(ok3407)_upregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:hyp7_C_lineage
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:F40F8.4-C33G8.4
      WBPaper00061653:alh-4(hj221)_upregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064539:nhr-114(gk849)_upregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064769:him-17(me24)_upregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066232:ash-2(RNAi)_downregulated_WT
      cgc4386_cluster_6_5
      cgc4489_group_25
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00036286:Pattern_I
      WBPaper00038172:crh-1null_up_regulated
      WBPaper00042258:DA1877_upregulated_GravidAdult
      WBPaper00047070:N2_starvation_upregulated
      WBPaper00047070:N2_UV_upregulated
      WBPaper00047070:xpa-1_UV_upregulated
      WBPaper00048989:N2_rapamycin_upregulated
    Interaction: WBInteraction000328271
      WBInteraction000389534
      WBInteraction000390827
      WBInteraction000439732
  Map_info: Map: V Position: 3.30848 Error: 0.00541
    Positive: Positive_clone: B0240 Author_evidence: Nettell JJ
          Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4636
        4844
        4808
        5619
    Pseudo_map_position
  Reference: WBPaper00019491
    WBPaper00027209
    WBPaper00032929
    WBPaper00038491
    WBPaper00046515
    WBPaper00049246
    WBPaper00055090
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene